DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NaPi-III and slc20a1

DIOPT Version :9

Sequence 1:	NP_001261704.1	Gene:	NaPi-III / 39255	FlyBaseID:	FBgn0260795	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_001025568.1	Gene:	slc20a1 / 594956	XenbaseID:	XB-GENE-482940	Length:	685	Species:	Xenopus tropicalis

Alignment Length:	712	Identity:	302/712 - (42%)
Similarity:	405/712 - (56%)	Gaps:	113/712 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MESFAPELLWMVVIGFLIAFVLAFGIGANDVANSFGTSVGSGVLTIRQACVLATICEISGAVLIG 65
            ||.|    |||:|:||:|||||||.:|||||||||||:|||||:|:||||:||:|.|..|:||:|
Frog    22 MEPF----LWMLVLGFVIAFVLAFSVGANDVANSFGTAVGSGVVTLRQACILASIFETVGSVLLG 82

  Fly    66 YKVSDTMRKGILEVGLYEGAEEVLMLGCVAALASSAVWLLVATFLKLPISGTHSIVGSTIGFSLV 130
            .|||:|:|||:::|..|...:|:||.|.::|:..||||.|.|:||||||||||.|||:|||||||
Frog    83 AKVSETIRKGLIDVNTYNTTQELLMAGSISAMFGSAVWQLAASFLKLPISGTHCIVGATIGFSLV 147

  Fly   131 ARGVQGLKWSTLGTIVGSWFISPVLSGIVSILLFLAIRRFILRAQEPLKAGFRSLPIFYGVTFFI 195
            |:|.|.::|..|..||.||||||:||||:|.|||..:|.||||..:|:..|.|:|||||..|..:
Frog   148 AKGQQAIQWYELLRIVLSWFISPLLSGIMSALLFYFVRMFILRKADPVPNGLRALPIFYACTIGV 212

  Fly   196 NVISVVLDGPKLLYMDNIPTWIALTASFGLSLLVALLTQLVVVPLQRRKIAKRLRAENPVKFNFE 260
            |:.|::..|..||..|.||.|..:..|.|.::|.||:....|.|..:|||              |
Frog   213 NLFSIMYSGAPLLGFDKIPLWGIILISVGCAVLCALVVWFFVCPRMKRKI--------------E 263

  Fly   261 DSVESSPSGSP---KKQRRPLSLVSEGKP----LPA----IAE----ITELVSLSDNSPR--TFK 308
            ...:||||.||   ||.|.....:.:..|    ||.    :||    |.::||:|....|  |||
Frog   264 CEFKSSPSESPLMDKKNRELRCPILKPDPEDIKLPVDGGIVAEVKVPILDMVSVSRTEERTVTFK 328

  Fly   309 LAPFGLAAKNNNALGEEYKIDPQLIKKAEDLLGKASLDN------TDLTITSLNFIDEQQQQQQQ 367
            :.....|.:.......|..||       :.:.|...|.|      :......:|...:.|.....
Frog   329 MGDCDDAVEKEKLNSMETNID-------QPMNGSVQLPNGNHVQFSQTVSNQMNSSGQYQYHTVH 386

  Fly   368 QQNG-----------RKLQECFKRMQSPKEEQKSKTNSI----------------GTDLETGSTK 405
            :.:|           .|:.:|   |....::...:.||.                ..|.|....:
Frog   387 KDSGLYKDLLHKLHLAKVGDC---MGDSGDKPLRRNNSYTSYTMAICGMPLDSLRNRDAEARPDE 448

  Fly   406 ATNNNLQVVESGGSLDLMISSTLSPNSSKVPLIESKEALNEQEEELKRTTGGGRRTSGA------ 464
            |....:...: |.....|.|.|...|:...|.::.:  ..||||.........|::|.:
Frog   449 AEKFTVHGAD-GKKRIRMDSYTSYCNAVADPQMDVE--AEEQEEGSIEDVATDRKSSSSSLEERH 510

  Fly   465 -EETPEISMLFSFLQILTATFGSFAHGGNDVSNAIGPLIALYMIYREGSVMQQAESPIYILIYGG 528
             ::.||:|:||.|||||||.||||||||||||||||||:|||::|..|.|..:|.:||::|:|||
Frog   511 DQDKPEVSLLFQFLQILTACFGSFAHGGNDVSNAIGPLVALYLVYESGDVTTKAATPIWLLLYGG 575

  Fly   529 IGISVGLWLWGRRVIETIGNDLTKITSSTGFTIEVGAAITVLLASKIGLPISTTHCKVGSVVFVG 593
            :||.:|||:||||||:|:|.|||.||.|:||:||:.:|:||::||.:|||||||||||||||.||
Frog   576 VGICIGLWVWGRRVIQTMGKDLTPITPSSGFSIELASALTVVIASNVGLPISTTHCKVGSVVSVG 640

  Fly   594 HVSASGRKKKSQPNDQTDKETHNEVAPMDDGSVDWHLFRNIAYAWIVTVPVTALLSAGMMYV 655
            .:    |.||                     :|||.|||||..||.||||::.|:||.:|.|
Frog   641 WL----RSKK---------------------AVDWRLFRNIFLAWFVTVPISGLISAAIMAV 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NaPi-III	NP_001261704.1	PitA	8..>227	CDD:223383	128/218 (59%)
		PHO4	29..>151	CDD:279693	76/121 (63%)
		PitA	<473..659	CDD:223383	107/183 (58%)
		PHO4	<525..648	CDD:279693	65/122 (53%)
slc20a1	NP_001025568.1	PHO4	44..>251	CDD:376541	118/206 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	482..513		6/32 (19%)
		PHO4	<498..671	CDD:376541	108/197 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	448	1.000	Domainoid score	I517
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	487	1.000	Inparanoid score	I1404
OMA	1	1.010	-	-		QHG56462
OrthoDB	1	1.010	-	-		D277773at33208
OrthoFinder	1	1.000	-	-		FOG0001121
OrthoInspector	1	1.000	-	-		otm49183
Panther	1	1.100	-	-	LDO	PTHR11101
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2227
SonicParanoid	1	1.000	-	-		X962
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110