DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NaPi-III and SLC20A2

DIOPT Version :9

Sequence 1:	NP_001261704.1	Gene:	NaPi-III / 39255	FlyBaseID:	FBgn0260795	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_001244109.1	Gene:	SLC20A2 / 6575	HGNCID:	10947	Length:	652	Species:	Homo sapiens

Alignment Length:	706	Identity:	289/706 - (40%)
Similarity:	408/706 - (57%)	Gaps:	122/706 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ELLWMVVIGFLIAFVLAFGIGANDVANSFGTSVGSGVLTIRQACVLATICEISGAVLIGYKVSDT 71
            |.||||::||:|||:|||.:|||||||||||:|||||:|:||||:||:|.|.:|:||:|.||.:|
Human     5 EYLWMVILGFIIAFILAFSVGANDVANSFGTAVGSGVVTLRQACILASIFETTGSVLLGAKVGET 69

  Fly    72 MRKGILEVGLYEGAEEVLMLGCVAALASSAVWLLVATFLKLPISGTHSIVGSTIGFSLVARGVQG 136
            :||||::|.||....|.||.|.|:|:..||||.|:|:||:|||||||.||||||||||||.|.:|
Human    70 IRKGIIDVNLYNETVETLMAGEVSAMVGSAVWQLIASFLRLPISGTHCIVGSTIGFSLVAIGTKG 134

  Fly   137 LKWSTLGTIVGSWFISPVLSGIVSILLFLAIRRFILRAQEPLKAGFRSLPIFYGVTFFINVISVV 201
            ::|..|..||.||||||:|||.:|.|||:.||.|||:.::|:..|.|:||:||..|..|||.|::
Human   135 VQWMELVKIVASWFISPLLSGFMSGLLFVLIRIFILKKEDPVPNGLRALPVFYAATIAINVFSIM 199

  Fly   202 LDGPKLLYMDNIPTWIALTASFGLSLLVALLTQLVVVPLQRRKIAKRLRAENPVKFNFEDSVES- 265
            ..|..:|.: .:|.|.....|||::||.|....|.|.|..||||..:|:.|..:....::|:..
Human   200 YTGAPVLGL-VLPMWAIALISFGVALLFAFFVWLFVCPWMRRKITGKLQKEGALSRVSDESLSKV 263

  Fly   266 SPSGSPKKQRRPLSLVSEGKPLPAIAEITELVSLSDNS-----PRTFKLAPFGLAAK-------- 317
            ..:.||..:..|.:..::...:|......|.:..|:.:     ||    |.:|.|..
Human   264 QEAESPVFKELPGAKANDDSTIPLTGAAGETLGTSEGTSAGSHPR----AAYGRALSMTHGSVKS 324

  Fly   318 --NNNALGEE-------------YKIDPQLIKKAEDLLGKASLDNTDLTITSLNFIDEQQQQQQQ 367
              :|...|.:             :| |..|.|   |||.|..:|.            ..:::..|
Human   325 PISNGTFGFDGHTRSDGHVYHTVHK-DSGLYK---DLLHKIHIDR------------GPEEKPAQ 373

  Fly   368 QQNGRKLQE-----CFKR---------------MQSPKEEQKSKTNSIGTD---LETGSTKATNN 409
            :.|.|.|:.     |:..               ..:|::.:|...:::...   |...|..:..|
Human   374 ESNYRLLRRNNSYTCYTAAICGLPVHATFRAADSSAPEDSEKLVGDTVSYSKKRLRYDSYSSYCN 438

  Fly   410 ---NLQVVESGGSLDLMISSTLS-PNSSKVPLIESKEALNEQEEELKRTTGGGRRTSGAEETPEI 470
               ..::....|.:::.::|.|: |:..:      ::...|::||              ::.||:
Human   439 AVAEAEIEAEEGGVEMKLASELADPDQPR------EDPAEEEKEE--------------KDAPEV 483

  Fly   471 SMLFSFLQILTATFGSFAHGGNDVSNAIGPLIALYMIYREGSVMQQAESPIYILIYGGIGISVGL 535
            .:||.|||:|||.||||||||||||||||||:||::||::|.|.|:|.:|:::|.|||:||..||
Human   484 HLLFHFLQVLTACFGSFAHGGNDVSNAIGPLVALWLIYKQGGVTQEAATPVWLLFYGGVGICTGL 548

  Fly   536 WLWGRRVIETIGNDLTKITSSTGFTIEVGAAITVLLASKIGLPISTTHCKVGSVVFVGHVSASGR 600
            |:||||||:|:|.|||.||.|:|||||:.:|.||::||.||||:|||||||||||.||.:    |
Human   549 WVWGRRVIQTMGKDLTPITPSSGFTIELASAFTVVIASNIGLPVSTTHCKVGSVVAVGWI----R 609

  Fly   601 KKKSQPNDQTDKETHNEVAPMDDGSVDWHLFRNIAYAWIVTVPVTALLSAGMMYVL 656
            .:|                     :|||.|||||..||.|||||..|.||.:|.:|
Human   610 SRK---------------------AVDWRLFRNIFVAWFVTVPVAGLFSAAVMALL 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NaPi-III	NP_001261704.1	PitA	8..>227	CDD:223383	127/218 (58%)
		PHO4	29..>151	CDD:279693	78/121 (64%)
		PitA	<473..659	CDD:223383	107/184 (58%)
		PHO4	<525..648	CDD:279693	66/122 (54%)
SLC20A2	NP_001244109.1	PitA	7..>224	CDD:223383	127/217 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	273..307		4/33 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	458..477		4/24 (17%)
		PHO4	<491..637	CDD:307510	99/170 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145612
Domainoid	1	1.000	441	1.000	Domainoid score	I551
eggNOG	1	0.900	-	-		E1_COG0306
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	473	1.000	Inparanoid score	I1511
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56462
OrthoDB	1	1.010	-	-		D277773at33208
OrthoFinder	1	1.000	-	-		FOG0001121
OrthoInspector	1	1.000	-	-		otm41958
orthoMCL	1	0.900	-	-		OOG6_100354
Panther	1	1.100	-	-	O	PTHR11101
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2227
SonicParanoid	1	1.000	-	-		X962
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800