DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ube3a and HECTD2

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_001271203.2	Gene:	HECTD2 / 143279	HGNCID:	26736	Length:	780	Species:	Homo sapiens

Alignment Length:	941	Identity:	254/941 - (26%)
Similarity:	419/941 - (44%)	Gaps:	210/941 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 APMTPNEVAARALQ----LFSQDAQLCEAFTSEANSPQDVDMLSPNDSSSSSSGSSTSTITSAST 132
            :|.||..|||.|.:    ..|:..:|....::.|.:...:      |..:....|:.|:..||.:
Human     9 SPATPLVVAAPAPEERKGKESEREKLPPIVSAGAGATAGL------DRGAKGQISTFSSFISAVS 67

  Fly   133 TTTTSRQSQSTPAAVVVP----VSSPYLTQSVPQ--LDIAGAEHSSGD---SEPCTPTL----AP 184
            ....:.:::|:||.:|.|    |..|      |.  ||:...:.:|.|   ||...|.|    .|
Human    68 PKKEAAENRSSPAHLVFPNIKNVREP------PPICLDVRQKQRTSMDASSSEMKAPVLPEPILP 126

  Fly   185 VHSLDANSLIALYEQCRAADSYDRICHAIGVVFSSVDRLGKSFIRSAEPAASSSLQELLANSPGA 249
            :............|:.:::..:..:.......|.|...|..:|
Human   127 IQPKTVKDFQEDVEKVKSSGDWKAVHDFYLTTFDSFPELNAAF---------------------- 169

  Fly   250 LNKEQLRTLEGEHDKDEDSTQQVDEQSESAANATATAESVESEAEPEEEDDDVCSSQSSDTLVDL 314
                           .:|:|...:...:|..||...                   :...|||::.
Human   170 ---------------KKDATASFNTIEDSGINAKFV-------------------NAVYDTLLNT 200

  Fly   315 PGLRRVQRLLFGCQIRAITEKLTSSVIQLSDWVIYMRTDWERVIHCLVICFDLATNTNNSVVDMD 379
            |  :.||:.:    ::.|...|      |.:|. ..||..:...:.:::......||:..|: ..
Human   201 P--QDVQKTV----LKGIINSL------LREWK-GPRTKDDLRAYFILLQNPQFNNTSTYVI-YA 251

  Fly   380 YLDRVLPKLCQAASAMPVPAQARLARIWAAHCSDQLHSLIAACQQQITLQVLLDEESMR----EN 440
            :|.|.:..|.:|.....|            |...:.:|.::..:.:..::.||...|:|    :.
Human   252 HLLRQIATLVEADHHFLV------------HWFKKQYSRLSQKRFKQLVERLLQFISLRLFPAKP 304

  Fly   441 ESIISVTKVLKIVFYANILASELERPSCRVPLEDRTEAATASGSAAVEDDLFVYNSLLEPHMPKF 505
            |....:||.                 |..:|           .:|.|...|...|:|:.|
Human   305 EEFPPITKC-----------------SWWIP-----------SAAKVLALLNTANNLVHP----- 336

  Fly   506 AEDQFEKELQVSAIDCRKPLIPLEEFYNEALSENIQMHHDYLSYKTLAMESEIGSGHANYFSFML 570
                              ||||..:|||..| ::|.:..:|.:::..        |:::.|||..
Human   337 ------------------PLIPYTDFYNSTL-DHIDLMEEYHTWQNF--------GNSHRFSFCQ 374

  Fly   571 YAFILTPSTKVDALYYDSRMRMYSERYSSLHSILNNIGQVGQEDNPRPD-----LKLTVRRDQLI 630
            |.|:::.:.|...:..||..:|.:....||      :.:|.:..  |||     |.:.|||..|:
Human   375 YPFVISVAAKKIIIQRDSEQQMINIARQSL------VDKVSRRQ--RPDMNILFLNMKVRRTHLV 431

  Fly   631 NDALIGLEMVAMSNPKDLKKQLVVEFVGEQGIDEGGVSKEFFQLIVEEIFNPAFGMFIQQEETNN 695
            :|:|..|    .....||||:|.|.||||.|:|.||::||:|.|::.:||:|.:|||...::::.
Human   432 SDSLDEL----TRKRADLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPDYGMFTYHKDSHC 492

  Fly   696 MWFNATPFENGAQFTLIGIIIGLAIYNNVTLAVNFPMVVYRKL-------------IGYCG-TFA 746
            .||::...:|.::|.|:||::|||:||::||.:.||...|:||             :|.|. |..
Human   493 HWFSSFKCDNYSEFRLVGILMGLAVYNSITLDIRFPPCCYKKLLSPPIIPSDQNIPVGICNVTVD 557

  Fly   747 DLSDWSPALYKSLKSMLDYQGQDMEEVFEQTFKISYSDVFGDVVQHELVPNGQDVLVGQHNKELF 811
            ||....|.|...|..:|.::| ::||.|..||:: :.:.||.:..:.|.|.|..:.|...|::.:
Human   558 DLCQIMPELAHGLSELLSHEG-NVEEDFYSTFQV-FQEEFGIIKSYNLKPGGDKISVTNQNRKEY 620

  Fly   812 VNLYSDFLLNTNIEQQFNAFRKGFEMVTDESPLKLLFRPEEIEMLVCGSREFDFVELENSTVYEG 876
            |.||:|||||.:|.:||.||..||..|...:.|.|| ||||:|:|||||.:.|...|:.||.|:
Human   621 VQLYTDFLLNKSIYKQFAAFYYGFHSVCASNALMLL-RPEEVEILVCGSPDLDMHALQRSTQYD- 683

  Fly   877 GYTEKSQYIQDFWSIVHAMPSEDKHKLLEFTTGSARVPVGGLKCLRLLITRHGPDSDRLPTSHTC 941
            ||.:....|:.||.:|...|.:.:.|||.|||||.||||||:..|...|:::...::.||.:|||
Human   684 GYAKTDLTIKYFWDVVLGFPLDLQKKLLHFTTGSDRVPVGGMADLNFKISKNETSTNCLPVAHTC 748

  Fly   942 FNVLLLPEYSSREKLEERLMKAINYSKGFGM 972
            ||.|.||.|.|::.|:::|:..|:.|:|||:
Human   749 FNQLCLPPYKSKKDLKQKLIIGISNSEGFGL 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166	8/25 (32%)
		HECTc	620..971	CDD:238033	147/364 (40%)
		HECTc	647..970	CDD:214523	138/336 (41%)
HECTD2	NP_001271203.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46		10/36 (28%)
HECTD2	NP_001271203.2	HECTc	421..778	CDD:238033	147/364 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276447at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101192
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.720