Protein Alignment Ube3a and herc3

DIOPT Version :9

• Sequence 1: NP_648452.1
• Gene: Ube3a / 39266
• FlyBaseID: FBgn0061469
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: NP_001139096.1
• Gene: herc3 / 100003587
• ZFINID: ZDB-GENE-090313-139
• Length: 1046
• Species: Danio rerio
• Alignment Length: 1106
• Identity: 272/1106 - (24%)
• Similarity: 456/1106 - (41%)
• Gaps: 276/1106 - (24%)

  Fly     6 GGEDDQHLPGVSS---------------ASGSAAGAVGGRATPEMKRSAVR--SLIKRYF-HQL- 51
            |..|.|.:.|||.               |.|:..|...|..|.|   .|||  .|||:.. |::
Zfish    79 GALDAQKISGVSCGQAHSLAVNEQGQVFAWGAGDGGQLGLGTAE---EAVRVPRLIKKLCEHRIS 140

  Fly    52 QSGCGNANCSNANCASSGKVAPMTPNEVAARALQLFSQDAQLCEAFTSEANSPQDVDM------- 109
            |..|||.:|                  :|      .|:|.||   |....||...:.:
Zfish   141 QVMCGNHHC------------------IA------LSKDGQL---FVWGENSSGQLGLGKGEPST 178

  Fly   110 LSPNDSSS---------SSSGSSTSTIT-----------SASTTTTTSRQSQSTPAAV------- 147
            |||....|         |:.|..:..::           ||........|.::.|..:
Zfish   179 LSPQPLKSLCGIPLTQISAGGDHSFALSFSGAVFGWGKNSAGQLGLNDEQDRAVPCHIKFLRSQK 243

  Fly   148 VVPVS-----SPYLTQ----------SVPQLDIAGAEHSSGDSEPCTPTLAPVHSLDANSLIALY 197
            ||.:|     :..||:          |..||.     |.|..:||....:..:...:.:.:....
Zfish   244 VVYISCGEEHTAALTKEGGLFTFGNGSKGQLG-----HDSTRNEPLPRRVMELMGTEVSQIACGR 303

  Fly   198 EQCRAADSYDRICHAIGVVFSSVDRLGKSFIRSAE-PAASSSLQELL---------------ANS 246
            ....|......:.:|.|.  ::..:||.....||: |...|::|.|.               .:|
Zfish   304 NHTLAFVPSTGLIYAFGC--NTQGQLGTGIRGSAKSPVPVSNIQPLCIGNAYTRTEHCTIAKIHS 366

  Fly   247 PGALNKEQLRTLEGEHDKDE----DSTQQVDEQSESAANATATAESVESEAEPEEEDDDVCSSQS 307
            .|..|...|.|:||....|:    ::|:.:         |...:||::|......::.|  ||.:
Zfish   367 GGDHNFLLLSTVEGLSCPDDFRILNTTKSI---------ALINSESLDSWRMKLHDNSD--SSIT 420

  Fly   308 SDTLVDLPGLRRVQRLLFGCQIRAITEKLTSSVIQLSDWVIYMRTDWERVIHCLVICFDLATNTN 372
            :|.::                :.:.|....:|.:..||                    |....||
Zfish   421 NDIIL----------------LLSSTACWNASFLDQSD--------------------DGHFKTN 449

  Fly   373 NSVVDMDY-----LDRVLPKLCQAASAMPVPAQARLARIWAAHCSDQLHSLI---AACQ----QQ 425
            ..|..:|:     |...|.|          ||.|||..    ..:....||:   ..|.    :.
Zfish   450 PKVPGIDFNAVRLLFETLMK----------PAFARLLE----QITKSFESLLIPQLPCSPPDVEA 500

  Fly   426 ITLQVLLDE-ESMRENESIISVTKVLKIVFYANILASELERPSCRVPLEDRTEAATASGSAAVED 489
            :.:.::|.| .:.:::::.|::|                      :||........|:.|..:::
Zfish   501 MRIYLILSECPAFQDSKNYITLT----------------------IPLAMAILRLDANPSKVLDN 543

  Fly   490 -----DLFVYNSLLEPH---------------MPKFAEDQFEKEL----QVSAIDCRKPLIPLEE 530
                 |..|:..|:|.:               ||.|.|......|    ::..::.:...:....
Zfish   544 WWSLMDCTVFTRLVEMYKSIVVFLLTGGKALLMPVFLESYTSAALRLLEKLHKVNLKAHRVEYNH 608

  Fly   531 FYNEALSENIQMHHDYLSYKTLAMESEI--------GSGHANYFSFMLYAFILTPSTKVDALYYD 587
            ||...::..:.:..|||  |....:::|        ||     .:...|.|||....|...|..|
Zfish   609 FYIPDIATLVDIQEDYL--KWFLRKADIKMRYPPVQGS-----VTLCAYPFILNAQAKTTVLQTD 666

  Fly   588 SRMRM-YSERYSSLHSILNNIGQVGQEDNP----RPDLKLTVRRDQLINDALIGLEMVAMSNPKD 647
            :.::| .:...::||::...:..     .|    .|.|.|.|||:.|::||   |..:.:.|..|
Zfish   667 AELQMQMAVSGANLHNVFMLLTM-----EPLLARNPFLVLHVRRNHLVSDA---LRELTIYNDVD 723

  Fly   648 LKKQLVVEFVGEQGIDEGGVSKEFFQLIVEEIFNPAFGMFIQQEETNNMWFNATPFENGAQFTLI 712
            |||.|.|.|.||:.:|.|||:||||.|:::|:.||.:|||.|..|:|.:||:...|.....|.||
Zfish   724 LKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELMNPIYGMFTQYSESNLLWFSDKCFVEHNWFHLI 788

  Fly   713 GIIIGLAIYNNVTLAVNFPMVVYRKLIGYCGTFADLSDWSPALYKSLKSMLDYQGQDMEEVFEQT 777
            |||.||||||:..:.::||:|:|:||:....|..||.:.||...:||:.:|:::| |:||.|...
Zfish   789 GIICGLAIYNSTVVDLHFPLVLYKKLLEISPTLDDLKELSPTEGRSLQQLLEFEG-DVEETFCLN 852

  Fly   778 FKISYSDVFGDVVQHELVPNGQDVLVGQHNKELFVNLYSDFLLNTNIEQQFNAFRKGFEMVTDES 842
            |.|: .:.:|.....|||..|:.:.|.:.|::.||..|..::.:..:::|::||..||..|....
Zfish   853 FAIT-REYYGITEVKELVQGGKTIAVDKTNRKEFVQAYLQYVFSDAVQEQYSAFSSGFLKVCGGE 916

  Fly   843 PLKLLFRPEEIEMLVCGSREFDFVELENSTVYEGGYTEKSQYIQDFWSIVHAMPSEDKHKLLEFT 907
            .|. ||:|.|:..:|.|:..:::.|:|.:..|:|.::.....::.||.:.|....|.|.:.|.|.
Zfish   917 ILS-LFQPSELMAMVVGNNNYNWEEMEKNASYKGEFSATHPTVKMFWEVFHEFSLEKKKQFLLFL 980

  Fly   908 TGSARVPVGGLKCLRLLITRHGPDSDRLPTSHTCFNVLLLPEYSSREKLEERLMKAINYSKGFGM 972
            |||.|:|:.|:..||::|.....:...||.:|||:|:|.:|.|.::|.|.:||.:|:...:||.:
Zfish   981 TGSDRIPIHGMASLRIVIQSTAAEEHYLPVAHTCYNMLDMPCYQTKETLRQRLTQAVEQYEGFSL 1045

  Fly   973 L 973
            :
Zfish  1046 V 1046

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ube3a	NP_648452.1	AZUL	40..94	CDD:293166	15/57 (26%)
		HECTc	620..971	CDD:238033	131/350 (37%)
		HECTc	647..970	CDD:214523	120/322 (37%)
herc3	NP_001139096.1	RCC1	4..49	CDD:278826
		RCC1_2	37..65	CDD:290274
		RCC1	52..99	CDD:278826	6/19 (32%)
		RCC1	103..152	CDD:278826	19/75 (25%)
		RCC1	155..205	CDD:278826	12/52 (23%)
		RCC1	208..257	CDD:278826	7/48 (15%)
		RCC1	260..308	CDD:278826	7/52 (13%)
		RCC1	314..374	CDD:278826	13/61 (21%)
		HECTc	699..1044	CDD:238033	131/350 (37%)
		HECTc	723..1043	CDD:214523	120/322 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276447at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820