DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Adck5 and Adck5

DIOPT Version :9

Sequence 1:	NP_001261705.1	Gene:	Adck5 / 39260	FlyBaseID:	FBgn0036142	Length:	557	Species:	Drosophila melanogaster
Sequence 2:	NP_766548.2	Gene:	Adck5 / 268822	MGIID:	2679274	Length:	582	Species:	Mus musculus

Alignment Length:	511	Identity:	215/511 - (42%)
Similarity:	318/511 - (62%)	Gaps:	31/511 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 LAYDGIVNDFTYCGASVRFVRSLKTAGLIAADY-------LR-LDENDPEYETKVKLLHKKSAER 107
            ||.|||          .||.||:|....|:.||       || ::||.|:|...:...|:::|:.
Mouse    79 LAVDGI----------GRFGRSVKIGLFISTDYWWCTNVVLRGVEENSPKYVEIMSACHQRAADT 133

  Fly   108 LLETCLLNGGLYIKVGQGFAAINDILPVEYTSTLSLLQDRCLPTTQADVQKVFRKDFGQLPEEIY 172
            |:...:.|||||:|:|||..:.|.:||.||..||.:|:|:.|.....:|.::|.:||..||.|::
Mouse   134 LVAGAIRNGGLYVKLGQGLCSFNHLLPTEYIQTLRVLEDKALTRGFREVDELFLEDFQALPNELF 198

  Fly   173 QEFDYQPVAAASLAQVFKARLPSGEQVAVKVQYNDLQKRFISDLGTIIFLQDIVEFFFKDYNFGW 237
            |||||:|:||||||||.:|:|..|..|||||||.||:.||..|:.|:..|..:||.....:.|.|
Mouse   199 QEFDYEPMAAASLAQVHRAKLHDGTDVAVKVQYIDLRDRFDGDVQTLELLLRLVELMHPSFGFSW 263

  Fly   238 ILNDLRKNLVLELNFLQEGQNAERCAKDMEKFSYVHVPKVHWSYTKTRVLTLEWMDGCKISDLKT 302
            :|.||:..||.||:|..||:||||||::::.|.||.:|:|||..:..||||.::.:|||::|::.
Mouse   264 VLQDLKGTLVQELDFENEGRNAERCAQELKHFHYVVIPRVHWDRSSKRVLTADFCNGCKVNDMEG 328

  Fly   303 IEKEKLSLKDIDVKLFEAFAEQIFYTGFVHADPHPGNIFVRKNRKNGRADIILLDHGLYEELPQN 367
            |:.:.|:::|:..||.:.||||||:|||:|:||||||:.|||. .:|:|:::|||||||:.|.:.
Mouse   329 IKSQGLAVQDVAKKLIQTFAEQIFHTGFIHSDPHPGNVLVRKG-PDGKAELVLLDHGLYQFLDEK 392

  Fly   368 VRGPLCEFWEATVLRQENRMQAAAEKIGIGDYMRFAEVLFQQPIRNRGGGIRGK--LTQEDIDHM 430
            .|..||:.|.|.:||....|:..|..:|:.|||.|:|||.|:|:|.  |.:.|.  :::|:..:|
Mouse   393 DRSSLCQLWRAIILRDNAAMKKHAAALGVQDYMLFSEVLMQRPVRL--GQLWGSHLISREEAAYM 455

  Fly   431 QEIARNNFEHIMGTLKEMPRSMLFVVRNLNTVRAISHQHGDVVNRPRVMARYA-------QKCLY 488
            |::||.:|:.||..||.:||.||.|:||:||||||:...|..|:|..:||:.|       ....|
Mouse   456 QDMAREHFDGIMEVLKALPRPMLLVLRNINTVRAINSNLGTPVDRYFLMAKSAVWGWSRLVGAAY 520

  Fly   489 MQHNRRSPVQYIRWLSGRIYFEYCLFLSAFKLYLLDWYFNILYLVGRAP-ASARTV 543
            ......|.:::|:.|...:.||..|.|....:.|......:|..:|.|| |.|..|
Mouse   521 QGIYGSSLLRHIKVLWEALKFEMALRLEILAMRLTALMLRVLVRLGFAPKAEAEEV 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adck5	NP_001261705.1	AarF	98..469	CDD:223733	174/372 (47%)
Adck5	NP_001261705.1	ADCK1-like	144..395	CDD:270871	119/250 (48%)
Adck5	NP_766548.2	AarF	78..568	CDD:223733	213/506 (42%)
Adck5	NP_766548.2	ADCK1-like	169..420	CDD:270871	119/250 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850386
Domainoid	1	1.000	196	1.000	Domainoid score	I3133
eggNOG	1	0.900	-	-		E1_COG0661
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H34378
Inparanoid	1	1.050	387	1.000	Inparanoid score	I2000
Isobase	1	0.950	-	0	Normalized mean entropy	S2179
OMA	1	1.010	-	-		QHG56770
OrthoDB	1	1.010	-	-		D350846at33208
OrthoFinder	1	1.000	-	-		FOG0000919
OrthoInspector	1	1.000	-	-		oto93548
orthoMCL	1	0.900	-	-		OOG6_100510
Panther	1	1.100	-	-	LDO	PTHR43173
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5641
SonicParanoid	1	1.000	-	-		X4477
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750