Protein Alignment Ube3a and HUWE1

DIOPT Version :9

• Sequence 1: NP_648452.1
• Gene: Ube3a / 39266
• FlyBaseID: FBgn0061469
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: XP_016884680.1
• Gene: HUWE1 / 10075
• HGNCID: 30892
• Length: 4501
• Species: Homo sapiens
• Alignment Length: 1170
• Identity: 266/1170 - (22%)
• Similarity: 440/1170 - (37%)
• Gaps: 304/1170 - (25%)

  Fly     4 GGGGEDDQHLPGVSSASGSAAGAVGGRATPEMKRSAVRSLIK------RYFHQ---LQSGC---- 55
            ||....::|      |||.:...:..:|.|.:.|..:.:||:      .:|.|   .::.|
Human  3434 GGRKHTEKH------ASGGSTVHIHPQAAPVVCRHVLDTLIQLAKVFPSHFTQQRTKETNCESDR 3492

  Fly    56 --GNANCS-----------------------NANCASSGK----------------------VAP 73
              ||..||                       |.|.:..||                      .:|
Human  3493 ERGNKACSPCSSQSSSSGICTDFWDLLVKLDNMNVSRKGKNSVKSVPVSAGGEGETSPYSLEASP 3557

  Fly    74 MTP----------------NEVAARALQLFSQDAQLCEAFTSEANSPQDVDMLSPNDSSSSSSGS 122
            :..                .|...|.|.|.|  ..|.|...|||            .::|.|..|
Human  3558 LGQLMNMLSHPVIRRSSLLTEKLLRLLSLIS--IALPENKVSEA------------QANSGSGAS 3608

  Fly   123 STSTITS-ASTTTTTSRQSQSTPAAVVVPVSSPYLTQSVPQLDIAGAEHS---SGDSEPCTPTLA 183
            ||:|.|| .||||||:..:..||.....||:      |.|.|..|.|..:   :..:...|||.|
Human  3609 STTTATSTTSTTTTTAASTTPTPPTAPTPVT------SAPALVAATAISTIVVAASTTVTTPTTA 3667

  Fly   184 ---------------PVHSLDANSLIALYEQCRAADSYDRICHAIGVVFS-SVDRLGKSFIRSAE 232
                           |....|..|....::...:..:.:::..::.|:.| |....|      .|
Human  3668 TTTVSISPTTKGSKSPAKVSDGGSSSTDFKMVSSGLTENQLQLSVEVLTSHSCSEEG------LE 3726

  Fly   233 PAASSSLQ-------------ELLANSPGALNK---EQLRTLEGEHDKDEDSTQQVDEQSESAAN 281
            .||:..||             :||.|....|..   :|:.||..|. ::.:..||
Human  3727 DAANVLLQLSRGDSGTRDTVLKLLLNGARHLGYTLCKQIGTLLAEL-REYNLEQQ---------- 3780

  Fly   282 ATATAESVESEAEPEEEDDDVCSSQSSDTLVDLPG----LRRVQRLLFGCQI----------RAI 332
            ..|..|::..:..|||:...........:..|:..    :...:|.|.|.::          :..
Human  3781 RRAQCETLSPDGLPEEQPQTTKLKGKMQSRFDMAENVVIVASQKRPLGGRELQLPSMSMLTSKTS 3845

  Fly   333 TEKLTSSVIQLSDWVIYMRTDWERVIHCLVICFDLATNTNNSVVDMDYLDRVLPKLCQAASAMPV 397
            |:|....|:|:   :|.:|.|..|..........|.::...|...:....|.|.  .:|.:.:.:
Human  3846 TQKFFLRVLQV---IIQLRDDTRRANKKAKQTGRLGSSGLGSASSIQAAVRQLE--AEADAIIQM 3905

  Fly   398 PAQARLARIWAAHCSDQLHSLIAACQQQITLQVLLDEESMRENESIISVTKVLKIVFYANILASE 462
            ..:.:.||               ..||..|.:....|.|:|..||.:.|
Human  3906 VREGQRAR---------------RQQQAATSESSQSEASVRREESPMDV---------------- 3939

  Fly   463 LERPSCRVPLEDRTEAATASGSAAVEDDLFVYNSLLEPHMPKFAEDQFEKELQVSAIDCRKPLIP 527
             ::||   |....|::..:.|:...|.:    .....|.:|..:|.....||.....:|.|   .
Human  3940 -DQPS---PSAQDTQSIASDGTPQGEKE----KEERPPELPLLSEQLSLDELWDMLGECLK---E 3993

  Fly   528 LEEFYNE--------ALSENIQMHHDYLSYKTLAMES-EIGSGHANYFSFMLYAFILTPST--KV 581
            |||.:::        |:.....:|......|....:: |....|.......|....|||:|  .:
Human  3994 LEESHDQHAVLVLQPAVEAFFLVHATERESKPPVRDTRESQLAHIKDEPPPLSPAPLTPATPSSL 4058

  Fly   582 DALY--YDSRMRMYSE---------RYSSLH-SILNNI---GQVGQEDNP--------------- 616
            |..:  ..|.|.:.|.         |::..| ::||.|   ......|.|
Human  4059 DPFFSREPSSMHISSSLPPDTQKFLRFAETHRTVLNQILRQSTTHLADGPFAVLVDYIRVLDFDV 4123

  Fly   617 -----------------RPDLKLTVRRDQLINDALIGLEMVAMSNPKDLKKQLVVEFVGEQGIDE 664
                             :.|:.:.||||.:..|:...|.   ..:|:::|.:|.:.|.||:|.|.
Human  4124 KRKYFRQELERLDEGLRKEDMAVHVRRDHVFEDSYRELH---RKSPEEMKNRLYIVFEGEEGQDA 4185

  Fly   665 GGVSKEFFQLIVEEIFNPAFGMFIQQEETNNMWFNATPFENG-----AQFTLIGIIIGLAIYNNV 724
            ||:.:|::.:|..|:|||.:.:| :....:.:.:...|..:.     :.|..:|.|:..|:|:|.
Human  4186 GGLLREWYMIISREMFNPMYALF-RTSPGDRVTYTINPSSHCNPNHLSYFKFVGRIVAKAVYDNR 4249

  Fly   725 TLAVNFPMVVYRKLIGYCGTFADLSDWSPALYKSLKSMLDYQGQDMEEV-FEQTFKISYSDVFGD 788
            .|...|....|:.::|....:.|:.......|:.|..:|:   .|:..: ::.||.....: ||.
Human  4250 LLECYFTRSFYKHILGKSVRYTDMESEDYHFYQGLVYLLE---NDVSTLGYDLTFSTEVQE-FGV 4310

  Fly   789 VVQHELVPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGF-EMVTDESPLKL--LFRP 850
            ....:|.|||.::||.:.||:.:|:|.....:...|.:|..||.:|| |::    |.:|  :|..
Human  4311 CEVRDLKPNGANILVTEENKKEYVHLVCQMRMTGAIRKQLAAFLEGFYEII----PKRLISIFTE 4371

  Fly   851 EEIEMLVCGSREFDFVELENSTVYEGGYTEKSQYIQDFWSIVHAMPSEDKHKLLEFTTGSARVPV 915
            :|:|:|:.|....|..:|:::|.|. .|...|..||.||..:.:....|:.|.|:|.||:::||:
Human  4372 QELELLISGLPTIDIDDLKSNTEYH-KYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPL 4435

  Fly   916 GGLKCL-------RLLITRHGPDSDRLPTSHTCFNVLLLPEYSSREKLEERLMKAI-NYSKGFGM 972
            .|...|       :..|.|....:||||::|||||.|.||.|.|.|||...|:.|| ..|:|||:
Human  4436 QGFAALEGMNGIQKFQIHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECSEGFGL 4500

  Fly   973  972
            Human  4501  4500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166	19/129 (15%)
		HECTc	620..971	CDD:238033	111/367 (30%)
		HECTc	647..970	CDD:214523	103/339 (30%)
HUWE1	XP_016884680.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810