DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Plod and plod1a

DIOPT Version :9

Sequence 1:	NP_648451.1	Gene:	Plod / 39265	FlyBaseID:	FBgn0036147	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_001071210.2	Gene:	plod1a / 777635	ZFINID:	ZDB-GENE-030131-3165	Length:	730	Species:	Danio rerio

Alignment Length:	720	Identity:	329/720 - (45%)
Similarity:	459/720 - (63%)	Gaps:	33/720 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 QGDAESNWNDKIKVFTVATEPTDGYTRYIRSARVYDIEVTTLGLGEEWKGGD-MQKPGGGFKLNL 81
            :||        :.|.||||:.|||:.|::|||:.::..:..||.||.|:||| |..||||.|:.|
Zfish    28 EGD--------LLVLTVATQETDGFRRFLRSAKHFNYTIKVLGRGETWRGGDYMTAPGGGQKVRL 84

  Fly    82 LREAIAPYKNEPETIILFTDSYDVIITTTLDEIFEKFKESGAKILFSAEKYCWPDKSLANDYPEV 146
            |:.|:...:.| :.:|||.||||||.::...|:.:||:::..|::||||...|||:.|.:.:|.|
Zfish    85 LKSALEDIQEE-KKVILFVDSYDVIFSSGPKELLKKFQQAKHKVVFSAETLIWPDRHLEDKHPHV 148

  Fly   147 -EGKASRFLNSGAFIGYAPQVFALLVD-PIEDTADDQLYFTKIFLDETKRAKLGLKLDVQSRLFQ 209
             |||  |||.:|.|||||..:..:|.| ...|...|||::|||::::.||..:.:.||.:.||||
Zfish   149 REGK--RFLGAGGFIGYAANLKKMLSDWSGADGDSDQLFYTKIYINKEKRKSINITLDSKCRLFQ 211

  Fly   210 NLHGAKNDVKLKVDLESNQGVLQNVDFMTTPSIIHGNGLSKVDLNAYGNYLAR--TFNGVCLLCQ 272
            |||||.::|.||  .|..:...:||.:.|.|.||||||.:|:.:|..|||:..  ||...|.:|.
Zfish   212 NLHGALDEVVLK--FEDGRVRARNVLYDTLPVIIHGNGPTKLQINYLGNYIPNLWTFETGCTMCN 274

  Fly   273 EN---LLDLEETNLPVISLALMVTQPVPFFDQFLEGIESLNYPKEKLHLLIYSNVAFHDDDIKSF 334
            ::   |..|:|:..||:.:.:.:.||.||...|.|.:.:|.|||.:|.|.||:....|:..|.:|
Zfish   275 QDRRLLSGLQESEYPVVVIGIFIQQPTPFVTVFFERLFNLKYPKNRLKLFIYNQETHHEQHIHAF 339

  Fly   335 VNKHAKEYATAKFALSTDELDERQGRQLALDKARLH-QSDYIFFVDADAHIDDGEVLRELLRLNK 398
            ::.|..||...|.....:::|....|.|..|..|.. ..:|.|.:|.|..:.:.:.||.|:..||
Zfish   340 LDSHESEYQGVKLIGPEEDIDPVSSRNLGFDMCREDIDCEYFFSIDVDVVLKNEDTLRILIEHNK 404

  Fly   399 QFVAPIFSKHKELWSNFWGALSEGGYYARSHDYVDIVKRELIGMFNVPHVTSIYLVKKTAF---- 459
            .|:||:.:|...||:|||||||..|:||||.||||||:...:|::|||:|:.|:|:|....
Zfish   405 PFIAPMLTKPGRLWTNFWGALSADGFYARSEDYVDIVQGHRVGLWNVPYVSHIFLIKADTLRTDL 469

  Fly   460 -DAISFKHKEFDPDMAMCESLRNAGIFMYASNLRIFGHLVNADDFNTTVTRPDFYTLFSNEIDWT 523
             |...||....|||||.||.:||.|:||:.:|:..||.:::.|::.|.....|.:.:|.|.::|.
Zfish   470 KDPDLFKSTTLDPDMAFCEKIRNKGVFMFVTNMDTFGRVLSTDNYQTNHLHNDLWQIFENPVEWE 534

  Fly   524 EKYIHPNYSLQLNESNKIQQPCPDVYWFQIVSDAFCDDLVAIMEAHNGWSDGSNNDNRLEGGYEA 588
            |:|||||||..|.: ..|:.||||||||.|.|:..||.||..||....||.|:|.|||::||||.
Zfish   535 ERYIHPNYSRVLKD-EFIETPCPDVYWFPIFSEVACDHLVEEMENFGQWSGGANVDNRIQGGYEN 598

  Fly   589 VPTRDIHMKQVGLERLYLKFLQMFVRPLQERAFTGYFHNPPRALMN--FMVRYRPDEQPSLRPHH 651
            |||.||||.|||.|:.:.|||..::.|:.|:.|.||:   .||..:  |:|||:|||||||||||
Zfish   599 VPTIDIHMNQVGYEKEWQKFLLDYIAPVTEKMFPGYY---TRAQFDLAFVVRYKPDEQPSLRPHH 660

  Fly   652 DSSTYTINIAMNRAGIDYQGGGCRFIRYNCSVTDTKKGWMLMHPGRLTHYHEGLLVTNGTRYIMI 716
            |:||:|||||:|..|||:|||||||:||:||:...:|||..|||||||||||||..|.|.|||.:
Zfish   661 DASTFTINIALNHVGIDFQGGGCRFLRYDCSIRSPRKGWAFMHPGRLTHYHEGLPTTEGVRYIAV 725

  Fly   717 SFIDP 721
            ||:||
Zfish   726 SFVDP 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plod	NP_648451.1	Glyco_tranf_GTA_type	303..>395	CDD:325014	28/92 (30%)
Plod	NP_648451.1	P4Hc	555..719	CDD:214780	99/165 (60%)
plod1a	NP_001071210.2	P4Hc	565..728	CDD:214780	99/165 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595794
Domainoid	1	1.000	537	1.000	Domainoid score	I263
eggNOG	1	0.900	-	-		E1_KOG1971
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	692	1.000	Inparanoid score	I666
OMA	1	1.010	-	-		QHG52469
OrthoDB	1	1.010	-	-		D107532at33208
OrthoFinder	1	1.000	-	-		FOG0001885
OrthoInspector	1	1.000	-	-		otm25066
orthoMCL	1	0.900	-	-		OOG6_102482
Panther	1	1.100	-	-	LDO	PTHR10730
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2729
SonicParanoid	1	1.000	-	-		X1243
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800