DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IRSp53 and Mtss2

DIOPT Version :9

Sequence 1:	NP_729679.2	Gene:	IRSp53 / 39258	FlyBaseID:	FBgn0052082	Length:	1076	Species:	Drosophila melanogaster
Sequence 2:	XP_006531074.1	Gene:	Mtss2 / 244654	MGIID:	3039591	Length:	751	Species:	Mus musculus

Alignment Length:	830	Identity:	168/830 - (20%)
Similarity:	259/830 - (31%)	Gaps:	284/830 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AEEVTKLVDGVYRNIL----------DRFNPGARQLIAAGKSYLKALHGAATASRLFNEALAKIA 57
            ||:....:.|:::.|:          :.||..|.:|    .|.|:....||.|   |.:|..|:|
Mouse     4 AEKECGALGGLFQAIVNDMKSSYPIWEDFNSKAAKL----HSQLRTTVLAAVA---FLDAFQKVA 61

  Fly    58 MNA--QQSGTGDIGSALMSVVNVNKEIQDQQMNILKAFYVDLLVPLETNLEKDTKVVQHEQKKFL 120
            ..|  .:..|.||||||..:...::.|:.:......|....|:.||:..:|...|......|...
Mouse    62 DMATNTRGATRDIGSALTRMCMRHRSIETKLRQFTNALLESLINPLQERIEDWKKSANQLDKDHA 126

  Fly   121 QQHK-VRMESYQKAVSTMKKQRKKKATPENTEKEL-----------RSLQLLEDQKKKLDVFCDQ 173
            :::| .|.|..:|:..|:|.|:|.:       |||           .:||.:.|....|:....|
Mouse   127 KEYKRARHEIKKKSSDTLKLQKKAR-------KELLGKGDLQPQLDSALQDVNDMYLLLEETEKQ 184

  Fly   174 SYKNAMTQERRRYGFVLERQCSIAKHWMVYHTTGKTVIDNNFENWQEIAASREII---------- 228
            :.:.|:.:||.|:       |:       :.|..:.|::.......||...:.||
Mouse   185 AVRRALIEERGRF-------CT-------FITFLQPVVNGELTMLGEITHLQGIIDDLVVLTADP 235

  Fly   229 ---PPAA-----------YESGY-------STSNGHNNNNISSSSSSGNNNTSG----------- 261
               |||:           |...|       |:||...::..|:.||||:....|
Mouse   236 HKLPPASEQVIKDLKGSDYSWSYQTPPSSPSSSNSRKSSMCSAPSSSGSAKGGGAPWPGGAQTYS 300

  Fly   262 -------------NMRRLERIKDGDDDHLQGH--------------GAQLKKSRS---------- 289
                         ...||..:...|...:...              .:|.|.|.|
Mouse   301 PSSTCRYRSLAQPATTRLSSVSSHDSGFVSQDPTYSKPPSPMPSDITSQQKSSSSASSEASETCQ 365

  Fly   290 ----IDAPYGDM-------------------RTLHERENLSGLGGTGPAHYAQNSLPRAKSDFNL 331
                ..:|..|.                   |..|.|:...|..|.|....:...:||.:.
Mouse   366 SVSECSSPTSDWTKAGPHEQPSATTLQRRKDRVEHLRDTEPGPTGGGTVGSSGEEVPRTRM---- 426

  Fly   332 ALVGTGQSSANKHKIIEEQLATLGDDQRGDQ-RPLVKALYAYMPSGENQLSFEEGDRIALVGGKA 395
                :..:.|.||               |:: .|....|...:..|.: |..::..|.:|
Mouse   427 ----SPATIAAKH---------------GEEVSPAASDLAMVLTRGLS-LEHQKSSRDSL----- 466

  Fly   396 KGWQFGENLRTQHFGWFPVAYTNAEVAEVT-TSGGRRYENMLMSYERNGGGSGSGSGGGGLRSYQ 459
               |:.....||        .|....:|.| .|.|..|:    .|..||.....|.     ..:.
Mouse   467 ---QYSSGYSTQ--------TTTPSCSEDTIPSQGSDYD----CYSVNGDADSEGP-----PEFD 511

  Fly   460 QQQDYEAQLELMESHEATYRRRRNHSAED----SSPTRMFG---------DTIKQQKKYRPG--- 508
            :.........:.:::....:.:|..|...    ..||.| |         .||::....:|.
Mouse   512 KSSTIPRNSNIAQNYRRLIQTKRPASTAGLPTAGLPTAM-GLPSGAPPGVATIRRTPSTKPTVRR 575

  Fly   509 --SGANPRPGPPPTLPAPVPNGPQS-------------------------------QSSRMLN-- 538
              |.|.|.|..||.:|...|..|.|                               .|.:.|:
Mouse   576 ALSSAGPIPIRPPIVPVKTPTVPDSPGYVGPTRAGSEECVFYTDEVASPLAPDLAKASPKRLSLP 640

  Fly   539 ----SSQS-FCASNGGG--VNAAVERRKQKLLNGVQS---------SKNHPSGKSGVAAKTSLHS 587
                .||| ..||.|||  |..|.|..:|:|.....|         :..|..|:......|:|.:
Mouse   641 NTAWGSQSPEVASYGGGAAVGLATEDEEQQLAANRHSLVEKLGELVAGAHALGEGQFPFPTALSA 705

  Fly   588 SNDSGFANEPPPQPEVDYSDEEPATQRVAIR-----RRADTNSHTNTVPR 632
            :.    :.|.|..|....||.......||||     ||..||.  .:.||
Mouse   706 TP----SEETPTPPPAATSDPPAEDMLVAIRRGVRLRRTVTND--RSAPR 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IRSp53	NP_729679.2	I-BAR_IMD	4..222	CDD:153289	56/241 (23%)
IRSp53	NP_729679.2	SH3_Irsp53_BAIAP2L	364..419	CDD:212713	10/54 (19%)
Mtss2	XP_006531074.1	I-BAR_IMD_MIM	6..239	CDD:153327	58/260 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910