DRSC/TRiP Functional Genomics Resources

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Protein Alignment IRSp53 and BAIAP2L1

DIOPT Version :9

Sequence 1:NP_729679.2 Gene:IRSp53 / 39258 FlyBaseID:FBgn0052082 Length:1076 Species:Drosophila melanogaster
Sequence 2:NP_061330.2 Gene:BAIAP2L1 / 55971 HGNCID:21649 Length:511 Species:Homo sapiens


Alignment Length:676 Identity:149/676 - (22%)
Similarity:251/676 - (37%) Gaps:217/676 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 EEVTKLVDGVYRNILDRFNPGARQLIAAGKSYLKALHGAATASRLFNEALAKIAMNAQQSGTG-D 67
            |||.:|.:..|||::::||||.|.||..||:|.||::....|.:.:.:.:|||...|..|... :
Human     6 EEVNRLTESTYRNVMEQFNPGLRNLINLGKNYEKAVNAMILAGKAYYDGVAKIGEIATGSPVSTE 70

  Fly    68 IGSALMSVVNVNKEIQDQQMNILKAFYVDLLVPLETNLEKDTKVVQHEQKKFLQQHKVRMESYQK 132
            :|..|:.:.:.:|::.:......|.|:.:::..||..:|.|.|.:....|::..:||.::||.:|
Human    71 LGHVLIEISSTHKKLNESLDENFKKFHKEIIHELEKKIELDVKYMNATLKRYQTEHKNKLESLEK 135

  Fly   133 AVSTMKKQRKKKATPENT----EKELRSLQLLEDQKKKLDVFCDQSYKNAMTQERRRYGFVLERQ 193
            :.:.:||.|:|.....|.    .||:..::.:..::.::..|.....|.|:.:|:||:.|::::.
Human   136 SQAELKKIRRKSQGSRNALKYEHKEIEYVETVTSRQSEIQKFIADGCKEALLEEKRRFCFLVDKH 200

  Fly   194 CSIAKHWMVYHTTGKTVIDNNFENWQEIAAS------------REIIPPAAYESGYSTSNGHNNN 246
            |..|.|...||.....::::....|||....            .||..||               
Human   201 CGFANHIHYYHLQSAELLNSKLPRWQETCVDAIKVPEKIMNMIEEIKTPA--------------- 250

  Fly   247 NISSSSSSGNNNTSGNMRRLERIKDGDDDHLQGHGAQL---KKSRSIDAPYGDMRTLHERENLSG 308
               |:..||....|..:.|...::. |.|.|.....::   ...|:..:|..||           
Human   251 ---STPVSGTPQASPMIERSNVVRK-DYDTLSKCSPKMPPAPSGRAYTSPLIDM----------- 300

  Fly   309 LGGTGPAHYAQN--------------SLPRAKSDFNLALVGTGQSSANKHKIIEEQLATLGDDQR 359
              ...||..|.|              ||.|:.|      |.||.:...|.|              
Human   301 --FNNPATAAPNSQRVNNSTGTSEDPSLQRSVS------VATGLNMMKKQK-------------- 343

  Fly   360 GDQRPLVKALYAYMPSGENQ--LSFEEGDRIALVGGKAK-GWQFGENLRTQHFGWFPVAYTNAEV 421
                  ||.::.: .:|.|:  |||.:||.|.|:..:.| ||.:||:..::..||||.:||    
Human   344 ------VKTIFPH-TAGSNKTLLSFAQGDVITLLIPEEKDGWLYGEHDVSKARGWFPSSYT---- 397

  Fly   422 AEVTTSGGRRYENMLMSYERNGGGSGSGSGGGGLRSYQQQQDYEAQLELMESHEATYRRRRNHSA 486
                                                           :|:|.:|.          
Human   398 -----------------------------------------------KLLEENET---------- 405

  Fly   487 EDSSPTRMFGDTIKQQKKYRPGSGANPRPGPPPTLPAPVPNGPQSQSSRMLNSSQSF-------- 543
                                          ...|:|.|.|...:|.|:..|:.:.|.        
Human   406 ------------------------------EAVTVPTPSPTPVRSISTVNLSENSSVVIPPPDYL 440

  Fly   544 -CASNGGGVNAAVERRKQKLLNGVQSSKNHPSGKSGVAAKTSLHSSNDSGFANEPPPQPEVDYSD 607
             |.|.|    ||.:||       ..|::...:.|: .|:|....:.||:....:||     ..|.
Human   441 ECLSMG----AAADRR-------ADSARTTSTFKA-PASKPETAAPNDANGTAKPP-----FLSG 488

  Fly   608 EEP-ATQRVAIRRRADTNSHTNTVPR 632
            |.| ||.::   |...||..:..:.|
Human   489 ENPFATVKL---RPTVTNDRSAPIIR 511

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IRSp53NP_729679.2 I-BAR_IMD 4..222 CDD:153289 63/222 (28%)
SH3_Irsp53_BAIAP2L 364..419 CDD:212713 22/57 (39%)
BAIAP2L1NP_061330.2 I-BAR_IMD_BAIAP2L1 6..231 CDD:153329 63/224 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 302..328 6/25 (24%)
SH3_BAIAP2L1 342..399 CDD:212846 23/128 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 451..511 18/75 (24%)
Binds F-actin 483..511 10/35 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165160099
Domainoid 1 1.000 141 1.000 Domainoid score I4718
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002273
OrthoInspector 1 1.000 - - otm42267
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR14206
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1500
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
87.900

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