DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ube3a and YAP1

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	XP_005271435.1	Gene:	YAP1 / 10413	HGNCID:	16262	Length:	510	Species:	Homo sapiens

Alignment Length:	527	Identity:	104/527 - (19%)
Similarity:	172/527 - (32%)	Gaps:	187/527 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 GKVAPMTPNEVAARALQLFSQ---------------DAQLCEAFTS-----EANSPQDVDM---- 109
            |:..|..|.:.|..|.|...|               :..|...|.:     .||.||.|.|
Human    26 GQGPPSGPGQPAPAATQAAPQAPPAGHQIVHVRGDSETDLEALFNAVMNPKTANVPQTVPMRLRK 90

  Fly   110 -----LSPNDSSSSSSGSSTSTITSASTTTTTSRQSQS--------------TPAAVVV-PVSSP 154
                 ..|.:..|.|..:||...|:.:.|....|...|              ||..||. |.::|
Human    91 LPDSFFKPPEPKSHSRQASTDAGTAGALTPQHVRAHSSPASLQLGAVSPGTLTPTGVVSGPAATP 155

  Fly   155 ---YLTQS---VPQLDI---AG---AEHSSGD-------------SEP----------CTPTLAP 184
               :|.||   :|. |:   ||   |:.|||.             .:|          ..||..|
Human   156 TAQHLRQSSFEIPD-DVPLPAGWEMAKTSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPP 219

  Fly   185 VHSLDANS----LIALYEQCRAADSYDRICHAIGVVFSSVD-----RLGKSF---------IRSA 231
            |.....||    |...:||....|......:......|.:|     |.||:.         ::..
Human   220 VQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRLDPRFGKAMNQRISQSAPVKQP 284

  Fly   232 EPAASSSLQELLANSPGALNKEQLRTLEGEHDKD------EDSTQQVDEQ-----SESAANATAT 285
            .|.|..|.|..:.....:..::|:|..:.:.:|:      ::..:||..|     :.|.||:...
Human   285 PPLAPQSPQGGVMGGSNSNQQQQMRLQQLQMEKERLRLKQQELLRQVRPQAMRNINPSTANSPKC 349

  Fly   286 AE-SVESEAEPEEEDDDVCSSQSSDTLVDLPGLRRVQRLLFGCQIRAIT---------------- 333
            .| ::.|:....|:|....:..||      ||:.:        ::|.:|
Human   350 QELALRSQLPTLEQDGGTQNPVSS------PGMSQ--------ELRTMTTNSSDPFLNSGTYHSR 400

  Fly   334 EKLTSSVIQLSDWVIYMRTDWERVIHCLVICFDLATNTNNSVVDMDYLDRVLPKLCQAASAMPVP 398
            ::.|.|.:.:|.:.:....|                :..|||.:||..|.:        :...:|
Human   401 DESTDSGLSMSSYSVPRTPD----------------DFLNSVDEMDTGDTI--------NQSTLP 441

  Fly   399 AQARLARIWAAHCSDQLHSL----------------IAACQQQITLQVLLDEESMRENESIISVT 447
            :|..       ...|.|.::                |...:...:||..|..:.:.:.||:::.|
Human   442 SQQN-------RFPDYLEAIPGTNVDLGTLEGDGMNIEGEELMPSLQEALSSDILNDMESVLAAT 499

  Fly   448 KVLKIVF 454
            |:.|..|
Human   500 KLDKESF 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166	7/39 (18%)
		HECTc	620..971	CDD:238033
		HECTc	647..970	CDD:214523
YAP1	XP_005271435.1	WW	174..203	CDD:238122	6/28 (21%)
YAP1	XP_005271435.1	WW	232..261	CDD:366073	5/28 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900