Protein Alignment IRSp53 and Baiap2l2

DIOPT Version :9

• Sequence 1: NP_729679.2
• Gene: IRSp53 / 39258
• FlyBaseID: FBgn0052082
• Length: 1076
• Species: Drosophila melanogaster
• Sequence 2: NP_808248.1
• Gene: Baiap2l2 / 207495
• MGIID: 2652819
• Length: 522
• Species: Mus musculus
• Alignment Length: 584
• Identity: 128/584 - (21%)
• Similarity: 226/584 - (38%)
• Gaps: 129/584 - (22%)

  Fly     2 EAEEVTKLVDGVYRNILDRFNPGARQLIAAGKSYLKALHGAATASRLFNEALAKIAMNAQQSGTG 66
            |.::..:....:|::|:::|||....|:..|.:||:|.|..:.|:.::..|:.||...|.||.|.
Mouse     4 EMDQFYRSTMAIYKSIMEQFNPALENLVYLGNNYLRAFHALSEAAEVYFSAIQKIGEQALQSSTS 68

  Fly    67 DI-GSALMSVVNVNKEIQDQQMNILKAFYVDLLVPLETNLEKDTKVVQHEQKKFLQQHKVRMESY 130
            .| |..|:.:.:..:.:......:::.|:.|||..:|.|.:.|.:.::...:.:..:::.|..:.
Mouse    69 QILGEILVQMSDTQRHLNSDLEVVVQTFHGDLLQHMEKNTKLDMQFIKDSCQHYEIEYRHRAANL 133

  Fly   131 QKAVSTMKKQRKKKATPENTEKELRSLQLLEDQKKKLDVFCDQSYKNAMTQERRRYGFVLERQCS 195
            :|.:|.:.:..:|:  .:|..:...|:..|..|   :..|..:|.:.|..:|:|||.|:.|:...
Mouse   134 EKCMSELWRMERKR--DKNAREMKESVNRLHAQ---MQAFVSESKRAAELEEKRRYRFLAEKHLL 193

  Fly   196 IAKHWMVYHTTGKTVIDNNFENWQEIAASREIIPPAAYESGYSTSNGHNNNNISSSSSSGNNNTS 260
            ::..::.:....:.::.|....|:|.:           |:..|.|..|:...:  ..:.|....|
Mouse   194 LSNTFLQFLGRARGMLQNRVLLWKEQS-----------EASRSPSRAHSPGLL--GPALGPPYPS 245

  Fly   261 GNMRRLERIKDGDDDHLQGHGAQLKKSRSIDAP------YGDMRTLHERENLSGLGGTGP----A 315
            |                     :|..:| :|.|      ||..|:.|      |.|..||    |
Mouse   246 G---------------------RLTPTR-LDMPPRPLGEYGSPRSRH------GSGSYGPEPAEA 282

  Fly   316 HYA------QNSLPRAKSDFNLALVGTGQSSANKHKIIEEQLATLGDDQRGDQRPLVKALYAYMP 374
            ..|      :.||||..|..:|....|.:|.:|          :.|:...|.....|:||.:: .
Mouse   283 RSASQLEPDRRSLPRTPSASSLYASSTQRSRSN----------SFGERLGGGGARRVRALVSH-S 336

  Fly   375 SGENQ--LSFEEGDRI-ALVGGKAKGWQFGENLRTQHFGWFPVAYTNAEVAEVTTSGGRRYENML 436
            .|.|.  |.|..||.: .||.....||.:|:...:...||||.||.. .|.|:..:
Mouse   337 EGANHTLLRFSAGDVVEVLVPEAQNGWLYGKLEGSSASGWFPEAYVK-PVEEIPVN--------- 391

  Fly   437 MSYERNGGGSGSGSGGGGLRSYQQQQDYEAQLELMESHEATYRRRRNHSAED-----SSPTRMFG 496
                             .:..............:.|....:|..|.:||.:|     .:||....
Mouse   392 -----------------PMNPVAPMNSMAPMSPMNELPSRSYPLRGSHSLDDLLDRPGNPTASSE 439

  Fly   497 DTIKQQKKYRPGSGANPRPGP-PPTLPAPVPNGPQSQSSRMLNSSQSFCASNGGGVNAAVERRK 559
            ....|.:...|....:..|.| ||.||          |||         .|:.|.:.||.:.:|
Mouse   440 YWDSQSRSRTPSRVPSRAPSPAPPPLP----------SSR---------RSSVGSMGAATDVKK 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IRSp53	NP_729679.2	I-BAR_IMD	4..222	CDD:153289	49/218 (22%)
		SH3_Irsp53_BAIAP2L	364..419	CDD:212713	20/57 (35%)
Baiap2l2	NP_808248.1	I-BAR_IMD_BAIAP2L2	6..220	CDD:153328	49/218 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	220..325		32/155 (21%)
		SH3_BAIAP2L2	327..385	CDD:212847	20/59 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	404..502		24/100 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850467
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44321
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR14206
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.900