DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wls and Wls

DIOPT Version :9

Sequence 1:	NP_648445.1	Gene:	wls / 39259	FlyBaseID:	FBgn0036141	Length:	594	Species:	Drosophila melanogaster
Sequence 2:	NP_001078822.1	Gene:	Wls / 362065	RGDID:	735139	Length:	541	Species:	Rattus norvegicus

Alignment Length:	608	Identity:	247/608 - (40%)
Similarity:	364/608 - (59%)	Gaps:	85/608 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSGTILENLSGRKLSILVATLLLCQVLCFLLGGLYAPLPAGHVTVLGSLCREDHARQNDTSFLLY 65
            |:|.|:||:|.:||.|:...||:.|::.||:|||.||.|...|:.:.:.|.:.....:.|.:|:
  Rat     1 MAGAIIENMSTKKLCIVGGILLVFQIVAFLVGGLIAPAPTTAVSYVAAKCVDVRKNHHKTRWLM- 64

  Fly    66 SRGAGAC---------IPVTREEVEQDSTKMANELVHVFQMPLPRDLRDLDYSRWQQNLIGVLQV 121
            ..|...|         ||   .|:|      ||::|....:|||    .::.|.|.|.::.:||:
  Rat    65 PWGPNKCNKINDFEEAIP---REIE------ANDIVFSVHIPLP----SMEMSPWFQFMLFILQI 116

  Fly   122 EFGYDSSSELREPPRELQLTIDMRLAYRNKGDPDNGWKLYAHGVEHRYLDCV-TSHVGPTE--TL 183
            :..:..::::||   ..::::|:.|.||:  |..:.|...||....|.|.|. ||...|..  ..
  Rat   117 DIAFKLNNQIRE---NAEVSMDVSLGYRD--DMFSEWTEMAHERVPRKLRCTFTSPKTPEHEGRH 176

  Fly   184 YSCDMIPLFELGALHHSFYLLNLRFPLDTPSQMNLQFGHMHDLTLTAIHQNGGFTQIWLLLKTML 248
            |.||::|..|:|::.|.:||||:|.|::...::|:..|.:.|:.|..||||||||::|..:||.|
  Rat   177 YECDVLPFMEIGSVAHKYYLLNIRLPVNEKKKINVGIGEIKDIRLVGIHQNGGFTKVWFAMKTFL 241

  Fly   249 FPFVVGIMIWFWRRVHLLQRSPALLEYMLIYLGAALTFLNLPLEYLSLVYEMPYMLLLSDIRQGI 313
            .|.:..||:|:|||:.::.|.|.|||.::..||.::||:|:|:|:.|:.::..:|||..||||||
  Rat   242 TPSIFIIMVWYWRRITMMSRPPVLLEKVIFALGISMTFINIPVEWFSIGFDWTWMLLFGDIRQGI 306

  Fly   314 FYAMLLTFWLVFAGEHMLIQDAPNKSTIRSRYWKHLSAVVVGCISLFVFDICERGVQLRNPFYSI 378
            ||||||:||::|.||||:.|...|..   :.|||.:..:.||...||:||:|||||||.||||||
  Rat   307 FYAMLLSFWIIFCGEHMMDQHERNHI---AGYWKQVGPIAVGSFCLFIFDMCERGVQLTNPFYSI 368

  Fly   379 WTTPLGAKVAMTFIVLAGVSAAIYFLFLCYMIWKVFRNIGDKRTSLPSMSQARRLHYEVPLDQKV 443
            |||.:|.::||.||::||:...:||||||:|:::|||||..|::|||:||:.||||||
  Rat   369 WTTDVGTELAMAFIIVAGICLCLYFLFLCFMVFQVFRNISGKQSSLPAMSKVRRLHYE------- 426

  Fly   444 EDWAGIVYFYTKAFFFQLHKANESKGLIYRFKFLMLATLVCAALTVAGFIMGQMAEGQWDWNDNV 508
                                     |||:|||||||.||.|||:||..||:.|:.||.|.|. .|
  Rat   427 -------------------------GLIFRFKFLMLITLACAAMTVIFFIVSQVTEGHWKWG-GV 465

  Fly   509 AIQPTSAFLTGVYGMWNIYIFALLILYAPSHKQWPTMHHSDETTQSNENIVASAASEEIE----F 569
            .:|.:|||.||:|||||:|:|||:.|||||||.:       ...|||.:: ...:.||::    .
  Rat   466 TVQVSSAFFTGIYGMWNLYVFALMFLYAPSHKNY-------GEDQSNGDL-GVHSGEELQLTTTI 522

  Fly   570 SHLPSDSNPSEISSLTSFTRKVA 592
            :|:   ..|:||..|   |||.|
  Rat   523 THV---DGPTEIYKL---TRKEA 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wls	NP_648445.1	MIG-14_Wnt-bd	185..539	CDD:284153	172/353 (49%)
Wls	NP_001078822.1	Interaction with Wnt proteins	101..202		33/105 (31%)
Wls	NP_001078822.1	MIG-14_Wnt-bd	178..496	CDD:399568	172/353 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341819
Domainoid	1	1.000	382	1.000	Domainoid score	I801
eggNOG	1	0.900	-	-		E1_28JZN
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11779
Inparanoid	1	1.050	455	1.000	Inparanoid score	I1546
OMA	1	1.010	-	-		QHG48334
OrthoDB	1	1.010	-	-		D202545at33208
OrthoFinder	1	1.000	-	-		FOG0007239
OrthoInspector	1	1.000	-	-		oto98476
orthoMCL	1	0.900	-	-		OOG6_107228
Panther	1	1.100	-	-	LDO	PTHR13449
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5341
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770