Protein Alignment NaPi-III and SLC20A1

DIOPT Version :10

• Sequence 1: NP_648441.1
• Gene: NaPi-III / 39255
• FlyBaseID: FBgn0260795
• Length: 667
• Species: Drosophila melanogaster
• Sequence 2: NP_005406.3
• Gene: SLC20A1 / 6574
• HGNCID: 10946
• Length: 679
• Species: Homo sapiens
• Alignment Length: 703
• Identity: 294/703 - (41%)
• Similarity: 410/703 - (58%)
• Gaps: 99/703 - (14%)

  Fly     7 ELLWMVVIGFLIAFVLAFGIGANDVANSFGTSVGSGVLTIRQACVLATICEISGAVLIGYKVSDT 71
            :.|||:::||:|||||||.:|||||||||||:|||||:|::|||:||:|.|..|:||:|.|||:|
Human    20 DYLWMLILGFIIAFVLAFSVGANDVANSFGTAVGSGVVTLKQACILASIFETVGSVLLGAKVSET 84

  Fly    72 MRKGILEVGLYEGAEEVLMLGCVAALASSAVWLLVATFLKLPISGTHSIVGSTIGFSLVARGVQG 136
            :|||:::|.:|...:.:||.|.|:|:..||||.|||:||||||||||.|||:||||||||:|.:|
Human    85 IRKGLIDVEMYNSTQGLLMAGSVSAMFGSAVWQLVASFLKLPISGTHCIVGATIGFSLVAKGQEG 149

  Fly   137 LKWSTLGTIVGSWFISPVLSGIVSILLFLAIRRFILRAQEPLKAGFRSLPIFYGVTFFINVISVV 201
            :|||.|..||.|||:||:||||:|.:||..:|.|||...:|:..|.|:||:||..|..||:.|::
Human   150 VKWSELIKIVMSWFVSPLLSGIMSGILFFLVRAFILHKADPVPNGLRALPVFYACTVGINLFSIM 214

  Fly   202 LDGPKLLYMDNIPTWIALTASFGLSLLVALLTQLVVVPLQRRKIAKRLR---AENPV--KFNF-- 259
            ..|..||..|.:|.|..:..|.|.::..||:....|.|..:|||.:.::   :|:|:  |.|.
Human   215 YTGAPLLGFDKLPLWGTILISVGCAVFCALIVWFFVCPRMKRKIEREIKCSPSESPLMEKKNSLK 279

  Fly   260 EDSVESSPSGSPKKQRRPLSLVSEGK-PLPAIAEITELVSLSDNSPRT--FKLAPFGLAAKNNNA 321
            ||..|:..|....:.:.|:|.|.... ||.|:.|           .||  |||.....|.:....
Human   280 EDHEETKLSVGDIENKHPVSEVGPATVPLQAVVE-----------ERTVSFKLGDLEEAPERERL 333

  Fly   322 ----LGEEYKIDPQLIKKAEDLLGKASLDNTDLTITS------LNFIDEQQQQQQQQQNG----- 371
                |.||..||       ..:.|...|.|.:|...|      :|.....|.....:.:|
Human   334 PSVDLKEETSID-------STVNGAVQLPNGNLVQFSQAVSNQINSSGHYQYHTVHKDSGLYKEL 391

  Fly   372 ------RKLQECFKRMQSPKEEQKSKTNS--------IGTDLETGSTKATNNNLQVVE--SGGSL 420
                  .|:.:|   |....::...:.||        .|..|::...|......:.:|  :..:.
Human   392 LHKLHLAKVGDC---MGDSGDKPLRRNNSYTSYTMAICGMPLDSFRAKEGEQKGEEMEKLTWPNA 453

  Fly   421 DLMISSTLSPNSSKVPLIESKEALNEQEEELKRTTGGGRR--TSGA------EETPEISMLFSFL 477
            |......:...:|....:....:.:|.:..:|...|.|.|  ::|:      ::.||:|:||.||
Human   454 DSKKRIRMDSYTSYCNAVSDLHSASEIDMSVKAEMGLGDRKGSNGSLEEWYDQDKPEVSLLFQFL 518

  Fly   478 QILTATFGSFAHGGNDVSNAIGPLIALYMIYREGSVMQQAESPIYILIYGGIGISVGLWLWGRRV 542
            |||||.||||||||||||||||||:|||::|..|.|..:..:||::|:|||:||.||||:|||||
Human   519 QILTACFGSFAHGGNDVSNAIGPLVALYLVYDTGDVSSKVATPIWLLLYGGVGICVGLWVWGRRV 583

  Fly   543 IETIGNDLTKITSSTGFTIEVGAAITVLLASKIGLPISTTHCKVGSVVFVGHVSASGRKKKSQPN 607
            |:|:|.|||.||.|:||:||:.:|:||::||.||||||||||||||||.||.:    |.||
Human   584 IQTMGKDLTPITPSSGFSIELASALTVVIASNIGLPISTTHCKVGSVVSVGWL----RSKK---- 640

  Fly   608 DQTDKETHNEVAPMDDGSVDWHLFRNIAYAWIVTVPVTALLSAGMM----YVL 656
                             :|||.|||||..||.||||::.::||.:|    ||:
Human   641 -----------------AVDWRLFRNIFMAWFVTVPISGVISAAIMAIFRYVI 676

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaPi-III	NP_648441.1	PHO4	27..>197	CDD:460184	103/169 (61%)
		PHO4	<464..649	CDD:460184	106/190 (56%)
SLC20A1	NP_005406.3	PHO4	40..>241	CDD:460184	113/200 (57%)
		PHO4	<503..665	CDD:460184	106/186 (57%)
		A	550..558		2/7 (29%)