Protein Alignment IRSp53 and zgc:158689

DIOPT Version :9

• Sequence 1: NP_729679.2
• Gene: IRSp53 / 39258
• FlyBaseID: FBgn0052082
• Length: 1076
• Species: Drosophila melanogaster
• Sequence 2: NP_001315317.1
• Gene: zgc:158689 / 791177
• ZFINID: ZDB-GENE-070112-1902
• Length: 606
• Species: Danio rerio
• Alignment Length: 641
• Identity: 153/641 - (23%)
• Similarity: 261/641 - (40%)
• Gaps: 185/641 - (28%)

  Fly     3 AEEVTKLVDGVYRNILDRFNPGARQLIAAGKSYLKALHGAATASRLFNEALAKIAMNAQQS-GTG 66
            ::||.|:.:.||:.|||:|||..:..:..||.|.|||.|...|::.:.:||.|:...|..| |:.
Zfish     4 SDEVNKMTENVYKGILDQFNPSLKNFVTMGKHYEKALTGVTVAAKGYFDALVKLGELASDSQGSK 68

  Fly    67 DIGSALMSVVNVNKEIQDQQMNILKAFYVDLLVPLETNLEKDTKVVQHEQKKFLQQHKVRMESYQ 131
            ::|..|..:..|:::||.|..::||.|:.:||..||..||.|.|.:....||:..:.|.:.||.:
Zfish    69 ELGDTLFQMAEVHRQIQVQLEDVLKLFHSELLSQLEQKLELDIKYLTGTLKKYQSERKSKAESIE 133

  Fly   132 KAVSTMKKQRKKKATPENTEK----ELRSLQLLEDQKKKLDVFCDQSYKNAMTQERRRYGFVLER 192
            :..|.:||.|:|.....:..|    |::.::|:..::.:||......|::|:|:|||||.|:::|
Zfish   134 RCQSQLKKLRRKSQASRHPNKYGDREMQYVELMSRRQAELDSLVAVGYRSALTEERRRYCFLVDR 198

  Fly   193 QCSIAKHWMVYHTTGKTVIDNNFENWQEIAA---------------------------------- 223
            |||:.|..:.||...:.::.....:||:..|
Zfish   199 QCSVTKILINYHCKVRELLSQKLSSWQQSCAQPTKLPERALNLLRHTAPQSSGGAGLAEVLRNAK 263

  Fly   224 -----------SREIIPP-----------------AAYESGYSTSNGHNNNNISSSSSSGNNNT- 259
                       |.:.:||                 .:.....|.||....|..|||::|..::.
Zfish   264 LGITQPAEQRLSVQEVPPLLNGDSSSSRSQQQQQQRSQSDSLSPSNASQQNGHSSSTASPAHSQP 328

  Fly   260 -SGNMRRLERIKDGDDDHLQG--------------HGAQLKKSRSID-----APYGDMRTLHERE 304
             .|.:..:..........|||              |.|.|  ||::.     ||:.
Zfish   329 HQGVVSSVGHTSSSSHSSLQGLTPPLAAPHSPPLPHSAPL--SRALTPVPSAAPHA--------- 382

  Fly   305 NLSGLGGTGPAHYAQNSLP---RAKSDFNLALVGTGQSSANKHKIIEEQLATLGDDQRGDQRPL- 365
             .||||    ..|..::||   |..||.:.:.:|     :...:::                ||
Zfish   383 -ASGLG----LLYGTSTLPLPRRQSSDAHTSFLG-----STLPRVL----------------PLC 421

  Fly   366 ----VKALYAYM-------PSGEN---QLSFEEGDRIALVGGKAK-GWQFGENLRTQHFGWFPVA 415
                |:|::|:.       |:|..   .|||:.||.:.|:..:.: ||.:|:|.||...||||.:
Zfish   422 SPCRVEAMFAHSSESCDGDPAGGGGSCLLSFQPGDTLGLLISEPRDGWHYGQNERTGRKGWFPFS 486

  Fly   416 YTN------------AEVAEVTTSGGRRYENMLMSYERNGGGSGSGSGGGGLRSYQQQQDYEAQL 468
            ||.            |.:::|.::...:.:.:..:.::.                |...|.|.:.
Zfish   487 YTQPCPNTPGQDISPAVLSKVNSTSMGQLDRLPPAGQQP----------------QVSPDSEDER 535

  Fly   469 ELMESHEATYRRR----RNHSAEDSSPTRMFGDTIKQQKKYRPGSGANPRPGPPPT 520
            .::....:|:|.|    .|.....:||...|.|        |..:..:| |.|.||
Zfish   536 SIISQRISTFRPRPYSMMNPDTGRTSPRLRFKD--------RMSTDFSP-PPPSPT 582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IRSp53	NP_729679.2	I-BAR_IMD	4..222	CDD:153289	75/222 (34%)
		SH3_Irsp53_BAIAP2L	364..419	CDD:212713	25/82 (30%)
zgc:158689	NP_001315317.1	I-BAR_IMD_IRSp53	3..234	CDD:153330	76/229 (33%)
		SH3_Irsp53_BAIAP2L	425..490	CDD:212713	23/64 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596414
Domainoid	1	1.000	145	1.000	Domainoid score	I4518
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002273
OrthoInspector	1	1.000	-	-		otm24803
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR14206
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1500
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.940