Protein Alignment IRSp53 and Baiap2

DIOPT Version :10

• Sequence 1: NP_729679.2
• Gene: IRSp53 / 39258
• FlyBaseID: FBgn0052082
• Length: 1076
• Species: Drosophila melanogaster
• Sequence 2: XP_006247931.1
• Gene: Baiap2 / 117542
• RGDID: 619814
• Length: 535
• Species: Rattus norvegicus
• Alignment Length: 529
• Identity: 142/529 - (26%)
• Similarity: 253/529 - (47%)
• Gaps: 94/529 - (17%)

  Fly     3 AEEVTKLVDGVYRNILDRFNPGARQLIAAGKSYLKALHGAATASRLFNEALAKIAMNAQQS-GTG 66
            :||:.:|.:.||:.|:::|||..|..||.||:|.|||.|...|::.:.:||.|:...|.:| |:.
  Rat     6 SEEMHRLTENVYKTIMEQFNPSLRNFIAMGKNYEKALAGVTFAAKGYFDALVKMGELASESQGSK 70

  Fly    67 DIGSALMSVVNVNKEIQDQQMNILKAFYVDLLVPLETNLEKDTKVVQHEQKKFLQQHKVRMESYQ 131
            ::|..|..:..|:::||:|...:||||:.:||..||..:|.|::.:....||:..:.:.:.::..
  Rat    71 ELGDVLFQMAEVHRQIQNQLEEMLKAFHNELLTQLEQKVELDSRYLSAALKKYQTEQRSKGDALD 135

  Fly   132 KAVSTMKKQRKKKATPEN----TEKELRSLQLLEDQKKKLDVFCDQSYKNAMTQERRRYGFVLER 192
            |..:.:||.|||....:|    ::|||:.:..:.:::.:|:.:....||.|:|:||||:.|::|:
  Rat   136 KCQAELKKLRKKSQGSKNPQKYSDKELQYIDAISNKQGELENYVSDGYKTALTEERRRFCFLVEK 200

  Fly   193 QCSIAKHWMVYHTTGKTVIDNNFENWQEIAASREIIPPAAYESGYSTSNGHNN---NNISSSSSS 254
            ||::||:...||:.||.::......||:..|....||..|.:.....:|.:.:   :.:|:|.|:
  Rat   201 QCAVAKNSAAYHSKGKELLAQKLPLWQQACADPNKIPDRAAQLMQQMANSNGSILPSALSASKSN 265

  Fly   255 -----------------------GNNNTSGNMRRLERIKDGD-DDHLQGHGAQLKKSRSIDAPYG 295
                                   |..:...|:..:..:...| :|:......:..:.:|:..|..
  Rat   266 LVISDPIPGAKPLPVPPELAPFVGRMSAQENVPVMNGVAGADSEDYNPWADRKAAQPKSLSPPQS 330

  Fly   296 DMR-------TLHERENLSGLGGTGPAHYA---QNSLPRAKSDFNLALVGTGQSSANKHKIIEEQ 350
            ..:       ||..|:::     |....||   ..:|||:.|
  Rat   331 QSKLSDSYSNTLPVRKSV-----TPKNSYATTENKTLPRSSS----------------------- 367

  Fly   351 LATLGDDQRGDQRPLVKALYAYMPSGENQ--LSFEEGDRIALVGGKAK-GWQFGENLRTQHFGWF 412
             ...|.::.|..|  |||:::: .:|:|.  |||:|||.|.|:..:|: ||.:||:.:|:..|||
  Rat   368 -MAAGLERNGRMR--VKAIFSH-AAGDNSTLLSFKEGDLITLLVPEARDGWHYGESEKTKMRGWF 428

  Fly   413 PVAYTNAEVAEVTTSGGRRYENMLMSYERNGGGSGSGSGGGGLRSYQQ----QQDYEAQLELMES 473
            |.:||     .|..|.|.  :.:.||.::     |..|..|.|.....    ..||........|
  Rat   429 PFSYT-----RVLDSDGS--DRLHMSLQQ-----GKSSSTGNLLDKDDLALPPPDYGTSSRAFPS 481

  Fly   474 HEA-TYRRR 481
            ..| |:::|
  Rat   482 QTAGTFKQR 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IRSp53	NP_729679.2	I-BAR_IMD	4..222	CDD:153289	75/222 (34%)
		SH3_Irsp53_BAIAP2L	364..419	CDD:212713	25/57 (44%)
Baiap2	XP_006247931.1	I-BAR_IMD_IRSp53	5..236	CDD:153330	76/229 (33%)
		SH3_Irsp53	378..436	CDD:212848	26/65 (40%)