DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IRSp53 and LOC100485322

DIOPT Version :9

Sequence 1:	NP_729679.2	Gene:	IRSp53 / 39258	FlyBaseID:	FBgn0052082	Length:	1076	Species:	Drosophila melanogaster
Sequence 2:	XP_002935048.2	Gene:	LOC100485322 / 100485322	-ID:	-	Length:	545	Species:	Xenopus tropicalis

Alignment Length:	457	Identity:	138/457 - (30%)
Similarity:	234/457 - (51%)	Gaps:	66/457 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AEEVTKLVDGVYRNILDRFNPGARQLIAAGKSYLKALHGAATASRLFNEALAKIAMNAQQS-GTG 66
            ::||.:|.:.|||.|||:|||..|..:..||.|.|||.|...|::.:.:||.|:...|..| |:.
Frog     4 SDEVNRLTENVYRAILDQFNPSLRNFVTMGKHYEKALSGVTVAAKGYFDALVKLGELASISQGSK 68

  Fly    67 DIGSALMSVVNVNKEIQDQQMNILKAFYVDLLVPLETNLEKDTKVVQHEQKKFLQQHKVRMESYQ 131
            ::|..|..:..|:::||.|...:||.|:.:||..||..||.|.|.:....||:..:|:.:.||.:
Frog    69 ELGDTLFQMAEVHRQIQVQLEEVLKLFHSELLAQLEHKLELDIKYLTATLKKYQVEHRSKSESIE 133

  Fly   132 KAVSTMKKQRKKKATPENTEK----ELRSLQLLEDQKKKLDVFCDQSYKNAMTQERRRYGFVLER 192
            |..|.:||.|||....:|.:|    |::.::::..::.:||.|..:.||.|:|:|||||.|:::|
Frog   134 KCQSELKKLRKKCQNSKNPQKYGDREVQYVEIMSTKQCELDQFVAEGYKAALTEERRRYSFLVDR 198

  Fly   193 QCSIAKHWMVYHTTGKTVIDNNFENWQEIAASREIIPPAAYESGYSTSNGHNNNNISSS------ 251
            ||:::||:..||:..|.::......||:.......:|..|......|:: |....:.|.
Frog   199 QCAVSKHFSAYHSKVKELLSAKLPTWQQSCTQPTKLPERALMLVKQTAS-HTTEPVISDPMPSTK 262

  Fly   252 ------------SSSGNNNTSGNMRRLERIKDGDDDHLQGHGAQLKKSRSIDAPYGDMRTLH-ER 303
                        :.|.||..|  ::.:..|.:|:....:|       ||.:.:|      .| |.
Frog   263 PLEVPPELAPLLACSVNNRMS--VQEVLPIPNGETHRSRG-------SRDMGSP------PHIEP 312

  Fly   304 ENLSGLGGTGPAHYAQNSLPRAKSD--FNLALVGTGQSSANKHKIIEEQLATLGDDQ-------- 358
            ..|..:..:.||..|..:.|.:|::  ::..|....:.|:      |.:||||.:::
Frog   313 LLLIPVVSSQPATPASVTPPPSKANEMYSCTLPMPRKPSS------ENRLATLVENKTLPRISPL 371

  Fly   359 -----RGDQRPLVKALYAYMPSGENQ--LSFEEGDRIALVGGKAK-GWQFGENLRTQHFGWFPVA 415
                 |.::| .|:|:::: .:.||.  |:|:|||.|.|:..:|: ||.:|||..|:..||||.:
Frog   372 SVLPPRVERR-RVQAVFSH-NAAENSTLLNFKEGDIILLLVPEARDGWHYGENETTKMKGWFPFS 434

  Fly   416 YT 417
            ||
Frog   435 YT 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IRSp53	NP_729679.2	I-BAR_IMD	4..222	CDD:153289	82/222 (37%)
IRSp53	NP_729679.2	SH3_Irsp53_BAIAP2L	364..419	CDD:212713	24/57 (42%)
LOC100485322	XP_002935048.2	I-BAR_IMD_IRSp53	3..234	CDD:153330	82/229 (36%)
		Herpes_BLLF1	<257..>496	CDD:282904	51/203 (25%)
		SH3	382..439	CDD:388381	24/56 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I4303
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H138365
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002273
OrthoInspector	1	1.000	-	-		otm49498
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1500
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.910