DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Plod and plod3

DIOPT Version :9

Sequence 1:	NP_648451.1	Gene:	Plod / 39265	FlyBaseID:	FBgn0036147	Length:	721	Species:	Drosophila melanogaster
Sequence 2:	NP_001039229.1	Gene:	plod3 / 734090	XenbaseID:	XB-GENE-5916631	Length:	733	Species:	Xenopus tropicalis

Alignment Length:	733	Identity:	344/733 - (46%)
Similarity:	487/733 - (66%)	Gaps:	23/733 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SALLLLLLAVTSQGDA---ESNWNDKIKVFTVATEPTDGYTRYIRSARVYDIEVTTLGLGEEWKG 67
            :..||.||...:.|.|   |:...||:.|.||||:.|:||.|::|:||.::..|.|||||.||||
Frog     7 AGFLLFLLCALAGGQAVSKEAVRPDKLLVVTVATDTTEGYERFLRTARHFNYTVRTLGLGHEWKG 71

  Fly    68 GDMQKP-GGGFKLNLLREAIAPYKNEPETIILFTDSYDVIITTTLDEIFEKFKESGAKILFSAEK 131
            ||:.:. |||.|:..|:|.:..:..:.:.:|:|.|||||:|..|..|:..||.:...|::||||.
Frog    72 GDVARTVGGGQKVRWLKEELEKHSEQDDLVIMFVDSYDVVIAGTPTELLWKFHQFEHKVVFSAEG 136

  Fly   132 YCWPDKSLANDYPEV-EGKASRFLNSGAFIGYAPQVFALL-VDPIEDTADDQLYFTKIFLDETKR 194
            :|||:.|||..||.: .||  ||||||.|||:|||::.:: :...:|..||||::||::|||:.|
Frog   137 FCWPEWSLAESYPPISNGK--RFLNSGGFIGFAPQLYRMVQLWKYKDDDDDQLFYTKVYLDESLR 199

  Fly   195 AKLGLKLDVQSRLFQNLHGAKNDVKLKVDLESNQGVLQNVDFMTTPSIIHGNGLSKVDLNAYGNY 259
            .|..:.||.:|::||||:||.::|.||  .|.|:...:||.:.|.|.:|||||.:|:.||..|||
Frog   200 EKFDIALDHKSKIFQNLNGAIDEVVLK--FERNKVRARNVAYDTIPVVIHGNGPTKLQLNYLGNY 262

  Fly   260 LAR--TFNGVCLLCQENLLD---LEETNLPVISLALMVTQPVPFFDQFLEGIESLNYPKEKLHLL 319
            :..  |..|.|.:|.::|||   ||:..||.:.|.:.:.||.||..||||.:..|:||:.:|.|.
Frog   263 VPNSWTHEGGCEVCDDDLLDLSMLEDDALPQVLLGVFIEQPTPFLPQFLERLVQLDYPRNRLSLY 327

  Fly   320 IYSNVAFHDDDIKSFVNKHAKEYATAKFALSTDELDERQGRQLALDKARLHQS-DYIFFVDADAH 383
            |:::..||:..|::|...:...:.:.|.....:.|.:.:.|.:.:|..|..:: ||.|.||||..
Frog   328 IHNSEVFHEKHIQAFWENNKDSFTSIKIVGPEEALSQGEARDMGMDLCRQDETCDYYFSVDADVV 392

  Fly   384 IDDGEVLRELLRLNKQFVAPIFSKHKELWSNFWGALSEGGYYARSHDYVDIVKRELIGMFNVPHV 448
            :.:.:.|..|::.||:.:||:.|:..:||||||||||..||||||.||||||:.:..|::|||::
Frog   393 LTNPDTLYILIQENKKVIAPMVSRSGKLWSNFWGALSPEGYYARSEDYVDIVQGKRAGVWNVPYI 457

  Fly   449 TSIYLVK-KTAFDAISFKH----KEFDPDMAMCESLRNAGIFMYASNLRIFGHLVNADDFNTTVT 508
            ..:||:| :|..:.:|.|:    .:.|.|||.|:|:|:..:|::.||...||.|::...:||:..
Frog   458 AHVYLIKGETLRNELSNKNIFTLPQMDSDMAFCKSIRDKSVFLHLSNRDEFGRLISTSKYNTSRL 522

  Fly   509 RPDFYTLFSNEIDWTEKYIHPNYSLQLNESNKIQQPCPDVYWFQIVSDAFCDDLVAIMEAHNGWS 573
            ..|.:.:|.|.:||.|||||.||: ::.|.:..:|||||||||.:..:..||:.|..||....||
Frog   523 HNDLWQIFENPVDWREKYIHENYT-KIFEEDYFEQPCPDVYWFPVFKEVMCDEFVEEMENFGQWS 586

  Fly   574 DGSNNDNRLEGGYEAVPTRDIHMKQVGLERLYLKFLQMFVRPLQERAFTGYFHNPPRALMNFMVR 638
            .|.|.|.||.||||.|||.||||.|||.:..:|||||.::.|:.|:.|.||: ...:||:||:||
Frog   587 GGKNTDQRLAGGYENVPTVDIHMTQVGYQEEWLKFLQEYIAPVTEKLFPGYY-TKAKALLNFIVR 650

  Fly   639 YRPDEQPSLRPHHDSSTYTINIAMNRAGIDYQGGGCRFIRYNCSVTDTKKGWMLMHPGRLTHYHE 703
            |||||||||||||||||:|||||:|..||||:||||||:||||.|...:|||..|||||||||||
Frog   651 YRPDEQPSLRPHHDSSTFTINIALNNKGIDYEGGGCRFLRYNCRVESPRKGWSFMHPGRLTHYHE 715

  Fly   704 GLLVTNGTRYIMISFIDP 721
            ||..|.||||||:||:||
Frog   716 GLPTTRGTRYIMVSFVDP 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Plod	NP_648451.1	Glyco_tranf_GTA_type	303..>395	CDD:325014	26/92 (28%)
Plod	NP_648451.1	P4Hc	555..719	CDD:214780	104/163 (64%)
plod3	NP_001039229.1	Glyco_tranf_GTA_type	292..>416	CDD:299700	38/123 (31%)
plod3	NP_001039229.1	P4Hc	572..731	CDD:214780	104/159 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	525	1.000	Domainoid score	I299
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H843
Inparanoid	1	1.050	678	1.000	Inparanoid score	I718
OMA	1	1.010	-	-		QHG52469
OrthoDB	1	1.010	-	-		D107532at33208
OrthoFinder	1	1.000	-	-		FOG0001885
OrthoInspector	1	1.000	-	-		otm48374
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1243
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.980