Protein Alignment Plod and Plod2

DIOPT Version :10

• Sequence 1: NP_648451.1
• Gene: Plod / 39265
• FlyBaseID: FBgn0036147
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: NP_001136388.1
• Gene: Plod2 / 26432
• MGIID: 1347007
• Length: 758
• Species: Mus musculus
• Alignment Length: 752
• Identity: 325/752 - (43%)
• Similarity: 481/752 - (63%)
• Gaps: 45/752 - (5%)

  Fly     8 LLLLLLAVTSQGDAESNWN----DKIKVFTVATEPTDGYTRYIRSARVYDIEVTTLGLGEEWKGG 68
            :|.||......|.||....    ||:.|.||||:..||:.|::.||:.::..|..||.|:||:||
Mouse    14 MLALLSWAAGLGVAEETPGRIPADKLLVITVATKENDGFHRFMNSAKYFNYTVKVLGQGQEWRGG 78

  Fly    69 D-MQKPGGGFKLNLLREAIAPYKNEPETIILFTDSYDVIITTTLDEIFEKFKESGAKILFSAEKY 132
            | |...|||.|:.||:||:..|.::.:.:||||:.:||:.....:|:.:||:::..||:|:|:..
Mouse    79 DGMNSIGGGQKVRLLKEAMEHYASQEDLVILFTECFDVVFAGGPEEVLKKFQKTNHKIVFAADGL 143

  Fly   133 CWPDKSLANDYPEVE-GKASRFLNSGAFIGYAPQVFALLVD-PIEDTADDQLYFTKIFLDETKRA 195
            .||||.||:.||.|. ||  |:||||.||||||.:..|:.. .::|..||||::||:::|..||.
Mouse   144 LWPDKRLADKYPVVHIGK--RYLNSGGFIGYAPYISRLVQQWNLQDNDDDQLFYTKVYIDPLKRE 206

  Fly   196 KLGLKLDVQSRLFQNLHGAKNDVKLKVDLESNQGVLQNVDFMTTPSIIHGNGLSKVDLNAYGNYL 260
            ...:.||.:.::||.|:||.::|.||  .|:.:..::|..:.|.|..|:|||.:|:.||.:|||:
Mouse   207 AFNITLDHKCKIFQALNGATDEVVLK--FENGKSRVKNTFYETLPVAINGNGPTKILLNYFGNYV 269

  Fly   261 ARTF---NGVCLLCQENLLDLEETNL-PVISLALMVTQPVPFFDQFLEGIESLNYPKEKLHLLIY 321
            ..::   || |.||..:.:||...:: |.::|.:.:.||.||..:||..:.:|:||||.|.|.|:
Mouse   270 PNSWTQENG-CALCDVDTIDLSTVDVPPKVTLGVFIEQPTPFLPRFLNLLLTLDYPKEALQLFIH 333

  Fly   322 SNVAFHDDDIKSFVNKHAKEYATAKFALSTDELDERQGRQLALDKARLHQS-DYIFFVDADAHID 385
            :...:|:.|||.||:|...:.::.|.....:.|.:.:.|.:.:|..|..:. ||.|.||||..:.
Mouse   334 NKEVYHEKDIKVFVDKAKHDISSIKIVGPEENLSQAEARNMGMDFCRQDEKCDYYFSVDADVVLT 398

  Fly   386 DGEVLRELLRLNKQFVAPIFSKHKELWSNFWGALSEGGYYARSHDYVDIVKRELIGMFNVPHVTS 450
            :...|:.|:..|::.:||:.::|.:||||||||||..||||||.||||||:...:|::|||::.:
Mouse   399 NPRTLKFLIEQNRKIIAPLVTRHGKLWSNFWGALSPDGYYARSEDYVDIVQGNRVGIWNVPYMAN 463

  Fly   451 IYLVK-KTAFDAIS----FKHKEFDPDMAMCESLRN---------------------AGIFMYAS 489
            :||:: ||....::    |...:.|||||:|.:.|:                     .|:|||.|
Mouse   464 VYLIQGKTLRSEMNERNYFVRDKLDPDMALCRNARDMTLQREKDSPTPETFQMLSPPKGVFMYIS 528

  Fly   490 NLRIFGHLVNADDFNTTVTRPDFYTLFSNEIDWTEKYIHPNYSLQLNESNKIQQPCPDVYWFQIV 554
            |...||.|::..::||:....||:.:|.|.:||.||||:.:||....| |.::||||||:||.|.
Mouse   529 NRHEFGRLISTANYNTSHLNNDFWQIFENPVDWKEKYINRDYSKIFTE-NIVEQPCPDVFWFPIF 592

  Fly   555 SDAFCDDLVAIMEAHNGWSDGSNNDNRLEGGYEAVPTRDIHMKQVGLERLYLKFLQMFVRPLQER 619
            |:..||:||..||.:..||.|.::|:|:.||||.|||.||||||:|||.::|.|::.|:.|:..:
Mouse   593 SERACDELVEEMEHYGKWSGGKHHDSRISGGYENVPTDDIHMKQIGLENVWLHFIREFIAPVTLK 657

  Fly   620 AFTGYFHNPPRALMNFMVRYRPDEQPSLRPHHDSSTYTINIAMNRAGIDYQGGGCRFIRYNCSVT 684
            .|.||: ....||:||:|:|.|:.|.|||||||:||:|||||:|..|.|:|||||:|:|||||:.
Mouse   658 VFAGYY-TKGFALLNFVVKYSPERQRSLRPHHDASTFTINIALNNVGEDFQGGGCKFLRYNCSIE 721

  Fly   685 DTKKGWMLMHPGRLTHYHEGLLVTNGTRYIMISFIDP 721
            ..:|||..||||||||.||||.|.||||||.:|||||
Mouse   722 SPRKGWSFMHPGRLTHLHEGLPVKNGTRYIAVSFIDP 758

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Plod	NP_648451.1	GT_LH	27..257	CDD:459235	98/232 (42%)
		Glyco_tranf_GTA_type	303..>395	CDD:472172	30/92 (33%)
		P4Hc	555..719	CDD:214780	94/163 (58%)
Plod2	NP_001136388.1	GT_LH	37..266	CDD:459235	98/232 (42%)
		P4Hc	593..756	CDD:214780	94/163 (58%)