Protein Alignment IRSp53 and Pacsin3

DIOPT Version :9

• Sequence 1: NP_729679.2
• Gene: IRSp53 / 39258
• FlyBaseID: FBgn0052082
• Length: 1076
• Species: Drosophila melanogaster
• Sequence 2: NP_001276606.1
• Gene: Pacsin3 / 80708
• MGIID: 1891410
• Length: 424
• Species: Mus musculus
• Alignment Length: 484
• Identity: 90/484 - (18%)
• Similarity: 163/484 - (33%)
• Gaps: 164/484 - (33%)

  Fly    12 GVYRNILDRFNPG---------------------ARQL----------IAAGKSY---LKALHGA 42
            |.||..:.|...|                     |:||          :..|..|   .||.|..
Mouse    20 GNYRRTVQRVEDGHRLCGDLVSCFQERARIEKAYAQQLADWARKWRGAVEKGPQYGTLEKAWHAF 84

  Fly    43 ATASRLFNEALAKI-----AMNAQQSGTGDIGSALMSVVNVNKEIQDQQMNILKAFYVDLLVPLE 102
            .||:...:|...::     ..::::..|...|:....|:...:|.:..:....||
Mouse    85 FTAAERLSELHLEVREKLHGPDSERVRTWQRGAFHRPVLGGFRESRAAEDGFRKA---------- 139

  Fly   103 TNLEKDTKVVQHEQKKFLQQHKVRMESYQKAVSTMKKQRKKKATPEN--------TEKELRSLQ- 158
                         ||.:|::.| .:|:.:|:..|.:|..|...|.|:        ::::||.||
Mouse   140 -------------QKPWLKRLK-EVEASKKSYHTARKDEKTAQTRESHAKADSSMSQEQLRKLQE 190

  Fly   159 -----LLEDQKKKLDVFCDQSYKNAMTQERR---RYGFVLERQCSIAKHWMVYHTTGKTVIDNNF 215
                 ..|.:|.|      ..|:..:.:..|   ||...:|:.                     |
Mouse   191 RVGRCTKEAEKMK------TQYEQTLAELNRYTPRYMEDMEQA---------------------F 228

  Fly   216 ENWQEIAASREIIPPAAYESGYSTSNGHNNNNISSSSSSGNNNTSGNMRR-LERIKDGDD----D 275
            |:.|  ||.|:.:  ..::....|.:.|    :..|||...:....:::: :|...|.:|    .
Mouse   229 ESCQ--AAERQRL--LFFKDVLLTLHQH----LDLSSSDKFHELHRDLQQSIEAASDEEDLRWWR 285

  Fly   276 HLQGHGAQLKKSRSIDAPYGDMRTLHERENLSGLGGTGPAHYAQNSL----------PRAKSDFN 330
            ...|.|..:...:..:......|.:..:|.    ||..|......|:          |::.|.
Mouse   286 STHGPGMAMNWPQFEEWSLDTQRAISRKEK----GGRSPDEVTLTSIVPTRDGTAPPPQSPSS-- 344

  Fly   331 LALVGTGQSSANKHKIIEEQLATLGDDQRGDQRP-------LVKALYAYMPSGENQLSFEEGDRI 388
               .|:||.                :|...::.|       .|:|||.|.....::|||..|:.:
Mouse   345 ---PGSGQD----------------EDWSDEESPRKVATGVRVRALYDYAGQEADELSFRAGEEL 390

  Fly   389 ALVGGK-AKGWQFGENLRTQHFGWFPVAY 416
            ..:..: .:||..|: |::...|.:|..|
Mouse   391 LKMSEEDEQGWCQGQ-LQSGRIGLYPANY 418

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IRSp53	NP_729679.2	I-BAR_IMD	4..222	CDD:153289	48/265 (18%)
		SH3_Irsp53_BAIAP2L	364..419	CDD:212713	17/61 (28%)
Pacsin3	NP_001276606.1	BAR	16..273	CDD:386243	56/311 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	154..184		6/29 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	312..362		12/74 (16%)
		SH3_PACSIN3	365..420	CDD:212930	16/55 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000