DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ube3a and Ube3c

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_598668.1	Gene:	Ube3c / 100763	MGIID:	2140998	Length:	1083	Species:	Mus musculus

Alignment Length:	879	Identity:	206/879 - (23%)
Similarity:	349/879 - (39%)	Gaps:	196/879 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 NSLIALYEQCRAADSYDRICHAIGVVFSSVDRLGKSFIRSAEPAASSSLQELLANSPGALNKE-- 253
            |:|:.|..|.      .:.|..:..:|..|..:|::::                   |||:::
Mouse   299 NALLLLESQS------SKRCSGVPWLFYFVLTVGENYL-------------------GALSEDGL 338

  Fly   254 --QLRTLEGEHDKDEDSTQQVDEQSESAANATATAESVESEAEPEEEDDDVCSSQSSDTLVDLPG 316
              .||.|           |....|..::...|...:|.....:..||.|...|.:  |..|..|.
Mouse   339 LVYLRVL-----------QTFLSQLPASPTGTGCPDSTSDSEDDNEETDQPNSPE--DGRVSAPY 390

  Fly   317 LRRVQRLLFGCQIRAITEKLTSSVIQL------SDWVIYMRTDWERVIHCLVI-----------C 364
            :..      .|..:..|::.|::::.|      |:.|.   |....:.|.|::           .
Mouse   391 ITE------ECLRKLDTKQQTNTLLNLVWRDSASEEVF---TRMASICHTLMVQHRMMVPKVRLL 446

  Fly   365 FDLATNTN---------NSVVDMDYLDRVLP--KLCQAASAMPVPAQARLARIWAAHCSDQLHSL 418
            :.||.|..         :|:........::|  :|....|.|.....:|:..::....|...|||
Mouse   447 YSLAFNARFLRHLWFLISSMTTQMITGSMVPLLQLISRGSPMSFEDSSRIIPLFYLFSSLFSHSL 511

  Fly   419 IAACQQQITLQVLLDEESMRENESI---ISV-----TKVLKIVFYANILASELERPSC------- 468
            |                |:.:||..   |.|     :.::.......||.|...|.:|
Mouse   512 I----------------SIHDNEFFGDPIEVVGQRQSSMMPFTLEELILLSRCLRDACLGIIKLA 560

  Fly   469 --RVPLEDRTEAATASGSAAVEDDLFVYNSLLEPHMPKFAEDQFEKELQVSAI-----------D 520
              ....|.|.|..||..|..|     ..||    .|.:..:.:.::.:|:..:           |
Mouse   561 YPETKPEVREEYVTAFQSIGV-----TTNS----EMQQCIQMEQKRWVQLFKVITNLVKMLKSRD 616

  Fly   521 CRKPLIPLEEFYNEALSENIQMHHDYLSYKTLAMESEIGSGHANYFSFMLYAFILTPSTKVD--- 582
            .|:...|    .|..|||...:..|.::...:.     .|.|...|..|.....|..:.:|.
Mouse   617 TRRNFCP----PNHWLSEQEDIKADKVTQLYVP-----ASRHVWRFRRMGRIGPLQSTLEVGLES 672

  Fly   583 ---ALYYDSRMRM---------YSERYSSLHSILNNIGQVGQEDNPRPD-LKLTVRRDQLINDAL 634
               ::..:.::.:         :.||......::....|..|.|.|..| :.:|:||:.:..||
Mouse   673 LPLSVSEERQLAILTELPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGINVTIRRNYIYEDA- 736

  Fly   635 IGLEMVAMSNPKDLKKQLVVEFVG-----EQGIDEGGVSKEFFQLIVEEIFNPAFGMFIQQEETN 694
              .:.::..|..||||::.|..:.     |.|||.||:.:||...:::..|||..|.|   :.||
Mouse   737 --YDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFF---KTTN 796

  Fly   695 NMWFNATPFENGAQ----------FTLIGIIIGLAIYNNVTLAVNFPMVVYRKLIGYCGTFAD-- 747
            .......|   .||          :..:|.::|.|:|.|:.:.:.|......||:   ||.||
Mouse   797 EGLLYPNP---AAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLL---GTSADVD 855

  Fly   748 ---LSDWSPALYKSLKSMLDYQGQDMEEVFEQTFKISYSDVFGDVVQHELVPNGQDVLVGQHNKE 809
               |:...|.:|::|..:..|: :|:||: ...|.:..:|: |:....||...|:|:.|...|:.
Mouse   856 IHHLASLDPEVYRNLLFLKSYE-EDVEEL-GLNFTVVNNDL-GEAQVVELKFGGKDIPVTGANRI 917

  Fly   810 LFVNLYSDFLLNTNIEQQFNAFRKGFEMVTDESPLKLLFRPEEIEMLVCGSR-EFDFVELENSTV 873
            .:::|.:|:.||..|.....|||:|...|.....|: :|..:||::|:.|:: .....:|::.|.
Mouse   918 AYIHLVADYRLNKQIRPHCLAFRQGLANVVSLEWLR-MFDQQEIQVLISGAQVPVSLEDLKSFTN 981

  Fly   874 YEGGYTEKSQYIQDFWSIVHAMPSEDKHKLLEFTTGSARVPVGGLKCL--RLLITRHGPDSDRLP 936
            |.|||:.....|:.||.:|.....|:|.|||:|.|..:|.|:.|.|.|  ...|...|.|.:|||
Mouse   982 YSGGYSADHPVIKIFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGSDLERLP 1046

  Fly   937 TSHTCFNVLLLPEYSSREKLEERLMKAINYSKGF 970
            |:.||.|:|.|||:.....|..:|:.||..:.||
Mouse  1047 TASTCMNLLKLPEFYDEALLRSKLLYAIECAAGF 1080

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166
		HECTc	620..971	CDD:238033	116/374 (31%)
		HECTc	647..970	CDD:214523	108/345 (31%)
Ube3c	NP_598668.1	Cis-determinant of acceptor ubiquitin-binding. /evidence=ECO:0000250	1..60
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..386		7/33 (21%)
		HECTc	723..1081	CDD:238033	116/374 (31%)
		HECTc	747..1080	CDD:214523	108/345 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810