DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ube3a and PLEKHA7

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	XP_024304124.1	Gene:	PLEKHA7 / 144100	HGNCID:	27049	Length:	1365	Species:	Homo sapiens

Alignment Length:	675	Identity:	132/675 - (19%)
Similarity:	217/675 - (32%)	Gaps:	217/675 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SSASGSAAGAVGGRA------TPE--------MKRSA---VRSLIKRYFHQLQ-SGCGNANCSNA 63
            ||.:||.|...|.|.      |.|        |.::|   .||.:||...::: .....|| ...
Human   245 SSTAGSQAEQSGMRTYYFSADTQEDMNAWVRAMNQAAQVLSRSSLKRDMEKVERQAVPQAN-HTE 308

  Fly    64 NCASSGKVAPMTPNEVAARA---LQLFSQDAQLCEAFTSEAN---------------SPQDVDML 110
            :|...|:|.|....:...|.   :..|.:..|..|.:.|:.:               ||.:.|.|
Human   309 SCHECGRVGPGHTRDCPHRGHDDIVNFERQEQEGEQYRSQRDPLEGKRDRSKARSPYSPAEEDAL 373

  Fly   111 ------SPNDSSSSSSGSSTSTITSAS-----------------TTTTTSRQSQ----------- 141
                  .|....:....:..:.:..||                 ..|...:.||
Human   374 FMDLPTGPRGQQAQPQRAEKNGMLPASYGPGEQNGTGGYQRAFPPRTNPEKHSQRKSNLAQVEHW 438

  Fly   142 ---------STPAAVVVP-------VSSPYLTQSVPQLDIAGAEHSSGDSEPCTPTLAPVHSLDA 190
                     |.|....:|       :|.|...|::|:    ...|.||.|.|      |..:|.:
Human   439 ARAQKGDSRSLPLDQTLPRQGPGQSLSFPENYQTLPK----STRHPSGGSSP------PPRNLPS 493

  Fly   191 NSLIALYEQCRAA----DSYDRICHAIGVVFSSVDRLGKSFIRSAEPAASSSLQELLANSPGALN 251
            :   ..|.|.||:    .|.:|..|..|.|:...:...:...|...|.|...|     .||...:
Human   494 D---YKYAQDRASHLKMSSEERRAHRDGTVWQLYEWQQRQQFRHGSPTAPICL-----GSPEFTD 550

  Fly   252 KEQLRTL----------------------------------EGEHDKDEDSTQQV-----DEQSE 277
            :.:.|::                                  |....|..|..:.|     |....
Human   551 QGRSRSMLEVPRSISVPPSPSDIPPPGPPRVFPPRRPHTPAERVTVKPPDQRRSVDISLGDSPRR 615

  Fly   278 SAANATATAESVESEAEPE-------EEDDDVCSSQSSDTLVDLPGLRRVQRLLFGCQIRAITE- 334
            :..:|...:..|:..:.|.       .....:......:..:.|..|||.|..|...:..||::
Human   616 ARGHAVKNSSHVDRRSMPSMGYMTHTVSAPSLHGKSLEELSLLLTRLRRHQAKLASVRNFAISQL 680

  Fly   335 ---KLTSSVIQLSDWVIYMRTDWERVIHCLVICFDLATNTNNSVVDMDYLDRVLPK--------- 387
               :||....|..|..:.::.|.|.:        ||....|..::::.|  :||.|
Human   681 LQHQLTFPTCQADDTYLQLKKDLEYL--------DLKIKNNEPLINVLY--KVLKKSARGCRPRR 735

  Fly   388 ------LCQAASAMPVPAQARLARIWAAHCSDQLHSLIAACQQQITLQVLLDE-ESMREN-ESII 444
                  |.:..|..||    ::|.      ||....|...|:|...||.|.|: .:::|| :.:.
Human   736 SMTGRDLLKDRSLKPV----KIAE------SDTDVKLSIFCEQDRVLQDLEDKIRALKENKDQLE 790

  Fly   445 SVTKVL---------------KIVFYANILASELERPSCRVPLEDRTEAATA-SGSAAVEDDL-F 492
            ||.:||               ||.:...:|..:|......:..|. ||...| :....:|:|: .
Human   791 SVLEVLHRQMEQYRDQPQHLEKIAYQQKLLQEDLVHIRAELSRES-TEMENAWNEYLKLENDVEQ 854

  Fly   493 VYNSLLEPHMPKF---AEDQFEKEL 514
            :..:|.|.|...|   .:.|.:|:|
Human   855 LKQTLQEQHRRAFFFQEKSQIQKDL 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166	13/57 (23%)
		HECTc	620..971	CDD:238033
		HECTc	647..970	CDD:214523
PLEKHA7	XP_024304124.1	WW	11..40	CDD:306827
		WW	56..85	CDD:306827
		PH_PEPP1_2_3	159..281	CDD:270068	10/35 (29%)
		NESP55	<299..460	CDD:115071	24/161 (15%)
		DUF1640	779..905	CDD:311647	23/102 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900