DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ube3a and herc5.4

DIOPT Version :9

Sequence 1:	NP_648452.1	Gene:	Ube3a / 39266	FlyBaseID:	FBgn0061469	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	XP_005160166.1	Gene:	herc5.4 / 100148091	ZFINID:	ZDB-GENE-090311-7	Length:	995	Species:	Danio rerio

Alignment Length:	1043	Identity:	234/1043 - (22%)
Similarity:	395/1043 - (37%)	Gaps:	294/1043 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNGGGGGEDDQHLPGVSSASGS-AAGAVGGRATPEMKRSAVRSLIKRYFHQLQSGCG----NANC 60
            ::.||.......|.||....|| :||.:|   ..:.|...|.:::|       |.||    :.:|
Zfish   173 ISAGGNHSFVLSLSGVVFGWGSNSAGQLG---LGDTKDRFVPTIVK-------SLCGKKTVSISC 227

  Fly    61 SNANCASSGKVAPMTPNEVAARALQLFSQD--AQLCEAFTSEANSPQDVDMLSPNDSSSSSSGSS 123
            ...:.|:..|          ...:..|...  .||......:.:.|:.:..|         .||.
Zfish   228 GGEHTATLSK----------GGTVFTFGSGGFGQLGHNSLKDEHHPRLIAEL---------WGSK 273

  Fly   124 TSTITSASTTTTTSRQS----------------------QSTPAAVVVPVSSPYLTQSVPQLDIA 166
            .|.:|.....|....:|                      ||.|..|::|..   .|:...:..|.
Zfish   274 VSQVTCGRHHTLVFEESSKLIYSFGCGMQGQLGNGEQVKQSVPLPVLLPTE---CTEFTMEKLIT 335

  Fly   167 GAEHS--------SGDSE-PCTPTLAPVHSLDANSLIALYEQCRAADSYDRICHAIGVVFSSVDR 222
            |..||        ..:|| |.:.:...:.:|:...:.....:   :|.:..:.:.|..||||...
Zfish   336 GEHHSFALFFKNPGNESEKPKSGSNGGILTLNDRMIDRWVSE---SDPWPTVKNEINTVFSSAAS 397

  Fly   223 LGKSFIRSAEPAASSSLQELLANSPGALNKEQLRTLEGEHDKD--EDSTQQVDEQSESAANATAT 285
            |..||                           |:|...||.:.  |......|....|.|...|
Zfish   398 LNGSF---------------------------LKTSRDEHYQTSVEHCGLDFDLVKTSFAKLFA- 434

  Fly   286 AESVESEAEPEEEDDDVCSSQSSDTLVD-------LP----GLRRVQRLLFGCQIRAITEKLTSS 339
            ::|:.||.....:...:.|...:.|.|:       ||    ||::        |...:.|.|.|.
Zfish   435 SKSLISEVVKVVQQTLLPSLNPNPTGVEALRLYLLLPELINGLKK--------QRTKLIEALASK 491

  Fly   340 VIQLSDWVIYMRTDWERVIHCLVICFDLATNTNNSVVDMDYLDRVLPKLCQAASAMPVPAQARLA 404
            :::|:                         :....|::|.:            |.:|.....||.
Zfish   492 ILELN-------------------------SAARKVLEMYW------------SRLPDDWFERLI 519

  Fly   405 RIWAAHCSDQLHSLIAACQQQITLQVLLDEESMRENESIISVTKVLKIVFYANILASELERPSCR 469
            :::....:|.:..:   |.:       .|.:|.|..::|:   ::|::.:          :.||.
Zfish   520 KLFHKESTDLIDQI---CDE-------TDHQSTRHLKNIL---EILQMAY----------QISCS 561

  Fly   470 VPLEDRTEAATASGSAAVEDDLFVY--NSLLEPHMPKFAEDQFEKELQVSAIDCRKPLIPLEEFY 532
            ..:              ...|..::  |.||: .:.....|....||.:...:....::.|||:|
Zfish   562 TDI--------------THHDFIIHKINDLLD-LLQTITADLLRMELYMQINEDFHDMVKLEEYY 611

  Fly   533 NEALSENIQMHHDYLSYKTLAMESEIGSGHANYFSFMLYAFILTPSTKVDALYYDSRMRMYSERY 597
                         :.:.|.|..           |.|              |..:.::.||::...
Zfish   612 -------------FRTVKILVK-----------FPF--------------ASDFITKQRMFNLLQ 638

  Fly   598 SSLHSILNNIGQVGQEDNPRPDLKLTVRRDQLINDALIGLEMVAMSNPKDLKKQLVVEFVGEQGI 662
            ......:.|:.......|     .|.:.|:.::.|.|..|.    .|.......|.|.|:||.||
Zfish   639 EECFRNVPNLAMGNSFSN-----LLHINRESVLTDTLQYLR----QNTHSFMHPLQVAFIGEDGI 694

  Fly   663 DEGGVSKEFFQLIVEEIFNPAFGMFIQQE-------ETNNMWFNATPFENGAQFTLIGIIIGLAI 720
            |..|:|.|||.||.:.        ||:.:       |::.:|||.........|..:|:|.|:|:
Zfish   695 DMRGLSAEFFSLISKS--------FIEWDKKILEVHESSLVWFNPHHTRGNKNFYYLGVICGMAL 751

  Fly   721 YNNVTLAVNFPMVVYRKLIGYCGTFADLSDWSPALYKSLKSMLDYQGQDMEEVFEQTFKISYSDV 785
            ||...:.::||:.:::||:....:..||.:.||...:|||::|:   :|.|||..
Zfish   752 YNRHHINIDFPLALFKKLLQQKPSLDDLEELSPVEARSLKNLLE---EDEEEVVN---------- 803

  Fly   786 FGDVVQH--------ELVPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGFEMVTDES 842
                :||        ||||||..:.|.:.|::.:|:||.|...|.:::.||..|.:||   :...
Zfish   804 ----LQHLDFTCKGQELVPNGSQIQVNKVNRQKYVDLYVDLEFNKSVKTQFEQFTRGF---SKGC 861

  Fly   843 PLK--LLFRPEEIEMLVCGSREFDFVELENSTVYEGGYTEKSQYIQDFWSIVHAMPSEDKHKLLE 905
            ||.  .:|.|||::.|:.||.::::.||:.|..|| |.:...:.|::||::...:..|:|.|.|.
Zfish   862 PLDAWTMFHPEELQELLHGSPQYNWKELQQSASYE-GCSASDELIKNFWTVFFELSEENKKKFLM 925

  Fly   906 FTTGSARVPVGGLKCLRLLITRHG-PD-SDRLPTSHTCFNVLLLPEYSSREKLEERLMKAINYSK 968
            |..|:.|||.|||....|.|::.. || .|.||.:.|||..|:||:||....|.::|:.|||...
Zfish   926 FLYGTERVPAGGLSKRALKISQTDCPDPDDHLPEAQTCFERLVLPKYSDINTLHDKLIHAINSCA 990

  Fly   969 GFG 971
            .||
Zfish   991 VFG 993

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166	10/59 (17%)
		HECTc	620..971	CDD:238033	120/369 (33%)
		HECTc	647..970	CDD:214523	114/341 (33%)
herc5.4	XP_005160166.1	RCC1_2	117..146	CDD:290274
		RCC1	133..183	CDD:278826	2/9 (22%)
		RCC1	186..235	CDD:278826	15/58 (26%)
		RCC1	239..286	CDD:278826	10/55 (18%)
		RCC1	294..343	CDD:278826	10/51 (20%)
		HECTc	658..993	CDD:294058	120/367 (33%)
		HECTc	682..992	CDD:214523	114/338 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276447at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820