DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IRSp53 and Baiap2

DIOPT Version :9

Sequence 1:	NP_729679.2	Gene:	IRSp53 / 39258	FlyBaseID:	FBgn0052082	Length:	1076	Species:	Drosophila melanogaster
Sequence 2:	NP_001032844.2	Gene:	Baiap2 / 108100	MGIID:	2137336	Length:	535	Species:	Mus musculus

Alignment Length:	557	Identity:	154/557 - (27%)
Similarity:	258/557 - (46%)	Gaps:	111/557 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AEEVTKLVDGVYRNILDRFNPGARQLIAAGKSYLKALHGAATASRLFNEALAKIAMNAQQS-GTG 66
            :||:.:|.:.||:.|:::|||..|..||.||:|.|||.|...|::.:.:||.|:...|.:| |:.
Mouse     6 SEEMHRLTENVYKTIMEQFNPSLRNFIAMGKNYEKALAGVTFAAKGYFDALVKMGELASESQGSK 70

  Fly    67 DIGSALMSVVNVNKEIQDQQMNILKAFYVDLLVPLETNLEKDTKVVQHEQKKFLQQHKVRMESYQ 131
            ::|..|..:..|:::||:|....||:|:.:||..||..:|.|::.:....||:..:.:.:.::..
Mouse    71 ELGDVLFQMAEVHRQIQNQLEETLKSFHNELLTQLEQKVELDSRYLSAALKKYQTEQRSKGDALD 135

  Fly   132 KAVSTMKKQRKKKATPEN----TEKELRSLQLLEDQKKKLDVFCDQSYKNAMTQERRRYGFVLER 192
            |..:.:||.|||....:|    ::|||:.:..:.:::.:|:.:....||.|:|:||||:.|::|:
Mouse   136 KCQAELKKLRKKSQGSKNPQKYSDKELQYIDAISNKQGELENYVSDGYKTALTEERRRFCFLVEK 200

  Fly   193 QCSIAKHWMVYHTTGKTVIDNNFENWQEIAASREIIPPAAYESGYSTSNGHNNNNISSSSSSGNN 257
            ||::||:...||:.||.::......||:..|....||..|.:.....:|. |.:.:.|:.|:..:
Mouse   201 QCAVAKNSAAYHSKGKELLAQKLPLWQQACADPNKIPDRAVQLMQQMANS-NGSILPSALSASKS 264

  Fly   258 NT---------------------SGNMRRLERIK-----DGDDDHLQGHGAQLK--KSRSIDAPY 294
            |.                     .|.|...|.:.     .|.|.......|..|  :.:|:..|.
Mouse   265 NLVISDPIPGAKPLPVPPELAPFVGRMSAQENVPVMNGVAGPDSEDYNPWADRKAAQPKSLSPPQ 329

  Fly   295 GDMR-------TLHERENLSGLGGTGPAHYA---QNSLPRAKSDFNLALVGTGQSSANKHKIIEE 349
            ...:       ||..|:::     |....||   ..:|||:.|
Mouse   330 SQSKLSDSYSNTLPVRKSV-----TPKNSYATTENKTLPRSSS---------------------- 367

  Fly   350 QLATLGDDQRGDQRPLVKALYAYMPSGENQ--LSFEEGDRIALVGGKAK-GWQFGENLRTQHFGW 411
              ...|.::.|..|  |||:::: .:|:|.  |||:|||.|.|:..:|: ||.:||:.:|:..||
Mouse   368 --MAAGLERNGRMR--VKAIFSH-AAGDNSTLLSFKEGDLITLLVPEARDGWHYGESEKTKMRGW 427

  Fly   412 FPVAYTNAEVAEVTTSGGRRYENMLMSYERNGGGSGSGSGGGGLRSYQQQQDYEAQLELMESHEA 476
            ||.:||     .|..|.|.  :.:.||.::     |..|..|.|..       :..|.|......
Mouse   428 FPFSYT-----RVLDSDGS--DRLHMSLQQ-----GKSSSTGNLLD-------KDDLALPPPDYG 473

  Fly   477 TYRRRRNHSAEDSSPTRMFGDTIKQQKKYRPGSGANP 513
            |..|        :.||:..| |.||    ||.|.|.|
Mouse   474 TSSR--------AFPTQTAG-TFKQ----RPYSVAVP 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IRSp53	NP_729679.2	I-BAR_IMD	4..222	CDD:153289	74/222 (33%)
IRSp53	NP_729679.2	SH3_Irsp53_BAIAP2L	364..419	CDD:212713	25/57 (44%)
Baiap2	NP_001032844.2	I-BAR_IMD_IRSp53	5..236	CDD:153330	75/229 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	299..370		16/99 (16%)
		SH3_Irsp53	378..436	CDD:212848	26/65 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	445..477		9/43 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850468
Domainoid	1	1.000	140	1.000	Domainoid score	I4738
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002273
OrthoInspector	1	1.000	-	-		otm44321
orthoMCL	1	0.900	-	-		OOG6_108785
Panther	1	1.100	-	-	O	PTHR14206
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4928
SonicParanoid	1	1.000	-	-		X1500
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.830