DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ube3a and Wwp1

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_796301.2	Gene:	Wwp1 / 107568	MGIID:	1861728	Length:	918	Species:	Mus musculus

Alignment Length:	996	Identity:	235/996 - (23%)
Similarity:	374/996 - (37%)	Gaps:	286/996 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 SGSAAGAVGGRATPEMKRSAVRSLIKRYFHQLQSGCGNANCSNA----NCAS---SGKVAPMTPN 77
            :|.|....|..||....|..|...|         |..|...:|.    :|.|   :|:..|.:|:
Mouse   163 NGDALHENGDPATRTTPRLPVEGTI---------GIDNHVSTNTVVPNSCCSHVVNGENTPSSPS 218

  Fly    78 EVAARALQLFSQDAQLCEAFTSEANSPQDVDMLSPNDSSSSSSGSSTST----ITSASTTTTTSR 138
            :||||     .::|...:..||...|.      :.|..|||....:|||    :.|..||:|::.
Mouse   219 QVAAR-----PKNAPAPKPVTSAPTSD------TVNGESSSVLADNTSTMGTLLPSEDTTSTSNC 272

  Fly   139 QSQSTPAAVVVPVSSPYLTQSVPQLDIAGAEHSSGDSEPCTPTLAPVHSLDANSLIALYEQCRAA 203
            .|.:|...   ||..|      |    |.:|||.     |.|:.:.....:|.|||......|..
Mouse   273 TSTTTQEP---PVQEP------P----ASSEHSE-----CIPSASAEVGPEARSLIDPDSDSRNN 319

  Fly   204 DSYDRICHAIGVVFSSVDRLGKSFIRSAEPAASSSLQELLANSPGALNKEQLRTLEGEHDKDEDS 268
            ..:|::....|.|               ||....|         |..|.|.|.:...:.......
Mouse   320 SVFDKVRQPEGCV---------------EPLRPQS---------GNTNTEALPSGWEQRKDPHGR 360

  Fly   269 TQQVDEQSESAANATATAESVESEAEPEEEDDDVCSSQSSDTLVDLPGLRRVQRLLFGCQIRAIT 333
            |..||..:.     |.|.|                               |.|.|..|
Mouse   361 TYYVDHNTR-----TTTWE-------------------------------RPQPLPPG------- 382

  Fly   334 EKLTSSVIQLSDWVIYMRTDWERVIHCLVICFDLATNTNNSVVDMDYLDRVLPKLCQAASAMPVP 398
                                |||.:           :....|..:|:..|.      .....|..
Mouse   383 --------------------WERRV-----------DDRGRVYYVDHNTRT------TTWQRPTM 410

  Fly   399 AQARLARIWAAHCSDQLHSLIAACQQQITLQVLLDEESMRENESIISVTKVLKIVFYANILASEL 463
            ...|....|    ..|.:.|..|.||              .|:         :.::.|::||:|.
Mouse   411 ESVRNFEQW----QSQRNQLQGAMQQ--------------FNQ---------RYLYSASMLAAEN 448

  Fly   464 ERPSCRVP--LEDRTEAATASGSAAVEDDLFVYNSLLEPHMPKFAEDQFEKELQVSAIDCRKPLI 526
            : |...:|  .|.|.::.         |.::..|     |..|  ..|:|        |.|...:
Mouse   449 D-PYGPLPPGWEKRVDST---------DRVYFVN-----HNTK--TTQWE--------DPRTQGL 488

  Fly   527 PLEEFYNEALSENIQMHHDYLSYKTLAMESEIGSGHANYFSFMLYAFILTPSTKVDALYYDSRMR 591
            |.|    |.|.|..::.:.....:              ||              ||   :::|..
Mouse   489 PNE----EPLPEGWEIRYTREGVR--------------YF--------------VD---HNTRTT 518

  Fly   592 MYSERYSSLHSILNNIGQVGQE---------------DNPRPD-LKLTVRRDQLINDALIGLEMV 640
            .:.:..:...|:.....|:..|               .|..|. :|:.|.|..|..|:   .:.:
Mouse   519 TFKDPRNGKSSVTKGGPQIAYERSFRWKLAHFRYLCQSNALPSHVKINVSRQTLFEDS---FQQI 580

  Fly   641 AMSNPKDLKKQLVVEFVGEQGIDEGGVSKEFFQLIVEEIFNPAFGMFIQQEETNNMWFNATPF-- 703
            ....|.||:::|.|.|.||:|:|.||:::|:|.|:..|:.||.:.:| :....||......|.
Mouse   581 MALKPYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLF-EYAGKNNYCLQINPAST 644

  Fly   704 ---ENGAQFTLIGIIIGLAIYNNVTLAVNFPMVVYRKLIGYCGTFADLSDWSPALYKSLKSMLDY 765
               ::.:.|..||..|.:|:::...:...|.:..|::::....|..||.......|.||..:.|
Mouse   645 INPDHLSYFCFIGRFIAMALFHGKFIDTGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRD- 708

  Fly   766 QGQDMEEV-FEQTFKISYSDVFGDVVQHELVPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFN 829
              .::||. .|..|.:. .::.|.|..|:|...|.::||.:.||:.::.|.:::..:..:::|..
Mouse   709 --NNIEECGLEMYFSVD-MEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTK 770

  Fly   830 AFRKGFEMVTDESPLKLL--FRPEEIEMLVCGSREFDFVELENSTVYEGGYTEKSQYIQDFWSIV 892
            ||..||..|.   ||:.|  |..:|:|:::||.:|.|..:.:.:|||. .||..|:.|..||..|
Mouse   771 AFLDGFNEVV---PLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYR-HYTRNSKQIIWFWQFV 831

  Fly   893 HAMPSEDKHKLLEFTTGSARVPVGGLKCL-------RLLITRHGPDSDRLPTSHTCFNVLLLPEY 950
            ....:|.:.:||:|.||:.|:|:||...|       :..|.:.|.|: .||.||||||.|.||.|
Mouse   832 KETDNEVRMRLLQFVTGTCRLPLGGFAELMGSNGPQKFCIEKVGKDT-WLPRSHTCFNRLDLPPY 895

  Fly   951 SSREKLEERLMKAINYSKGFG 971
            .|.|:|:|:|:.||..::|||
Mouse   896 KSYEQLKEKLLFAIEETEGFG 916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166	15/60 (25%)
		HECTc	620..971	CDD:238033	115/365 (32%)
		HECTc	647..970	CDD:214523	108/337 (32%)
Wwp1	NP_796301.2	C2_E3_ubiquitin_ligase	17..140	CDD:175988
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	150..182		6/18 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	209..360		49/203 (24%)
		Interaction with ERBB4. /evidence=ECO:0000269\|PubMed:19561640	345..525		53/346 (15%)
		WW	347..376	CDD:278809	7/64 (11%)
		WW	379..408	CDD:278809	8/72 (11%)
		WW	454..483	CDD:278809	9/52 (17%)
		WW	495..524	CDD:238122	6/59 (10%)
		HECTc	564..916	CDD:238033	115/364 (32%)
		HECTc	587..915	CDD:214523	108/337 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810