Protein Alignment NaPi-III and SLC20A2

DIOPT Version :10

• Sequence 1: NP_648441.1
• Gene: NaPi-III / 39255
• FlyBaseID: FBgn0260795
• Length: 667
• Species: Drosophila melanogaster
• Sequence 2: NP_006740.1
• Gene: SLC20A2 / 6575
• HGNCID: 10947
• Length: 652
• Species: Homo sapiens
• Alignment Length: 706
• Identity: 289/706 - (40%)
• Similarity: 408/706 - (57%)
• Gaps: 122/706 - (17%)

  Fly     7 ELLWMVVIGFLIAFVLAFGIGANDVANSFGTSVGSGVLTIRQACVLATICEISGAVLIGYKVSDT 71
            |.||||::||:|||:|||.:|||||||||||:|||||:|:||||:||:|.|.:|:||:|.||.:|
Human     5 EYLWMVILGFIIAFILAFSVGANDVANSFGTAVGSGVVTLRQACILASIFETTGSVLLGAKVGET 69

  Fly    72 MRKGILEVGLYEGAEEVLMLGCVAALASSAVWLLVATFLKLPISGTHSIVGSTIGFSLVARGVQG 136
            :||||::|.||....|.||.|.|:|:..||||.|:|:||:|||||||.||||||||||||.|.:|
Human    70 IRKGIIDVNLYNETVETLMAGEVSAMVGSAVWQLIASFLRLPISGTHCIVGSTIGFSLVAIGTKG 134

  Fly   137 LKWSTLGTIVGSWFISPVLSGIVSILLFLAIRRFILRAQEPLKAGFRSLPIFYGVTFFINVISVV 201
            ::|..|..||.||||||:|||.:|.|||:.||.|||:.::|:..|.|:||:||..|..|||.|::
Human   135 VQWMELVKIVASWFISPLLSGFMSGLLFVLIRIFILKKEDPVPNGLRALPVFYAATIAINVFSIM 199

  Fly   202 LDGPKLLYMDNIPTWIALTASFGLSLLVALLTQLVVVPLQRRKIAKRLRAENPVKFNFEDSVES- 265
            ..|..:|.: .:|.|.....|||::||.|....|.|.|..||||..:|:.|..:....::|:..
Human   200 YTGAPVLGL-VLPMWAIALISFGVALLFAFFVWLFVCPWMRRKITGKLQKEGALSRVSDESLSKV 263

  Fly   266 SPSGSPKKQRRPLSLVSEGKPLPAIAEITELVSLSDNS-----PRTFKLAPFGLAAK-------- 317
            ..:.||..:..|.:..::...:|......|.:..|:.:     ||    |.:|.|..
Human   264 QEAESPVFKELPGAKANDDSTIPLTGAAGETLGTSEGTSAGSHPR----AAYGRALSMTHGSVKS 324

  Fly   318 --NNNALGEE-------------YKIDPQLIKKAEDLLGKASLDNTDLTITSLNFIDEQQQQQQQ 367
              :|...|.:             :| |..|.|   |||.|..:|.            ..:::..|
Human   325 PISNGTFGFDGHTRSDGHVYHTVHK-DSGLYK---DLLHKIHIDR------------GPEEKPAQ 373

  Fly   368 QQNGRKLQE-----CFKR---------------MQSPKEEQKSKTNSIGTD---LETGSTKATNN 409
            :.|.|.|:.     |:..               ..:|::.:|...:::...   |...|..:..|
Human   374 ESNYRLLRRNNSYTCYTAAICGLPVHATFRAADSSAPEDSEKLVGDTVSYSKKRLRYDSYSSYCN 438

  Fly   410 ---NLQVVESGGSLDLMISSTLS-PNSSKVPLIESKEALNEQEEELKRTTGGGRRTSGAEETPEI 470
               ..::....|.:::.::|.|: |:..:      ::...|::||              ::.||:
Human   439 AVAEAEIEAEEGGVEMKLASELADPDQPR------EDPAEEEKEE--------------KDAPEV 483

  Fly   471 SMLFSFLQILTATFGSFAHGGNDVSNAIGPLIALYMIYREGSVMQQAESPIYILIYGGIGISVGL 535
            .:||.|||:|||.||||||||||||||||||:||::||::|.|.|:|.:|:::|.|||:||..||
Human   484 HLLFHFLQVLTACFGSFAHGGNDVSNAIGPLVALWLIYKQGGVTQEAATPVWLLFYGGVGICTGL 548

  Fly   536 WLWGRRVIETIGNDLTKITSSTGFTIEVGAAITVLLASKIGLPISTTHCKVGSVVFVGHVSASGR 600
            |:||||||:|:|.|||.||.|:|||||:.:|.||::||.||||:|||||||||||.||.:    |
Human   549 WVWGRRVIQTMGKDLTPITPSSGFTIELASAFTVVIASNIGLPVSTTHCKVGSVVAVGWI----R 609

  Fly   601 KKKSQPNDQTDKETHNEVAPMDDGSVDWHLFRNIAYAWIVTVPVTALLSAGMMYVL 656
            .:|                     :|||.|||||..||.|||||..|.||.:|.:|
Human   610 SRK---------------------AVDWRLFRNIFVAWFVTVPVAGLFSAAVMALL 644

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaPi-III	NP_648441.1	PHO4	27..>197	CDD:460184	105/169 (62%)
		PHO4	<464..649	CDD:460184	105/184 (57%)
SLC20A2	NP_006740.1	PHO4	25..>224	CDD:460184	115/199 (58%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	273..307		4/33 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	458..477		4/24 (17%)
		PHO4	<486..637	CDD:460184	103/175 (59%)