DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Plod and PLOD3

DIOPT Version :9

Sequence 1:	NP_648451.1	Gene:	Plod / 39265	FlyBaseID:	FBgn0036147	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_001075.1	Gene:	PLOD3 / 8985	HGNCID:	9083	Length:	738	Species:	Homo sapiens

Alignment Length:	733	Identity:	332/733 - (45%)
Similarity:	475/733 - (64%)	Gaps:	26/733 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLLLLLAVTSQGDAESNWND-----KIKVFTVATEPTDGYTRYIRSARVYDIEVTTLGLGEEWKG 67
            ||.|||...:.........|     |:.|.||||..|:||.|::|||..::..|.||||||||:|
Human    13 LLPLLLPPAASASDRPRGRDPVNPEKLLVITVATAETEGYLRFLRSAEFFNYTVRTLGLGEEWRG 77

  Fly    68 GDMQKP-GGGFKLNLLREAIAPYKNEPETIILFTDSYDVIITTTLDEIFEKFKESGAKILFSAEK 131
            ||:.:. |||.|:..|::.:..|.:..:.||:|.||||||:..:..|:.:||.:||:::|||||.
Human    78 GDVARTVGGGQKVRWLKKEMEKYADREDMIIMFVDSYDVILAGSPTELLKKFVQSGSRLLFSAES 142

  Fly   132 YCWPDKSLANDYPEVEGKASRFLNSGAFIGYAPQVFALLVD-PIEDTADDQLYFTKIFLDETKRA 195
            :|||:..||..|||| |...||||||.|||:|..:..::.. ..:|..||||::|:::||...|.
Human   143 FCWPEWGLAEQYPEV-GTGKRFLNSGGFIGFATTIHQIVRQWKYKDDDDDQLFYTRLYLDPGLRE 206

  Fly   196 KLGLKLDVQSRLFQNLHGAKNDVKLKVDLESNQGVLQNVDFMTTPSIIHGNGLSKVDLNAYGNYL 260
            ||.|.||.:||:||||:||.::|.||.|  .|:..::||.:.|.|.::||||.:|:.||..|||:
Human   207 KLSLNLDHKSRIFQNLNGALDEVVLKFD--RNRVRIRNVAYDTLPIVVHGNGPTKLQLNYLGNYV 269

  Fly   261 AR--TFNGVCLLCQENLLDLEETNLPV-ISLALMVTQPVPFFDQFLEGIESLNYPKEKLHLLIYS 322
            ..  |..|.|..|.::...|.....|. :.||:.|.||.||..:||:.:..|:||.:::.|.:::
Human   270 PNGWTPEGGCGFCNQDRRTLPGGQPPPRVFLAVFVEQPTPFLPRFLQRLLLLDYPPDRVTLFLHN 334

  Fly   323 NVAFHDDDIKSFVNKHAKEYATAKFALSTDELDERQGRQLALDKARLH-QSDYIFFVDADAHIDD 386
            |..||:..|.....:....::..|.....:.|...:.|.:|:|..|.. :.::.|.:||||.:.:
Human   335 NEVFHEPHIADSWPQLQDHFSAVKLVGPEEALSPGEARDMAMDLCRQDPECEFYFSLDADAVLTN 399

  Fly   387 GEVLRELLRLNKQFVAPIFSKHKELWSNFWGALSEGGYYARSHDYVDIVKRELIGMFNVPHVTSI 451
            .:.||.|:..|::.:||:.|:|.:||||||||||...|||||.|||::|:|:.:|::|||:::..
Human   400 LQTLRILIEENRKVIAPMLSRHGKLWSNFWGALSPDEYYARSEDYVELVQRKRVGVWNVPYISQA 464

  Fly   452 YLVKKTAFDAIS--------FKHKEFDPDMAMCESLRNAGIFMYASNLRIFGHLVNADDFNTTVT 508
            |:::.   |.:.        |...:.|||||.|:|.|:.|||::.||...||.|:....::|...
Human   465 YVIRG---DTLRMELPQRDVFSGSDTDPDMAFCKSFRDKGIFLHLSNQHEFGRLLATSRYDTEHL 526

  Fly   509 RPDFYTLFSNEIDWTEKYIHPNYSLQLNESNKIQQPCPDVYWFQIVSDAFCDDLVAIMEAHNGWS 573
            .||.:.:|.|.:||.|:|||.|||..|.....::|||||||||.::|:..||:|||.||.:..||
Human   527 HPDLWQIFDNPVDWKEQYIHENYSRALEGEGIVEQPCPDVYWFPLLSEQMCDELVAEMEHYGQWS 591

  Fly   574 DGSNNDNRLEGGYEAVPTRDIHMKQVGLERLYLKFLQMFVRPLQERAFTGYFHNPPRALMNFMVR 638
            .|.:.|:||.||||.|||.||||||||.|..:|:.|:.:|.|:.|..|.|| |...||:|||:||
Human   592 GGRHEDSRLAGGYENVPTVDIHMKQVGYEDQWLQLLRTYVGPMTESLFPGY-HTKARAVMNFVVR 655

  Fly   639 YRPDEQPSLRPHHDSSTYTINIAMNRAGIDYQGGGCRFIRYNCSVTDTKKGWMLMHPGRLTHYHE 703
            |||||||||||||||||:|:|:|:|..|:||:||||||:||:|.::..:|||.|:||||||||||
Human   656 YRPDEQPSLRPHHDSSTFTLNVALNHKGLDYEGGGCRFLRYDCVISSPRKGWALLHPGRLTHYHE 720

  Fly   704 GLLVTNGTRYIMISFIDP 721
            ||..|.||||||:||:||
Human   721 GLPTTWGTRYIMVSFVDP 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plod	NP_648451.1	Glyco_tranf_GTA_type	303..>395	CDD:325014	23/92 (25%)
Plod	NP_648451.1	P4Hc	555..719	CDD:214780	103/163 (63%)
PLOD3	NP_001075.1	Required for glycosyltransferase activity. /evidence=ECO:0000269\|PubMed:18298658, ECO:0000269\|PubMed:30089812	25..290		116/267 (43%)
		UDP-sugar binding. /evidence=ECO:0000269\|PubMed:30089812, ECO:0007744\|PDB:6FXY	44..46		1/1 (100%)
		UDP-sugar binding. /evidence=ECO:0000269\|PubMed:30089812, ECO:0007744\|PDB:6FXY	112..114		1/1 (100%)
		UDP-sugar binding. /evidence=ECO:0000269\|PubMed:30089812, ECO:0007744\|PDB:6FXY	256..259		1/2 (50%)
		Accessory region. /evidence=ECO:0000269\|PubMed:30089812	295..520		80/227 (35%)
		P4Hc	573..736	CDD:214780	103/163 (63%)
		Important for dimerization. /evidence=ECO:0000269\|PubMed:30089812	672..715		24/42 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159597
Domainoid	1	1.000	508	1.000	Domainoid score	I327
eggNOG	1	0.900	-	-		E1_KOG1971
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H843
Inparanoid	1	1.050	658	1.000	Inparanoid score	I776
Isobase	1	0.950	-	0	Normalized mean entropy	S3131
OMA	1	1.010	-	-		QHG52469
OrthoDB	1	1.010	-	-		D107532at33208
OrthoFinder	1	1.000	-	-		FOG0001885
OrthoInspector	1	1.000	-	-		otm41162
orthoMCL	1	0.900	-	-		OOG6_102482
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2729
SonicParanoid	1	1.000	-	-		X1243
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.650