Protein Alignment IRSp53 and BAIAP2L1

DIOPT Version :10

• Sequence 1: NP_729679.2
• Gene: IRSp53 / 39258
• FlyBaseID: FBgn0052082
• Length: 1076
• Species: Drosophila melanogaster
• Sequence 2: NP_061330.2
• Gene: BAIAP2L1 / 55971
• HGNCID: 21649
• Length: 511
• Species: Homo sapiens
• Alignment Length: 676
• Identity: 149/676 - (22%)
• Similarity: 251/676 - (37%)
• Gaps: 217/676 - (32%)

  Fly     4 EEVTKLVDGVYRNILDRFNPGARQLIAAGKSYLKALHGAATASRLFNEALAKIAMNAQQSGTG-D 67
            |||.:|.:..|||::::||||.|.||..||:|.||::....|.:.:.:.:|||...|..|... :
Human     6 EEVNRLTESTYRNVMEQFNPGLRNLINLGKNYEKAVNAMILAGKAYYDGVAKIGEIATGSPVSTE 70

  Fly    68 IGSALMSVVNVNKEIQDQQMNILKAFYVDLLVPLETNLEKDTKVVQHEQKKFLQQHKVRMESYQK 132
            :|..|:.:.:.:|::.:......|.|:.:::..||..:|.|.|.:....|::..:||.::||.:|
Human    71 LGHVLIEISSTHKKLNESLDENFKKFHKEIIHELEKKIELDVKYMNATLKRYQTEHKNKLESLEK 135

  Fly   133 AVSTMKKQRKKKATPENT----EKELRSLQLLEDQKKKLDVFCDQSYKNAMTQERRRYGFVLERQ 193
            :.:.:||.|:|.....|.    .||:..::.:..::.::..|.....|.|:.:|:||:.|::::.
Human   136 SQAELKKIRRKSQGSRNALKYEHKEIEYVETVTSRQSEIQKFIADGCKEALLEEKRRFCFLVDKH 200

  Fly   194 CSIAKHWMVYHTTGKTVIDNNFENWQEIAAS------------REIIPPAAYESGYSTSNGHNNN 246
            |..|.|...||.....::::....|||....            .||..||
Human   201 CGFANHIHYYHLQSAELLNSKLPRWQETCVDAIKVPEKIMNMIEEIKTPA--------------- 250

  Fly   247 NISSSSSSGNNNTSGNMRRLERIKDGDDDHLQGHGAQL---KKSRSIDAPYGDMRTLHERENLSG 308
               |:..||....|..:.|...::. |.|.|.....::   ...|:..:|..||
Human   251 ---STPVSGTPQASPMIERSNVVRK-DYDTLSKCSPKMPPAPSGRAYTSPLIDM----------- 300

  Fly   309 LGGTGPAHYAQN--------------SLPRAKSDFNLALVGTGQSSANKHKIIEEQLATLGDDQR 359
              ...||..|.|              ||.|:.|      |.||.:...|.|
Human   301 --FNNPATAAPNSQRVNNSTGTSEDPSLQRSVS------VATGLNMMKKQK-------------- 343

  Fly   360 GDQRPLVKALYAYMPSGENQ--LSFEEGDRIALVGGKAK-GWQFGENLRTQHFGWFPVAYTNAEV 421
                  ||.::.: .:|.|:  |||.:||.|.|:..:.| ||.:||:..::..||||.:||
Human   344 ------VKTIFPH-TAGSNKTLLSFAQGDVITLLIPEEKDGWLYGEHDVSKARGWFPSSYT---- 397

  Fly   422 AEVTTSGGRRYENMLMSYERNGGGSGSGSGGGGLRSYQQQQDYEAQLELMESHEATYRRRRNHSA 486
                                                           :|:|.:|.
Human   398 -----------------------------------------------KLLEENET---------- 405

  Fly   487 EDSSPTRMFGDTIKQQKKYRPGSGANPRPGPPPTLPAPVPNGPQSQSSRMLNSSQSF-------- 543
                                          ...|:|.|.|...:|.|:..|:.:.|.
Human   406 ------------------------------EAVTVPTPSPTPVRSISTVNLSENSSVVIPPPDYL 440

  Fly   544 -CASNGGGVNAAVERRKQKLLNGVQSSKNHPSGKSGVAAKTSLHSSNDSGFANEPPPQPEVDYSD 607
             |.|.|    ||.:||       ..|::...:.|: .|:|....:.||:....:||     ..|.
Human   441 ECLSMG----AAADRR-------ADSARTTSTFKA-PASKPETAAPNDANGTAKPP-----FLSG 488

  Fly   608 EEP-ATQRVAIRRRADTNSHTNTVPR 632
            |.| ||.::   |...||..:..:.|
Human   489 ENPFATVKL---RPTVTNDRSAPIIR 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IRSp53	NP_729679.2	I-BAR_IMD	4..222	CDD:153289	63/222 (28%)
		SH3_Irsp53_BAIAP2L	364..419	CDD:212713	22/57 (39%)
BAIAP2L1	NP_061330.2	I-BAR_IMD_BAIAP2L1	6..231	CDD:153329	63/224 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	302..328		6/25 (24%)
		SH3_BAIAP2L1	342..399	CDD:212846	23/128 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	451..511		18/75 (24%)
		Binds F-actin	483..511		10/35 (29%)
		WH2	<495..510	CDD:425359	3/17 (18%)