DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ube3a and Y92H12A.2

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_001293292.1	Gene:	Y92H12A.2 / 171719	WormBaseID:	WBGene00022358	Length:	724	Species:	Caenorhabditis elegans

Alignment Length:	398	Identity:	123/398 - (30%)
Similarity:	197/398 - (49%)	Gaps:	63/398 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   591 RMYSERYSSLHSILNNIGQVGQEDNPRPD-----LKLTVRRDQLINDALIGLEMVAMSNPKDLKK 650
            |.|..:...|.|.|           |:|:     ..:.|.||.|..|:   ...:......||:.
Worm   368 RDYKRKVEYLRSRL-----------PKPNSNSGKCDMVVHRDTLFEDS---YRHIMDKKDYDLRN 418

  Fly   651 QLVVEFVGEQGIDEGGVSKEFFQLIVEEIFNPAFGMFIQQEETNNMWFNATPF------ENGAQF 709
            :|.:||.||.|:|.|||::|:|.|:..:||||.:|:| :...|:|......|.      |:.:.|
Worm   419 KLWIEFFGETGLDYGGVTREWFFLLSHQIFNPYYGLF-EYSATDNYTLQINPHSEACNPEHLSYF 482

  Fly   710 TLIGIIIGLAIYNNVTLAVNFPMVVYRKLIGYCGTFADLSDWSPALYKSLKSMLDYQGQDMEEVF 774
            ..||.|||:|||:...|...|....|:.::|...|..|:.......|.||..:.|....|:
Worm   483 HFIGRIIGMAIYHGKLLDAFFIRPFYKMMLGKKITLFDMESVDNEYYNSLIYVKDNDPADL---- 543

  Fly   775 EQTFKISYSDVFGDVVQHELVPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGFEMVT 839
            |.||.:..| :||:....||:|||.:|.|.:.|||.::                       |.|.
Worm   544 ELTFSLDDS-IFGETQNIELIPNGANVPVTEDNKEEYI-----------------------EAVV 584

  Fly   840 DESPLKLLFRPEEIEMLVCGSREFDFVELENSTVYEGGYTEKSQYIQDFWSIVHAMPSEDKHKLL 904
            ..:.|: ||...|:|:|:||.::.|..:.:.:|:|:|||...||.:.:||..:.:..:|.:.::|
Worm   585 PSNLLR-LFDANELELLMCGLQKIDVKDWKANTIYKGGYGPSSQVVHNFWKCILSFDNEMRARVL 648

  Fly   905 EFTTGSARVPVGGLKCL-------RLLITRHGPDSDRLPTSHTCFNVLLLPEYSSREKLEERLMK 962
            :|.:|::|||:.|.:.|       :..|.|.| .:|.||.:|||||.|.||.|::.::|:.:|:.
Worm   649 QFVSGTSRVPMNGFRELYGSNGLQKFTIERWG-SADMLPRAHTCFNRLDLPPYTTFKELKSKLLT 712

  Fly   963 AINYSKGF 970
            ||..|:.|
Worm   713 AIENSEIF 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166
		HECTc	620..971	CDD:238033	116/364 (32%)
		HECTc	647..970	CDD:214523	110/335 (33%)
Y92H12A.2	NP_001293292.1	C2	20..147	CDD:301316
		WW	170..198	CDD:278809
		WW	272..301	CDD:278809
		WW	323..353	CDD:197736
		HECTc	393..721	CDD:238033	116/362 (32%)
		HECTc	415..720	CDD:214523	110/335 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810