DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Adck5 and Coq8a

DIOPT Version :9

Sequence 1:	NP_001261705.1	Gene:	Adck5 / 39260	FlyBaseID:	FBgn0036142	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_001156762.1	Gene:	Coq8a / 67426	MGIID:	1914676	Length:	645	Species:	Mus musculus

Alignment Length:	371	Identity:	90/371 - (24%)
Similarity:	160/371 - (43%)	Gaps:	66/371 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 RQLLSLGTRIRGKRALNGLREANVQKGGRPVLRFSLLAAGAGGLAYD-GIVNDFTYCGA----SV 67
            :|:||       :||    ||..|     ||.|...| |..||||.. ||       ||    :.
Mouse   191 KQMLS-------ERA----RERKV-----PVTRIGRL-ANFGGLAVGLGI-------GALAEVAK 231

  Fly    68 RFVRSLKTAGLIAADYLRLDENDPEYETKVKLLHKKSAERLLETCLLNGGLYIKVGQGFAAINDI 132
            :.:||..:.|..|.    ||.:        ..|.:.:|||::.|.....|..:|:||..:..:|.
Mouse   232 KSLRSENSTGKKAV----LDSS--------PFLSEANAERIVSTLCKVRGAALKLGQMLSIQDDA 284

  Fly   133 LPVEYTSTLSLLQDRC------LPTTQADVQKVFRKDFGQLPEEIYQEFDYQPVAAASLAQVFKA 191
            .   ....|:.:.:|.      :|..|  :.|....|.|....:..:.|:.:|.||||:.||..|
Mouse   285 F---INPHLAKIFERVRQSADFMPLKQ--MTKTLNSDLGPHWRDKLEYFEERPFAAASIGQVHLA 344

  Fly   192 RLPSGEQVAVKVQYNDLQKRFISDLGTIIFLQD----IVEFFFKDYNFGWILNDLRKNLVLELNF 252
            |:..|.:||:|:||..:.:...||:..::.:.:    :.|..|.::    :::.||:.|.||.::
Mouse   345 RMKGGREVAMKIQYPGVAQSINSDVNNLMAVLNMSNMLPEGLFPEH----LIDVLRRELTLECDY 405

  Fly   253 LQEGQNAERCAKDMEKFSYVHVPKVHWSYTKTRVLTLEWMDGCKISDLKTIEKEKLSLKDIDVKL 317
            .:|...|::..:.::...:.:||::........|||.|.:.|..:...:.:.:|..:  :|...:
Mouse   406 QREAAYAKKFRELLKDHPFFYVPEIVDELCSPHVLTTELISGFPLDQAEGLSQEVRN--EICYNI 468

  Fly   318 FEAFAEQIFYTGFVHADPHPGNIFVRKNRKNGRADIILLDHGLYEE 363
            ......::|....:..||:..|.|....:..    :.|||.|...|
Mouse   469 LVLCLRELFEFHVMQTDPNWSNFFYDPQQHK----VALLDFGATRE 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adck5	NP_001261705.1	AarF	98..469	CDD:223733	63/276 (23%)
Adck5	NP_001261705.1	ADCK1-like	144..395	CDD:270871	52/230 (23%)
Coq8a	NP_001156762.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	99..134
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	179..200		5/19 (26%)
		KxGQ motif. /evidence=ECO:0000250\|UniProtKB:Q8NI60	273..276		1/2 (50%)
		ABC1_ADCK3	292..542	CDD:270872	52/231 (23%)
		AAAS motif. /evidence=ECO:0000250\|UniProtKB:Q8NI60	334..337		2/2 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0661
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810