DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ube3a and Itch

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_001230641.1	Gene:	Itch / 16396	MGIID:	1202301	Length:	864	Species:	Mus musculus

Alignment Length:	366	Identity:	117/366 - (31%)
Similarity:	200/366 - (54%)	Gaps:	26/366 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   620 LKLTVRRDQLINDALIGLEMVAMSNPKDLKKQLVVEFVGEQGIDEGGVSKEFFQLIVEEIFNPAF 684
            :|:||.|..|..|:   .:.:...:|:||:::|.|.|.||:|:|.|||::|:|.|:..|:.||.:
Mouse   509 IKITVTRKTLFEDS---FQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMY 570

  Fly   685 GMFIQQEETNN-MWFNATPFENG---AQFTLIGIIIGLAIYNNVTLAVNFPMVVYRKLIGYCGTF 745
            .:|....:.|. :..|...:.|.   ..|..||..|.:|:::...:...|.:..|::::......
Mouse   571 CLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFSLPFYKRILNKPVGL 635

  Fly   746 ADLSDWSPALYKSLKSMLDYQGQDMEEV-FEQTFKISYSDVFGDVVQHELVPNGQDVLVGQHNKE 809
            .||....|..|.||   :..:..::||. .|..|.:. .::.|::..|:|.|||.::||.:.|||
Mouse   636 KDLESIDPEFYNSL---IWVKENNIEECGLEMYFSVD-KEILGEIKSHDLKPNGGNILVTEENKE 696

  Fly   810 LFVNLYSDFLLNTNIEQQFNAFRKGFEMVTDESPLKLLFRPEEIEMLVCGSREFDFVELENSTVY 874
            .::.:.:::.|:..:|:|..||.:||..:..:..|: .|..:|:|:|:||.:|.|..:.:...:|
Mouse   697 EYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQ-YFDAKELEVLLCGMQEIDLNDWQRHAIY 760

  Fly   875 EGGYTEKSQYIQDFWSIVHAMPSEDKHKLLEFTTGSARVPVGGLKCLRLLITRHGPD-------- 931
            . .||..|:.|..||..|..:.:|.:.:||:|.||:.|:||||...   |:..:||.
Mouse   761 R-HYTRTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVGGFAD---LMGSNGPQKFCIEKVG 821

  Fly   932 -SDRLPTSHTCFNVLLLPEYSSREKLEERLMKAINYSKGFG 971
             .:.||.||||||.|.||.|.|.|:|:|:|:.||..::|||
Mouse   822 KENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFG 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166
		HECTc	620..971	CDD:238033	115/364 (32%)
		HECTc	647..970	CDD:214523	107/336 (32%)
Itch	NP_001230641.1	C2_E3_ubiquitin_ligase	17..140	CDD:175988
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..294
		WW	289..318	CDD:278809
		WW	321..350	CDD:278809
		Required for interaction with FYN. /evidence=ECO:0000250	356..432
		WW	401..430	CDD:278809
		WW	440..471	CDD:197736
		HECTc	509..862	CDD:238033	115/364 (32%)
		HECTc	533..861	CDD:214523	107/336 (32%)
		MAP kinase docking site	535..544		3/8 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810