DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IRSp53 and Baiap2l1

DIOPT Version :9

Sequence 1:	NP_729679.2	Gene:	IRSp53 / 39258	FlyBaseID:	FBgn0052082	Length:	1076	Species:	Drosophila melanogaster
Sequence 2:	NP_080109.1	Gene:	Baiap2l1 / 66898	MGIID:	1914148	Length:	514	Species:	Mus musculus

Alignment Length:	440	Identity:	115/440 - (26%)
Similarity:	201/440 - (45%)	Gaps:	73/440 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EEVTKLVDGVYRNILDRFNPGARQLIAAGKSYLKALHGAATASRLFNEALAKIAMNAQQSGTG-D 67
            |||.:|.:..|||::::||||.|.||..||:|.||::....|.:.:.:.:|||...|..|... :
Mouse     6 EEVNRLTENTYRNVMEQFNPGLRNLINLGKNYEKAVNAMILAGKAYYDGVAKIGEIATGSPVSTE 70

  Fly    68 IGSALMSVVNVNKEIQDQQMNILKAFYVDLLVPLETNLEKDTKVVQHEQKKFLQQHKVRMESYQK 132
            :|..|:.:.:.:|::.:......|.|:.|::..||...|.|.|.:....|::..:|:.:::|.:|
Mouse    71 LGHVLIEISSTHKKLNETLDENFKKFHKDIIHELEKKTELDVKYMNATLKRYQAEHRNKLDSLEK 135

  Fly   133 AVSTMKKQRKKKATPENT----EKELRSLQLLEDQKKKLDVFCDQSYKNAMTQERRRYGFVLERQ 193
            :.:.:||.|:|.....|.    .||:..::.:..::.::..|.....|.|:.:|:||:.|::::.
Mouse   136 SQAELKKIRRKSQGGRNALKYEHKEIEYVETVTSRQSEIQKFIADGCKEALLEEKRRFCFLVDKH 200

  Fly   194 CSIAKHWMVYHTTGKTVIDNNFENWQEIAASREIIPPAAYESGYSTSNGHNNNNIS------SSS 252
            ||.|.|...||.....::::....|||.......:|....            |.|.      |:.
Mouse   201 CSFASHIHYYHMQSAELLNSKLPRWQETCCDATKVPEKIM------------NMIEEIKTPISTP 253

  Fly   253 SSGNNNTSGNMRRLERIKDGDD-DHLQGHGAQLKKSRSIDA---PYGDM--------RTLHEREN 305
            .||....|..:.|.:.|  |.| |.|..:..::..:.|:.|   |..||        ::..:..|
Mouse   254 VSGTPQPSPMIERSKMI--GKDYDTLSKYSPKMPPAPSVKAYTSPLIDMFNNPATAAQSSEKTNN 316

  Fly   306 LSGLGGTGPAHYAQNSLPRAKSDFNLALVGTGQSSANKHKIIEEQLATLGDDQRGDQRPLVKALY 370
            .:...|..|      ||.|:.|      |.||.:...|.|                    ||.::
Mouse   317 STANTGEDP------SLQRSVS------VATGLNMMKKQK--------------------VKTIF 349

  Fly   371 AYMPSGENQ--LSFEEGDRIALVGGKAK-GWQFGENLRTQHFGWFPVAYT 417
            .: .:|.|:  |||.:||.:.|:..:.| ||.:||:..|:..||||.:||
Mouse   350 PH-TAGNNKTLLSFAQGDVLTLLIPEEKDGWLYGEHDTTKARGWFPSSYT 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IRSp53	NP_729679.2	I-BAR_IMD	4..222	CDD:153289	63/222 (28%)
IRSp53	NP_729679.2	SH3_Irsp53_BAIAP2L	364..419	CDD:212713	22/57 (39%)
Baiap2l1	NP_080109.1	I-BAR_IMD_BAIAP2L1	6..231	CDD:153329	63/224 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	306..329		5/28 (18%)
		SH3_BAIAP2L1	343..400	CDD:212846	23/77 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	449..514
		Binds F-actin. /evidence=ECO:0000250	486..514
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850466
Domainoid	1	1.000	140	1.000	Domainoid score	I4738
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002273
OrthoInspector	1	1.000	-	-		otm44321
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14206
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1500
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.900