DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wls and wls

DIOPT Version :9

Sequence 1:	NP_648445.1	Gene:	wls / 39259	FlyBaseID:	FBgn0036141	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	NP_001016910.1	Gene:	wls / 549664	XenbaseID:	XB-GENE-956982	Length:	541	Species:	Xenopus tropicalis

Alignment Length:	598	Identity:	244/598 - (40%)
Similarity:	357/598 - (59%)	Gaps:	78/598 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSGTILENLSGRKLSILVATLLLCQVLCFLLGGLYAPLPAGHVTVLGSLC---REDHARQNDTSF 62
            |:|.|:||:|.:||.::...|||.|||.||:|||.||.|..:|..:...|   |::|  .:...|
Frog     1 MAGAIIENMSTKKLCMVGVALLLLQVLAFLVGGLIAPKPTSYVNPVAMKCVDIRKNH--HSSKWF 63

  Fly    63 LLYSRGAGACIPVTREEVEQDSTKMANELVHVFQMPLPRDLRDLDYSRWQQNLIGVLQVEFGYDS 127
            |.:  |.|.|..:...:...:....||::|....:|..:    .:.|.|.|.::.|||::..:..
Frog    64 LPW--GKGQCKSIQTFDEATNGHIEANDIVFAAHIPNSQ----FEMSPWFQFMLVVLQLDIAFKL 122

  Fly   128 SSELREPPRELQLTIDMRLAYRNKGDPDNGWKLYAHGVEHRYLDCVTSHVGPTETL-------YS 185
            ::.:.:   ...:.:::.:|||:  |....||..|..:|.|.|:|:.    |.|..       |.
Frog   123 NNYIED---NSMVNLNVSVAYRD--DLKEEWKELASSMEQRKLNCIL----PVEKTVANEGRQYD 178

  Fly   186 CDMIPLFELGALHHSFYLLNLRFPLDTPSQMNLQFGHMHDLTLTAIHQNGGFTQIWLLLKTMLFP 250
            ||:|||.|||::.|.:||.|:|.|:....:.|:..|.:.||.:..|.||||||.:|..:||.|.|
Frog   179 CDVIPLMELGSVSHKYYLFNIRLPVSEKKKSNIAIGEIRDLHVVCIFQNGGFTMVWFAMKTFLTP 243

  Fly   251 FVVGIMIWFWRRVHLLQRSPALLEYMLIYLGAALTFLNLPLEYLSLVYEMPYMLLLSDIRQGIFY 315
            .::.||||:|||:.::.|||.|||.::..||.::||:|:|:|:.|:.|:..:|||..||||||||
Frog   244 SIIIIMIWYWRRITMMTRSPVLLEKVIFALGFSMTFINIPVEWFSIGYDWTWMLLFGDIRQGIFY 308

  Fly   316 AMLLTFWLVFAGEHMLIQDAPNKSTIRSRYWKHLSAVVVGCISLFVFDICERGVQLRNPFYSIWT 380
            ||||:||::|.||||:.|...|:.::   |||.:..:..|...||:||:|||||||:||||||||
Frog   309 AMLLSFWIIFCGEHMMDQTERNRISV---YWKQVGPIAFGSCCLFIFDMCERGVQLKNPFYSIWT 370

  Fly   381 TPLGAKVAMTFIVLAGVSAAIYFLFLCYMIWKVFRNIGDKRTSLPSMSQARRLHYEVPLDQKVED 445
            |.:||::||.||::||:.|.:||||||:|:::|||||..|:::||.||:|||||||
Frog   371 TDVGAEIAMAFIIVAGICACLYFLFLCFMVYQVFRNISGKQSNLPEMSKARRLHYE--------- 426

  Fly   446 WAGIVYFYTKAFFFQLHKANESKGLIYRFKFLMLATLVCAALTVAGFIMGQMAEGQWDWNDNVAI 510
                                   |||:||||||:.||.||||||..||..|:.||.|...| ::|
Frog   427 -----------------------GLIFRFKFLMIITLACAALTVVFFITTQITEGNWKLGD-LSI 467

  Fly   511 QPTSAFLTGVYGMWNIYIFALLILYAPSHKQWPTMHHSDETTQSNENIVASAASEEIE----FSH 571
            :..|||.||:|||||:|:|||:.|||||||.:...|.:|....|        :.|||:    .:|
Frog   468 ELNSAFFTGIYGMWNLYVFALMFLYAPSHKHYEDGHSNDGAGMS--------SGEEIQLTTTITH 524

  Fly   572 LPSDSNPSEISSL 584
            :   ..|:|:..|
Frog   525 I---DGPTEVYRL 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wls	NP_648445.1	MIG-14_Wnt-bd	185..539	CDD:284153	176/353 (50%)
wls	NP_001016910.1	MIG-14_Wnt-bd	178..496	CDD:369027	155/324 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	394	1.000	Domainoid score	I770
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H11779
Inparanoid	1	1.050	466	1.000	Inparanoid score	I1507
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D202545at33208
OrthoFinder	1	1.000	-	-		FOG0007239
OrthoInspector	1	1.000	-	-		oto105168
Panther	1	1.100	-	-	LDO	PTHR13449
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5341
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160