DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Adck5 and Adck5

DIOPT Version :9

Sequence 1:	NP_001261705.1	Gene:	Adck5 / 39260	FlyBaseID:	FBgn0036142	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_001129270.1	Gene:	Adck5 / 362943	RGDID:	1305504	Length:	582	Species:	Rattus norvegicus

Alignment Length:	574	Identity:	219/574 - (38%)
Similarity:	331/574 - (57%)	Gaps:	66/574 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PLQRVRQLLSLGTR-----IRGKRALNGLREANVQKGGRPVLRFSLLAAGAGGLAYDGIVNDFTY 62
            ||.|..:...|..|     :.|...|.|......:...|..||          ||.|||
  Rat    36 PLARTSRTRLLWRRTFSATVVGTPFLFGAHYFMAESSERRKLR----------LAVDGI------ 84

  Fly    63 CGASVRFVRSLKTAGLIAADY-------LR-LDENDPEYETKVKLLHKKSAERLLETCLLNGGLY 119
                .||.||:|....|:.||       || ::||.|:|...:...|:::|:.|:...:.|||||
  Rat    85 ----GRFGRSVKIGFFISLDYWWCTNVVLRGVEENSPKYVEIMSACHQRAADALVAGAISNGGLY 145

  Fly   120 IKVGQGFAAINDILPVEYTSTLSLLQDRCLPTTQADVQKVFRKDFGQLPEEIYQEFDYQPVAAAS 184
            :|:|||..:.|.:||.||..||.:|:|:.|.....:|.::|.:||..||.|::|||||:|:||||
  Rat   146 VKLGQGLCSFNHLLPTEYIQTLRVLEDKALTRGFREVDELFLEDFQALPSELFQEFDYEPMAAAS 210

  Fly   185 LAQVFKARLPSGEQVAVKVQYNDLQKRFISDLGTIIFLQDIVEFFFKDYNFGWILNDLRKNLVLE 249
            ||||.:|:|..|..|||||||.||:.||..|:.|:..|..:||.....:.|.|:|.||:..|..|
  Rat   211 LAQVHRAKLQDGTAVAVKVQYIDLRDRFDGDVHTLELLLRLVELMHPSFGFSWVLQDLKGTLAQE 275

  Fly   250 LNFLQEGQNAERCAKDMEKFSYVHVPKVHWSYTKTRVLTLEWMDGCKISDLKTIEKEKLSLKDID 314
            |:|..||:|:||||::::.|.:|.:|:|:|..:..||||.::.||||::|::.|:.:.|:::|:.
  Rat   276 LDFENEGRNSERCAQELKHFHHVVIPRVYWDKSSKRVLTADFCDGCKVNDMEGIKSQGLAVQDVA 340

  Fly   315 VKLFEAFAEQIFYTGFVHADPHPGNIFVRKNRKNGRADIILLDHGLYEELPQNVRGPLCEFWEAT 379
            .||.:.||||||:|||:|:||||||:.|||. .:|:|:::|||||||:.|.:..|..||:.|.|.
  Rat   341 TKLIQTFAEQIFHTGFIHSDPHPGNVLVRKG-PDGKAELVLLDHGLYQFLDEKDRSSLCQLWRAI 404

  Fly   380 VLRQENRMQAAAEKIGIGDYMRFAEVLFQQPIRNRGGGIRGK--LTQEDIDHMQEIARNNFEHIM 442
            :||.:..|:..|..:|:.|||.|:|||.|:|:|.  |.:.|.  :::|:..:||::||.:|:.||
  Rat   405 ILRDDAAMKTHAAALGVQDYMLFSEVLMQRPVRL--GQLWGSHLISREEAAYMQDMAREHFDGIM 467

  Fly   443 GTLKEMPRSMLFVVRNLNTVRAISHQHGDVVNRPRVMAR-----------------YAQKCLYMQ 490
            ..||.:||.||.|:||:||||||:...|..|:|..:||:                 |:.:.|
  Rat   468 EVLKSLPRPMLLVLRNINTVRAINSSLGTPVDRYFLMAKSAVWGWSRLVGAAYQGIYSSRLL--- 529

  Fly   491 HNRRSPVQYIRWLSGRIYFEYCLFLSAFKLYLLDWYFNILYLVGRAP-ASARTV 543
                   ::|:.:...:.||..|.|....:........::..:|.|| |.|..|
  Rat   530 -------RHIKVIWEALKFEVILRLEILAMRFTALMLRVMVRLGFAPKAEAEEV 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adck5	NP_001261705.1	AarF	98..469	CDD:223733	171/372 (46%)
Adck5	NP_001261705.1	ADCK1-like	144..395	CDD:270871	116/250 (46%)
Adck5	NP_001129270.1	AarF	128..499	CDD:223733	170/372 (46%)
Adck5	NP_001129270.1	ADCK1-like	169..420	CDD:270871	118/250 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354085
Domainoid	1	1.000	196	1.000	Domainoid score	I3046
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H34378
Inparanoid	1	1.050	380	1.000	Inparanoid score	I1991
OMA	1	1.010	-	-		QHG56770
OrthoDB	1	1.010	-	-		D350846at33208
OrthoFinder	1	1.000	-	-		FOG0000919
OrthoInspector	1	1.000	-	-		oto97089
orthoMCL	1	0.900	-	-		OOG6_100510
Panther	1	1.100	-	-	LDO	PTHR43173
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4477
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910