Protein Alignment IRSp53 and PACSIN3

DIOPT Version :9

• Sequence 1: NP_729679.2
• Gene: IRSp53 / 39258
• FlyBaseID: FBgn0052082
• Length: 1076
• Species: Drosophila melanogaster
• Sequence 2: NP_001171903.1
• Gene: PACSIN3 / 29763
• HGNCID: 8572
• Length: 424
• Species: Homo sapiens
• Alignment Length: 333
• Identity: 65/333 - (19%)
• Similarity: 121/333 - (36%)
• Gaps: 103/333 - (30%)

  Fly   102 ETNLEKDTKVVQHEQKKFLQQHKVRMESYQKAVSTMKKQRKKKATPENTEKELR--SLQLLEDQK 164
            |::.:.|:.|.| ||.:.||:...|         ..|:..|.||..|.|..||.  :.:.:||.
Human   171 ESHAKADSAVSQ-EQLRKLQERVER---------CAKEAEKTKAQYEQTLAELHRYTPRYMEDM- 224

  Fly   165 KKLDVFCDQSYKNAMTQERRRYGFVLERQCSIAKHWMVYHTTGKTVID-NNFENWQEIAASREII 228
                   :|:::.....||:|..|..:...::.:|           :| ::.|.:.|:  .|::
Human   225 -------EQAFETCQAAERQRLLFFKDMLLTLHQH-----------LDLSSSEKFHEL--HRDL- 268

  Fly   229 PPAAYESGYSTSNGHNNNNISSSSSSGNNNTSGNMRRLERIKDGDDDHLQ------GHGAQLKKS 287
                            :..|.::|                    |::.|:      |.|..:...
Human   269 ----------------HQGIEAAS--------------------DEEDLRWWRSTHGPGMAMNWP 297

  Fly   288 RSIDAPYGDMRTLHERENLSGLGGTGPAHYAQNSL--------PRAKSDFNLALVGTGQSSANKH 344
            :..:......||:..:|.    ||..|......|:        |..:|.   ...||||
Human   298 QFEEWSLDTQRTISRKEK----GGRSPDEVTLTSIVPTRDGTAPPPQSP---GSPGTGQ------ 349

  Fly   345 KIIEEQLATLGDDQRGDQRPLVKALYAYMPSGENQLSFEEGDRIALVGGK-AKGWQFGENLRTQH 408
               :|:.:.....::......|:|||.|.....::|||..|:.:..:..: .:||..|: |::..
Human   350 ---DEEWSDEESPRKAATGVRVRALYDYAGQEADELSFRAGEELLKMSEEDEQGWCQGQ-LQSGR 410

  Fly   409 FGWFPVAY 416
            .|.:|..|
Human   411 IGLYPANY 418

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IRSp53	NP_729679.2	I-BAR_IMD	4..222	CDD:153289	28/122 (23%)
		SH3_Irsp53_BAIAP2L	364..419	CDD:212713	16/54 (30%)
PACSIN3	NP_001171903.1	BAR	16..273	CDD:416402	29/149 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	155..184		4/13 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	311..364		12/68 (18%)
		SH3	365..420	CDD:418401	16/55 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000