Protein Alignment IRSp53 and baiap2l2b

DIOPT Version :10

• Sequence 1: NP_729679.2
• Gene: IRSp53 / 39258
• FlyBaseID: FBgn0052082
• Length: 1076
• Species: Drosophila melanogaster
• Sequence 2: NP_001074273.1
• Gene: baiap2l2b / 564798
• ZFINID: ZDB-GENE-060503-339
• Length: 516
• Species: Danio rerio
• Alignment Length: 616
• Identity: 128/616 - (20%)
• Similarity: 236/616 - (38%)
• Gaps: 165/616 - (26%)

  Fly    13 VYRNILDRFNPGARQLIAAGKSYLKALHGAATASRLFNEALAKIAMNAQQS-GTGDIGSALMSVV 76
            ||.|::|:||||.::|:..|.||:||....|..|..:..||||:...|..: .:..:|..|:.:.
Zfish    16 VYNNLMDQFNPGLQKLVTLGNSYIKAFQALALTSEAYFSALAKMGEQALSTLSSRSLGDVLIQIS 80

  Fly    77 NVNKEIQDQQMNILKAFYVDLLVPLETNLEKDTKVVQHEQKKFLQQHKVRMESYQKAVSTMKKQR 141
            ...:::..:...:.:.|:|::|..::.|::.|.:.::..::.:  :.:||.::     :::::|.
Zfish    81 ETQRKLTAEAEGVFRWFHVEVLQAMDKNVKLDEEYIEGSRRVY--ELEVRNQA-----ASLERQL 138

  Fly   142 KKKATPENTEKELRSLQLLEDQKKKLDVFCDQSYKNAMTQERRRYGFVLERQCSIAKHWM-VYHT 205
            ::.|..::.|.. ..:|.|.           ||....:.:|.|||.|:.|:.|.:.:..: :.:.
Zfish   139 RRGAFRDSLESS-EYMQYLR-----------QSQHEILKEEERRYRFLAEKHCGLTQSLLYLINK 191

  Fly   206 TGKTVIDNNFENWQEIAASREIIPPAAYESGYSTSNGHNNNNISSSSSSGNNNTSGNMRRLERIK 270
            ||.: :....:.|:|                          .:|.|.||          |.....
Zfish   192 TGVS-LQQRADGWKE--------------------------KVSESRSS----------RPRTPT 219

  Fly   271 DGDDDHLQGHGAQLKKSRSIDAPYGDMRTLHERENLSGLGGTGPAHYAQNSLPRAKSDFNLALVG 335
            ..|.:      ||||.|.......||...  :||.|..:....|:.....|  |:.|......:|
Zfish   220 PLDQE------AQLKSSVGSLLQTGDREM--DREPLGRVPSRAPSPLPSRS--RSSSVGESLGLG 274

  Fly   336 TGQSSANKHKIIEEQLATLGDDQRGDQRPLVKALYAYMPSGENQ--LSFEEGDRI-ALVGGKAKG 397
            .|:|                          ::|:.:: |:..|.  |.|..||.: .|:.....|
Zfish   275 GGRS--------------------------MRAIVSH-PASSNPVLLPFARGDLLTVLIPEPRNG 312

  Fly   398 WQFGENLRTQHFGWFPVAYTNAEVAEVTTSGGRRYENMLMSYERNGGGSGSGSGGGGLRSYQQQQ 462
            |.:|.:..:...||||.||. |...:....|      :.:|:                ||:....
Zfish   313 WLYGRHDPSLRQGWFPAAYV-ASTEDFLPVG------LSISH----------------RSHSMNN 354

  Fly   463 DYEAQLELMESHEATYRRRRNHSAEDSSPTRMFGDTIKQQKKYRPGSGANPRPGPPPTLPAPVPN 527
            ..|...: .||...||       :|.|||      .:..::     :.|:.|.      .:|:|.
Zfish   355 LLEPTSQ-SESDTQTY-------SEVSSP------VVSMRR-----ASADVRS------VSPLPE 394

  Fly   528 GPQSQSSRMLNSSQSFCASNGGGVNAAVERRKQKLLNG---VQSSKNHPS--GKSGVAAKTSLHS 587
             .:::|:..|.|.|.        |...:.....:|..|   |:|....|.  .:|...:|..|.:
Zfish   395 -KKTESNNELKSGQK--------VFHEIPAPATQLRRGSADVRSISPLPDRRAESHFESKVELKN 450

  Fly   588 SND-----SGFANEPPPQPEVDYSDEEPATQ 613
            .|:     ....|.|.|:.:.|.:.|.|:||
Zfish   451 YNELPPPAPPLPNSPLPERKTDLTSERPSTQ 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IRSp53	NP_729679.2	I-BAR_IMD	4..222	CDD:153289	48/210 (23%)
		SH3_Irsp53_BAIAP2L	364..419	CDD:212713	17/57 (30%)
baiap2l2b	NP_001074273.1	I-BAR_IMD_BAIAP2L2	7..215	CDD:153328	52/254 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	200..273		22/118 (19%)
		SH3_BAIAP2L2	277..335	CDD:212847	19/85 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	355..516		35/161 (22%)
		WH2	<500..515	CDD:425359