DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IRSp53 and baiap2a

DIOPT Version :9

Sequence 1:	NP_729679.2	Gene:	IRSp53 / 39258	FlyBaseID:	FBgn0052082	Length:	1076	Species:	Drosophila melanogaster
Sequence 2:	XP_005163812.1	Gene:	baiap2a / 678518	ZFINID:	ZDB-GENE-060421-2756	Length:	549	Species:	Danio rerio

Alignment Length:	553	Identity:	146/553 - (26%)
Similarity:	243/553 - (43%)	Gaps:	128/553 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EEVTKLVDGVYRNILDRFNPGARQLIAAGKSYLKALHGAATASRLFNEALAKIAMNAQQS-GTGD 67
            :||.::.:.||:||:::|||..|..||.||:|.|||.....|::.:.:||.::...|.:| |:.|
Zfish    13 DEVHRISENVYKNIMEQFNPCLRNFIAMGKNYEKALSSVTFAAKGYFDALVRMGELASESQGSKD 77

  Fly    68 IGSALMSVVNVNKEIQDQQMNILKAFYVDLLVPLETNLEKDTKVVQHEQKKFLQQHKVRMESYQK 132
            :|..|..:..|:::||.|..::||.|:.:||..||..::.|.:.:....||:..:||.:.||.:|
Zfish    78 LGDVLFQMAEVHRQIQVQLEDMLKCFHNELLSELEKKVDLDARYLTAALKKYQIEHKSKGESLEK 142

  Fly   133 AVSTMKKQRKKKATPENT----EKELRSLQLLEDQKKKLDVFCDQSYKNAMTQERRRYGFVLERQ 193
            ..:.:||.|:|....:|.    ||||:.::.:..::.:||.|..:.||.|:::|||||.|:::||
Zfish   143 CQAELKKLRRKSQGSKNPSKYGEKELQYVEAISSKQSELDTFIAEGYKTALSEERRRYCFLVDRQ 207

  Fly   194 CSIAKHWMVYHTTGKTVIDNNFENWQEIAASREIIPPAAYESGYSTSNGHNNNNISSS---SSSG 255
            |::||:...||..||.::......||:..:....:|..|.......::|  .:.:.||   ||.|
Zfish   208 CAVAKNSSAYHGKGKDLLTQKIPVWQQACSDPNKLPDRAMMLTQQMTSG--TSTLLSSPLHSSKG 270

  Fly   256 N-----------------------------------------NNTSGNMRRLERIKDGDDDHLQG 279
            |                                         |.|:|        ..|||....|
Zfish   271 NLVISDPIPGAQPLPVPPELAAFMGGGLGQGRLMGPNGMSLVNGTTG--------VHGDDYWTDG 327

  Fly   280 ------------HGAQLKKSRSIDAPYGD---MRTLHERENLSGLGGTGPAHYAQNSLPRAKSDF 329
                        ...|.:..|.:...|.:   :|.....:|.:.:|.|       .:|||:.|
Zfish   328 VSQGRPPSPQNPSQTQSQPQRQVSDVYSNTLPVRRPQPAKNKTTVGET-------RTLPRSSS-- 383

  Fly   330 NLALVGTGQSSANKHKIIEEQLATLGDDQRGDQRPLVKALYAYMPSGENQ--LSFEEGDRIALVG 392
                                  ...|.::.|..|  |:|:::: .:|:|.  |||.|||.|.|:.
Zfish   384 ----------------------MAAGLEKNGRSR--VQAIFSH-AAGDNSTLLSFTEGDIITLLV 423

  Fly   393 GKAK-GWQFGENLRTQHFGWFPVAYTNAEVAEVTTSGGRRYENMLMSYERNGGGSGSGSGGGGLR 456
            .:|: ||.:|||.:.:..||||.:||..    :..|.|.:....|        ..|..|..|.|.
Zfish   424 PEARDGWHYGENEKNKMRGWFPFSYTRV----LPDSDGEKLRVNL--------HHGKSSSTGNLL 476

  Fly   457 SYQQQQ----DYEAQLELMESHEATYRRRRNHS 485
            ..:...    ||.....|: :...|..|:|.:|
Zfish   477 EREDMSLPMPDYGLTARLL-AQSLTQSRQRPYS 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IRSp53	NP_729679.2	I-BAR_IMD	4..222	CDD:153289	78/222 (35%)
IRSp53	NP_729679.2	SH3_Irsp53_BAIAP2L	364..419	CDD:212713	24/57 (42%)
baiap2a	XP_005163812.1	I-BAR_IMD_IRSp53	11..242	CDD:153330	78/228 (34%)
baiap2a	XP_005163812.1	SH3_Irsp53	394..452	CDD:212848	25/64 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596415
Domainoid	1	1.000	145	1.000	Domainoid score	I4518
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002273
OrthoInspector	1	1.000	-	-		otm24803
orthoMCL	1	0.900	-	-		OOG6_108785
Panther	1	1.100	-	-	O	PTHR14206
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1500
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.800