DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ube3a and itcha

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_001274024.1	Gene:	itcha / 100331274	ZFINID:	ZDB-GENE-120919-4	Length:	851	Species:	Danio rerio

Alignment Length:	1036	Identity:	218/1036 - (21%)
Similarity:	375/1036 - (36%)	Gaps:	329/1036 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 TPEMKRSAV-------RSLIKRYFHQ-----LQSGCGNANCSNANCASSGKVAPMTPNEVAARAL 84
            :|:.|:|..       :.:.:.:.||     :..|..:...|....|::.|:..:      .:.|
Zfish    47 SPKWKQSLTVIVTPFSKLIFRVWSHQTLKADILLGVASLEVSETLKANNMKICEV------VQTL 105

  Fly    85 QLFSQ--------DAQLC--------EAFTSEANSPQDV---------DMLSPNDSSSSS----- 119
            ||.|.        |..||        |.|.||......|         |.:...|||.||
Zfish   106 QLSSDRGRSEQVGDLSLCLDGLQVDAETFASEEQKHNAVVNGESRLNGDAIRSRDSSPSSDITDD 170

  Fly   120 ----SGSSTSTITSASTTTTTSR-----QSQSTPAAVVVPVSSPYLTQSVPQLDIAGAEHSSGDS 175
                :|.:..:..|||.:|...|     :.|..|.|      ||:...| ......|:..:.|.|
Zfish   171 APLPNGHAVGSSASASPSTGALRAPRPLRPQRPPPA------SPHKHTS-STASSTGSTPTHGSS 228

  Fly   176 EPCTPTLAPVHSLDANSLIALYEQCRAADSYDRICHAIGVVFSSVDRLGKSFIRSAEPAASSSLQ 240
            .| :|.::|                       |:|
Zfish   229 AP-SPEMSP-----------------------RVC------------------------------ 239

  Fly   241 ELLANSPGALNKEQLRTLEGEHDKDEDSTQQVDEQSESAANATATAESVESEAEPEEEDDDVCSS 305
                             :.||.:....|:.....|:..|:.....|.::.:...|
Zfish   240 -----------------VNGETESQGSSSGSGSNQAPRASPTPPRAPAITNGPLP---------- 277

  Fly   306 QSSDTLVDLPGLRRVQRLLFGCQIRAITEKLTSSVIQLSDWVIYMRTDWERVIHCLVICFDLATN 370
                     ||                                     ||:           ..:
Zfish   278 ---------PG-------------------------------------WEQ-----------RAD 285

  Fly   371 TNNSVVDMDYLDRVLPKLCQAASAMPVPAQARLARIWAAHCSDQLHSLIAACQQQITLQVLLDEE 435
            .|..|..:|::::  ....:....:|...:.||..:...:..|.::.  ....|:.||      |
Zfish   286 QNGRVYYVDHIEK--RTTWERPEPLPPGWERRLDPMGRVYYVDHINR--TTTWQRPTL------E 340

  Fly   436 SMRENESIISVTKVLKIVFYANILASELERPSCRVPLEDRTEAATASGSAAVEDDLFVYNSLLEP 500
            |:|..|                               |.:.:.:...|:....:..|:|.  |:.
Zfish   341 SVRNYE-------------------------------EWQNQRSQLQGAMQRFNQRFIYG--LQE 372

  Fly   501 HMPKFAEDQFEKELQVSAIDCRKPLIPLEEFYNEALSENIQM---HHDYLS-------YKTLAME 555
            .:...|..:|:            ||.||...:.:....|.:|   ||...|       .:.|..|
Zfish   373 QLAPTANKEFD------------PLGPLPSGWEKRTDSNRRMYFVHHPTRSTQWEDPRTQGLLNE 425

  Fly   556 SEIGSGHANYFSFMLYAFILTPSTKVDALYY----DSRMRMYSERYSSLHSILNNIGQVG----- 611
            ..:..|....|:             ||.:.|    :.|...|.:..:. .|.|.|..|:.
Zfish   426 KPLPEGWEMRFT-------------VDGIPYFVDHNRRTTTYIDPRTG-KSSLENGPQITYVRDF 476

  Fly   612 -----------QEDNPRPDLKLTVRRDQLINDALIGLEMVAMSNPKDLKKQLVVEFVGEQGIDEG 665
                       |:.:....:|:.|.|..|..|:   .:.:...:|:||:::|.:.|.||:|:|.|
Zfish   477 KAKVHYFRFWCQQLSMPQHIKIHVSRKTLFEDS---FQQIMGCHPQDLRRRLWIIFPGEEGLDYG 538

  Fly   666 GVSKEFFQLIVEEIFNPAFGMFIQQEETNNMWFNATPF-----ENGAQFTLIGIIIGLAIYNNVT 725
            ||::|:|.|:..|:.||.:.:| :....:|......|.     ::...|..||..|.:|:::...
Zfish   539 GVAREWFFLLSHEVLNPMYCLF-EYAGKDNYCLQINPASSINPDHLKYFKFIGRFIAMALFHGKF 602

  Fly   726 LAVNFPMVVYRKLIGYCGTFADLSDWSPALYKSLKSMLDYQGQDMEEV-FEQTFKISYSDVFGDV 789
            :...|.:..|::::.......||....|..|.||..:.|   .::||. .|..|.:. .::.|:|
Zfish   603 IDTGFSLPFYKRILNKPLALKDLESIDPEFYNSLIWIKD---NNIEECGLEMFFSVD-KEILGEV 663

  Fly   790 VQHELVPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGFEMVTDESPLKLLFRPEEIE 854
            ..|||.|:|.::.|.:.|||.::.|.:::.|:..:|:|..||.:||..|..:..|: .|..:|:|
Zfish   664 TTHELKPDGGNIQVTEENKEEYIRLVAEWRLSRGVEEQTQAFLEGFNDVLPQQYLQ-YFDAKELE 727

  Fly   855 MLVCGSREFDFVELENSTVYEGGYTEKSQYIQDFWSIVHAMPSEDKHKLLEFTTGSARVPVGGLK 919
            :::||.:|.|..:.:.:::|. .|...|:.|..||..|..|.:|.:.:||:|.||:.|:||||..
Zfish   728 VMLCGMQEIDLGDWQRNSIYR-HYARSSKQIVWFWQFVKEMDNEKRMRLLQFVTGTCRLPVGGFA 791

  Fly   920 CLRLLITRHGPD---------SDRLPTSHTCFNVLLLPEYSSREKLEERLMKAINYSKGFG 971
            .   |:..:||.         .:.||.||||||.|.||.|.|.|:|:|:|:.||..::|||
Zfish   792 D---LMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFG 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166	11/73 (15%)
		HECTc	620..971	CDD:238033	114/365 (31%)
		HECTc	647..970	CDD:214523	107/337 (32%)
itcha	NP_001274024.1	C2_E3_ubiquitin_ligase	2..125	CDD:175988	16/83 (19%)
		WW	276..305	CDD:278809	8/97 (8%)
		WW	308..337	CDD:278809	5/30 (17%)
		WW	387..418	CDD:197736	7/30 (23%)
		WW	427..458	CDD:197736	7/43 (16%)
		HECTc	496..849	CDD:238033	114/365 (31%)
		HECTc	520..848	CDD:214523	107/337 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910