Protein Alignment IRSp53 and Baiap2l2

DIOPT Version :9

• Sequence 1: NP_729679.2
• Gene: IRSp53 / 39258
• FlyBaseID: FBgn0052082
• Length: 1076
• Species: Drosophila melanogaster
• Sequence 2: XP_038935822.1
• Gene: Baiap2l2 / 685357
• RGDID: 1595091
• Length: 607
• Species: Rattus norvegicus
• Alignment Length: 644
• Identity: 139/644 - (21%)
• Similarity: 227/644 - (35%)
• Gaps: 147/644 - (22%)

  Fly    48 LFNEALAKIAMNAQQSGTGDIGSALMSVVNVNK-EIQDQQMNILKAFYVDLLVPLETNLEKDTKV 111
            |.:...||||...|.       ..|:.|:.:.| .:..|.::.::.|:.|||..:|.|.:.|.:.
  Rat    49 LCSPGCAKIAGEYQH-------IRLIGVLRIIKVGVLCQVLDTVQTFHGDLLQHMEKNTKLDMQF 106

  Fly   112 VQHEQKKFLQQHKVRMESYQKAVSTMKKQRKKKATPENTEKELRSLQLLEDQKKKLDVFCDQSYK 176
            ::...:.:..:::.|..:.:|.:|.:.:..:|:  .:|..:...|:..|..|   :..|..:|.:
  Rat   107 IKDSCQHYEIEYRHRAANLEKCMSELWRMERKR--DKNAREMKESVNRLHAQ---MQAFVSESKR 166

  Fly   177 NAMTQERRRYGFVLERQCSIAKHWMVYHTTGKTVIDNNFENWQEIAASREIIPPAAYESGYSTSN 241
            .|..:|:|||.|:.|:...::..::.:....:.::.|....|:|.:           |:..|.|.
  Rat   167 AAELEEKRRYRFLAEKHLLLSNTFLQFLGRARGMLQNRVLLWKEQS-----------EASRSPSR 220

  Fly   242 GHNNNNISSSSSSGNNNTSGNMRRLERIKDGDDDHLQGHGAQLKKSRSIDAP------YGDMRTL 300
            .|:...:  ..:.|....||                     :|..:| :|.|      ||..|:.
  Rat   221 AHSPGLL--GPALGPPYPSG---------------------RLTPTR-LDMPPRPLGEYGSPRSR 261

  Fly   301 HERENLSGLGGTGP----AHYA------QNSLPRAKSDFNLALVGTGQSSANKHKIIEEQLATLG 355
            |      |.|..||    |..|      :.||||..|..:|....|.:|.:|          :.|
  Rat   262 H------GSGSYGPEPSEARSASQLEPDRRSLPRTPSASSLYASNTQRSRSN----------SFG 310

  Fly   356 DDQRGDQRPLVKALYAYMPSGENQ--LSFEEGDRI-ALVGGKAKGWQFGENLRTQHFGWFPVAYT 417
            :...|.....|:||.:: ..|.|.  |.|..||.: .||.....||.:|:...:...||||.||.
  Rat   311 ERLGGGGARRVRALVSH-SEGANHTLLRFSAGDVVEVLVPEAQNGWLYGKLEGSSASGWFPEAYV 374

  Fly   418 NAEVAEVTTSGGRRYENMLMSYERNGGGSGSGSGGGGLRSYQQQQDYEAQLELMESHEATYRRRR 482
                        :..|.|.|:               .:..............:.|....:|..|.
  Rat   375 ------------KPLEEMPMN---------------PMNPVAPMNSMAPMSPMNELPSRSYPLRG 412

  Fly   483 NHSAED-----SSPTRMFGDTIKQQKKYRPGSGANPRPGPPPTLPAPVPNGPQSQSS----RMLN 538
            :||.:|     .:|... .|....|.:.|..|.. |...|.|. |.|:||...|..|    ..:.
  Rat   413 SHSLDDLLDRPGNPAAS-SDYWDSQSRSRTPSRV-PSRAPSPA-PPPLPNRRSSVGSMGAATDVK 474

  Fly   539 SSQSFCASNGGG------VNAAVERRKQKLLNGVQSSKNHPSGKSGVAAKTSLH-SSNDSGFANE 596
            ..||.|......      ::.....|:...|....:...||......||...|. .:...|....
  Rat   475 GYQSLCHREAASHCHQRPLSTPHPLRRSSPLGPEVAQHTHPELFQPTAAAVDLRCQAPTQGTILT 539

  Fly   597 PPPQPEVDYSDEEPATQRVAIRRRADTNSHTNTVPRDVASWTLNRNFRNSVDSQIDDKS 655
            |.|||            |:::|....|.|....|... :||.    |....||..|..|
  Rat   540 PLPQP------------RISLRLGLATWSRQKWVEAQ-SSWL----FLGPKDSSRDPAS 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IRSp53	NP_729679.2	I-BAR_IMD	4..222	CDD:153289	37/174 (21%)
		SH3_Irsp53_BAIAP2L	364..419	CDD:212713	20/57 (35%)
Baiap2l2	XP_038935822.1	BAR	<85..212	CDD:416402	27/131 (21%)
		PHA03247	<229..549	CDD:223021	87/400 (22%)
		SH3_BAIAP2L2	319..377	CDD:212847	20/70 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354165
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14206
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.900