DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ube3a and Ube3b

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_473434.2	Gene:	Ube3b / 117146	MGIID:	1891295	Length:	1070	Species:	Mus musculus

Alignment Length:	821	Identity:	198/821 - (24%)
Similarity:	331/821 - (40%)	Gaps:	203/821 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   301 DVCSS-QSSDTLVDLPGLRRVQRLLFGCQIRAITEKLTSSVIQLSDWVIYMR----------TDW 354
            |.|.| :...||..:..|..:..|    .:|.:.|::...|..|:..:.|.:          |.|
Mouse   299 DACESLEGCHTLCLMGNLLHLGSL----SLRLLEEEMDGFVSALTQMLCYCQKYVAQKKSNLTHW 359

  Fly   355 ERVIHCLVICFDLATNTNNSVVDMDYLDRVLPKLCQAASAMPVPAQARLARIWAAHCSDQL---- 415
            ..|:.......|...|      |..||   :.|..|...|:|      |.||.   .||.|
Mouse   360 HPVLGWFSQPVDYGLN------DSMYL---ITKQLQFLWAVP------LIRIL---FSDILSRKL 406

  Fly   416 --HSLIAACQ-QQITLQVLLDEESM--RENESIISVTKVLKIVFYANILASELERPSCRVPLEDR 475
              |:..|..| |..:.|.:|..:|:  |..:...||..:|:.|....:.::|: |..|.:.:..:
Mouse   407 LEHAEPAPVQPQPSSPQTVLPVKSLLKRAFQKSASVRNILRPVGGRRVDSAEV-RKVCNICVLYQ 470

  Fly   476 TEAAT--------ASGSAAVED---DLFVYNSLLEPH--MPKFAE----DQFEKELQVSAI---- 519
            |...|        .:|...::|   .|:.:...|.||  :..|.|    |..|.:..::.:
Mouse   471 TSLTTLTQIRLQILTGLTYLDDLLPKLWAFICELGPHGGLKLFLECLNNDTGESKQLLAMLMLFC 535

  Fly   520 DCRKPLIPLEEFYNEALSENIQMHHDYLSYKTLAMESEIG-SGHANYFSFMLYAFILTPSTKVDA 583
            ||.:.||        .:.::|:::.:.:|:|   :|..:. |...|.|.|.:....:..:.|.:.
Mouse   536 DCSRHLI--------TILDDIEVYEEQISFK---LEELVTISSFLNSFVFKMIWDGIVENAKGET 589

  Fly   584 LYYDSRMRMYSERYSSLHSILNNI------GQVGQEDN-PRPDLK-------------------- 621
            |          |.:.|:|..|..:      .:...||: .|.|||
Mouse   590 L----------ELFQSVHGWLMVLYERDCRRRFAPEDHWLRRDLKPGVLFQELDKDRRRAQLVLQ 644

  Fly   622 ----------------------------------------LTVRRDQLINDALIGLEMVAMSNPK 646
                                                    :|:||.:::.|   |.|.:...:..
Mouse   645 HIPHVVPHKNRVLLFRNMVIKEKEKLGLVETSSASPHVTHITIRRSRMLED---GYEQLRQLSQH 706

  Fly   647 DLKKQLVVEFVG-----EQGIDEGGVSKEFFQLIVEEIFNPAFGMFIQQEETNNMWFNATPF--E 704
            .:|..:.|:||.     |.|||:.||.|||.:.|::.:|:||..:|........::.:.|.:  |
Mouse   707 AMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPTSYIHE 771

  Fly   705 NGAQ-FTLIGIIIGLAIYNNVTLAVNFPMVVYRKLIG-YCGTFADLSDWSPAL----YKSLKSML 763
            |..| |..:|.::|.|:|..:.:.|.|......:::| :...|....|..|:|    ||:|.|:.
Mouse   772 NYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQMLGHHHSVFYSSVDELPSLDSEFYKNLTSIK 836

  Fly   764 DYQGQDMEEVFEQTFKISY-SDVFGDVVQHELVPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQ 827
            .|.|    ::.:....:|| .||.|.:|.|||||.|:.:.|...||..:::|.:.|.::|.|:.|
Mouse   837 RYDG----DIADLGLTLSYDEDVMGQLVCHELVPGGKTIPVTDENKISYIHLMAHFRMHTQIKNQ 897

  Fly   828 FNAFRKGFEMVTDESPLKLLFRPEEIEMLVCG-SREFDFVELENSTVYEGGYTEKSQYIQDFWSI 891
            ..|...||..:.....:::...| |::.|:.| :.|.|..:|:..|||.||:....:.|...|.|
Mouse   898 TAALISGFRSIIKPEWIRMFSTP-ELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDI 961

  Fly   892 VHA-MPSEDKHKLLEFTTGSARVPVGG---------LKC----------------LRLLIT-RHG 929
            :.: ...|::...|:|.|..:|.|:.|         ::|                ||...| |..
Mouse   962 LASDFTPEERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKR 1026

  Fly   930 PDSDRLPTSHTCFNVLLLPEYSSREKLEERLMKAINYSKGF 970
            ....|||||.||||:|.||.||.:..|.|:|..||:.:.||
Mouse  1027 EPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGF 1067

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166
		HECTc	620..971	CDD:238033	119/453 (26%)
		HECTc	647..970	CDD:214523	109/364 (30%)
Ube3b	NP_473434.2	HECTc	684..1068	CDD:238033	117/392 (30%)
Ube3b	NP_473434.2	HECTc	709..1067	CDD:214523	109/362 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900