Protein Alignment Plod and Plod1

DIOPT Version :10

• Sequence 1: NP_648451.1
• Gene: Plod / 39265
• FlyBaseID: FBgn0036147
• Length: 721
• Species: Drosophila melanogaster
• Sequence 2: NP_035252.1
• Gene: Plod1 / 18822
• MGIID: 99907
• Length: 728
• Species: Mus musculus
• Alignment Length: 736
• Identity: 321/736 - (43%)
• Similarity: 471/736 - (63%)
• Gaps: 31/736 - (4%)

  Fly     7 ALLLL-----LLAVTSQGDAESNWNDKIKVFTVATEPTDGYTRYIRSARVYDIEVTTLGLGEEWK 66
            :||||     ||.|.::.||:  ..|.:.|.||||:.|:|:.|:.|||:.::.::.:|||||:|.
Mouse     3 SLLLLAPLAWLLLVQAKDDAK--LEDNLLVLTVATKETEGFRRFKRSAQFFNYKIQSLGLGEDWS 65

  Fly    67 -GGDMQKPGGGFKLNLLREAIAPYKNEPETIILFTDSYDVIITTTLDEIFEKFKESGAKILFSAE 130
             .|.....|||.|:.||::|:..:.::.:.:|||.|||||:..:...|:.:||:::.::::||||
Mouse    66 VDGGPAAAGGGQKVRLLKKALEKHADKEDLVILFVDSYDVVFASGPRELLKKFQQAKSQVVFSAE 130

  Fly   131 KYCWPDKSLANDYPEV-EGKASRFLNSGAFIGYAPQVFALLVD-PIEDTADDQLYFTKIFLDETK 193
            ::.:||:.|...||.| :||  |||.||.||||||.:..|:.: ..:|:..|||::|||||:..|
Mouse   131 EHIYPDRRLEAKYPTVPDGK--RFLGSGGFIGYAPSLSKLVAEWEGQDSDSDQLFYTKIFLNPEK 193

  Fly   194 RAKLGLKLDVQSRLFQNLHGAKNDVKLKVDLESNQGVLQNVDFMTTPSIIHGNGLSKVDLNAYGN 258
            |.::.:.||.:.|:||||.||.::|.||.::...:.  :|:.:.|.|.::||||.:|:.||..||
Mouse   194 REQINISLDHRCRIFQNLDGALDEVVLKFEMGHVRA--RNLAYDTLPVVVHGNGPTKLQLNYLGN 256

  Fly   259 YLAR--TFNGVCLLCQENLLDLE---ETNLPVISLALMVTQPVPFFDQFLEGIESLNYPKEKLHL 318
            |:.|  ||...|.:|.|.|..|:   :..||.:.:.:.:.||.||...|...:..|.||::::.|
Mouse   257 YIPRFWTFETGCTVCDEGLRSLKGIGDEALPTVLVGVFIEQPTPFLSLFFLRLLRLRYPQKQMRL 321

  Fly   319 LIYSNVAFHDDDIKSFVNKHAKEYATAKFALSTDELDERQGRQLALDKARLHQS-DYIFFVDADA 382
            .|::....|...::.|:.:|..||.:.|.......:.....|.:..|..|..|: .|.|.||||.
Mouse   322 FIHNQERHHKLQVEQFLAEHGSEYQSVKLVGPEVRMANADARNMGADLCRQDQTCTYYFSVDADV 386

  Fly   383 HIDDGEVLRELLRLNKQFVAPIFSKHKELWSNFWGALSEGGYYARSHDYVDIVKRELIGMFNVPH 447
            .:.:...||.|:..||..:||:.::|..|||||||.||..||||||.||||||:...:|::|||:
Mouse   387 ALTEPNSLRLLIEQNKNVIAPLMTRHGRLWSNFWGGLSADGYYARSEDYVDIVQGRRVGVWNVPY 451

  Fly   448 VTSIYLVKKTAFDA-----ISFKHKEFDPDMAMCESLRNAGIFMYASNLRIFGHLVNADDFNTTV 507
            :::|||:|.:|..|     ..|.:.:.|.||:.|.::|...:||:.:|...||||::.|::.||.
Mouse   452 ISNIYLIKGSALRAELQNVDLFHYSKLDSDMSFCANVRQQEVFMFLTNRHTFGHLLSLDNYQTTH 516

  Fly   508 TRPDFYTLFSNEIDWTEKYIHPNYSLQLNESNKIQQPCPDVYWFQIVSDAFCDDLVAIMEAHNGW 572
            ...|.:.:|||..||.|||||.||:..| ....::.||||||||.|.::|.||:||..||.:..|
Mouse   517 LHNDLWEVFSNPEDWKEKYIHENYTKAL-AGKLVETPCPDVYWFPIFTEAACDELVEEMEHYGQW 580

  Fly   573 SDGSNNDNRLEGGYEAVPTRDIHMKQVGLERLYLKFLQMFVRPLQERAFTGYFHNPPRALMN--F 635
            |.|.|.|||::||||.|||.||||.|:..||.:.|||..::.|:.|:.:.||:   .||..:  |
Mouse   581 SLGDNKDNRIQGGYENVPTIDIHMNQITFEREWHKFLVEYIAPMTEKLYPGYY---TRAQFDLAF 642

  Fly   636 MVRYRPDEQPSLRPHHDSSTYTINIAMNRAGIDYQGGGCRFIRYNCSVTDTKKGWMLMHPGRLTH 700
            :|||:|||||||.||||:||:|:|||:||.|.||:||||||:||||||...:|||.|:|||||||
Mouse   643 VVRYKPDEQPSLMPHHDASTFTVNIALNRVGEDYEGGGCRFLRYNCSVRAPRKGWALLHPGRLTH 707

  Fly   701 YHEGLLVTNGTRYIMISFIDP 721
            |||||..|.|||||.:||:||
Mouse   708 YHEGLPTTKGTRYIAVSFVDP 728

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Plod	NP_648451.1	GT_LH	27..257	CDD:459235	94/232 (41%)
		Glyco_tranf_GTA_type	303..>395	CDD:472172	24/92 (26%)
		P4Hc	555..719	CDD:214780	98/165 (59%)
Plod1	NP_035252.1	GT_LH1	26..255	CDD:438560	94/232 (41%)
		P4Hc	563..726	CDD:214780	98/165 (59%)