DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Adck5 and MCP2

DIOPT Version :9

Sequence 1:	NP_001261705.1	Gene:	Adck5 / 39260	FlyBaseID:	FBgn0036142	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_013354.1	Gene:	MCP2 / 850955	SGDID:	S000004243	Length:	569	Species:	Saccharomyces cerevisiae

Alignment Length:	478	Identity:	136/478 - (28%)
Similarity:	230/478 - (48%)	Gaps:	51/478 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 ENDPEYETKVKLLHKKSAERLLETCLLNGGLYIKVGQGFAAINDILPVEYTSTLSLLQDRCLPTT 152
            ||..|.|..:...||..|...|.....|||:|||:||...|:..:||.|:|.|:..|||.|..:|
Yeast    92 ENKKEREVALNKCHKMCALITLHALRSNGGIYIKLGQHIGAMTYLLPKEWTDTMIPLQDHCPEST 156

  Fly   153 QADVQKVFRKDFGQLPEEIYQEFDYQPVAAASLAQVFKARLPS----GEQVAVKVQYNDLQKRFI 213
            ..::.::|::|.|...|:::.||:..|:..||||||..|:|.:    |..||||.|:..|::...
Yeast   157 YEEIDELFKEDLGTSIEDMFLEFNKTPIGVASLAQVHVAKLKNSDGKGSSVAVKCQHPSLKEFIP 221

  Fly   214 SDLGTIIFLQDIVEFFFKDYNFGWILNDLRKNLVLELNFLQEGQNAERCAKDMEKF---SYVHVP 275
            .|:.....:.::::.||.||...|:.::|:.::.:||||.:|.:|||:......||   :.:.:|
Yeast   222 LDVMLTRTVFELLDVFFPDYPLTWLGDELQSSIYVELNFTKEAENAEKTRHYFSKFKKQTALKIP 286

  Fly   276 KVHWSYTKTRVLTLEWMDGCKISDLKTIEKEKLSLKDIDVKLFEAFAEQIFYTGF-VHADPHPGN 339
            ||..|:  .|:|.:|::.|.::.||:.|:...:|..::...|...|...||.... :|.|||.||
Yeast   287 KVIESH--KRILIMEYVGGKRLDDLEYIDSHGISRSEVSSCLSHIFNNMIFTPNVGIHCDPHGGN 349

  Fly   340 IFVRK---NRKNG--RADIILLDHGLYEELPQNVRGPLCEFWEATVLRQENRMQAAAEKIGIGDY 399
            :.:|.   .:.||  ..:|:|.|||||.......|....:||.:.:..::   |...:|...|
Yeast   350 LAIRSVKPAKDNGYHNFEIVLFDHGLYRYPSTRTRRLYAKFWLSLLFDKD---QTKMKKYAKG-- 409

  Fly   400 MRFAEVLFQQ-PIRNRGGGIRGK-------------LTQEDIDHMQE--IARNNFEHIMGTLKEM 448
              ||.:..:| |:  ....|.|:             .|||::|.|..  :.......:|..|..:
Yeast   410 --FANITDEQFPL--LAAAITGRSIDAALNYDISTSRTQEEMDVMANGILEGTLLSDLMSILSRI 470

  Fly   449 PRSMLFVVRNLNTVRAISHQHGDVVNRPR---VMARYAQKCLYMQHNRRSPVQYIRW-------- 502
            ||.:|.:::..:..|.:.....:.:...|   :|.:|..|.:|.:...|...:|.||
Yeast   471 PRVVLLILKTNDLTRHLDECLQNPLGPERTFLIMTQYCAKTVYDEKVERINSEYARWSIKWMWEN 535

  Fly   503 LSGRIYFEYCLFLSAFKLYLLDW 525
            |:..|.:|..:....|..::|.|
Yeast   536 LTNWIVYERRINQLYFYDFVLWW 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adck5	NP_001261705.1	AarF	98..469	CDD:223733	117/399 (29%)
Adck5	NP_001261705.1	ADCK1-like	144..395	CDD:270871	81/263 (31%)
MCP2	NP_013354.1	AarF	47..569	CDD:223733	136/478 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	86	1.000	Domainoid score	I1873
eggNOG	1	0.900	-	-		E1_COG0661
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2179
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000919
OrthoInspector	1	1.000	-	-		otm46793
orthoMCL	1	0.900	-	-		OOG6_100510
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.660