DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Adck5 and Adck1

DIOPT Version :9

Sequence 1:	NP_001261705.1	Gene:	Adck5 / 39260	FlyBaseID:	FBgn0036142	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	XP_038968578.1	Gene:	Adck1 / 366698	RGDID:	1308263	Length:	523	Species:	Rattus norvegicus

Alignment Length:	523	Identity:	176/523 - (33%)
Similarity:	276/523 - (52%)	Gaps:	40/523 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 SLLAAGAGGLAYDGIVNDFTYCGASVRFVRSLKTAGLIAADYLRLDENDP----EYETKVKLLHK 102
            |:..|.:|...|.....|.:..|| ||..|::.|..:|:.|||....:.|    ||..:...:|.
  Rat    13 SMALAASGVYLYSNSYLDPSDFGA-VRVGRAVATTAVISYDYLTSLRSVPYGSEEYLQRRSQVHL 76

  Fly   103 KSAERLLETCLLNGGLYIKVGQGFAAINDILPVEYTSTLSLLQDRCLPTTQADVQKVFRKDFGQL 167
            :||.||.|.|..|.|.:|||||...|::.:||.||||||.:|..:...::..:|::|.|:|.|:.
  Rat    77 RSARRLCELCCANRGTFIKVGQHLGALDYLLPEEYTSTLKVLHSQAPQSSMQEVRQVIREDLGKE 141

  Fly   168 PEEIYQEFDYQPVAAASLAQVFKARLPSGEQVAVKVQYNDLQKRFISDLGTIIFLQDIVEFFFKD 232
            ..:::..||..|:.|||||||.||.|..|..||||||:..:|.:...|:..:..|...|:..|.|
  Rat   142 IHDLFLSFDDTPLGAASLAQVHKAVLHDGRTVAVKVQHPKVQAQSSKDILLMEVLVLAVKQLFPD 206

  Fly   233 YNFGWILNDLRKNLVLELNFLQEGQNAERCAKDMEKFSYVHVPKVHWSYTKTRVLTLEWMDGCKI 297
            :.|.|::::.:|||.|||:||.||:|||:.|..::.|.::.||::||..:..|||.:|:::|.::
  Rat   207 FEFMWLVDEAKKNLPLELDFLNEGRNAEKVAHMLKHFDFLKVPQIHWELSTKRVLLMEFVEGGQV 271

  Fly   298 SDLKTIEKEKLSLKDIDVKLFEAFAEQIFYTGFVHADPHPGNIFVRKNRKNGRADIILLDHGLYE 362
            :|...:||.::.:.:|...|.:.::|.||..||||.||||||:.|||....|:|:|:|||||||:
  Rat   272 NDRAYMEKNRIDVNEISCHLGKMYSEMIFVNGFVHCDPHPGNVLVRKRPDTGKAEIVLLDHGLYQ 336

  Fly   363 ELPQNVRGPLCEFWEATVLRQENRMQAAAEKIGIGD-YMRFAEVLFQQPIRN--RGGGIRGKLTQ 424
            .|.:..|...|..|::.:....:|::..::::|..| |..||.:|..:...:  :|.|.......
  Rat   337 VLTEEFRLDYCNLWQSLIWTDLDRVKYYSQRLGAADLYPLFACMLTARSWASVKQGIGQAPVSAT 401

  Fly   425 EDIDHMQEIARNN----FEHIMGTLKEMPRSMLFVVRNLNTVRAISHQHG------DVVNRPRVM 479
            ||    .|| |||    ...|...|..:||.||.:::..:.:|:|....|      ..:|..|..
  Rat   402 ED----SEI-RNNAACYLPEISQLLNHVPRQMLLILKTNDLLRSIETTLGTRSSASSFLNMSRCC 461

  Fly   480 ARYAQKCLYMQHNRRSPVQYIRWLSGRIYFE----------YCLFLSAFKLYLLDWYFNILYLVG 534
            .|     ...:|.:|....:.|  ..:|.|.          :.|.|....|.|..|...:|..:.
  Rat   462 IR-----ALAEHRKRDAGSFFR--RTQISFSEAFSLWQISLHELLLRVKALRLACWVSALLGWLT 519

  Fly   535 RAP 537
            |||
  Rat   520 RAP 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adck5	NP_001261705.1	AarF	98..469	CDD:223733	140/377 (37%)
Adck5	NP_001261705.1	ADCK1-like	144..395	CDD:270871	94/250 (38%)
Adck1	XP_038968578.1	ADCK1-like	117..369	CDD:270871	94/251 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0661
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D350846at33208
OrthoFinder	1	1.000	-	-		FOG0000919
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100510
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720