DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NaPi-III and slc20a2

DIOPT Version :9

Sequence 1:	NP_001261704.1	Gene:	NaPi-III / 39255	FlyBaseID:	FBgn0260795	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	XP_005167225.1	Gene:	slc20a2 / 558346	ZFINID:	ZDB-GENE-060929-828	Length:	662	Species:	Danio rerio

Alignment Length:	711	Identity:	296/711 - (41%)
Similarity:	407/711 - (57%)	Gaps:	120/711 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MESFAPELLWMVVIGFLIAFVLAFGIGANDVANSFGTSVGSGVLTIRQACVLATICEISGAVLIG 65
            :||:    ||||||||:|||:|||.:|||||||||||:|||||:|:||||:||:|.|..|::|:|
Zfish     3 LESY----LWMVVIGFIIAFILAFSVGANDVANSFGTAVGSGVVTLRQACILASIFETLGSMLLG 63

  Fly    66 YKVSDTMRKGILEVGLYEGAEEVLMLGCVAALASSAVWLLVATFLKLPISGTHSIVGSTIGFSLV 130
            .||.:|:||||::|.||.....:||.|.|:|:..||||.|:|:||||||||||.|||||||||:|
Zfish    64 AKVGETIRKGIIDVSLYNDTVPILMAGEVSAMVGSAVWQLIASFLKLPISGTHCIVGSTIGFSMV 128

  Fly   131 ARGVQGLKWSTLGTIVGSWFISPVLSGIVSILLFLAIRRFILRAQEPLKAGFRSLPIFYGVTFFI 195
            |.|.:|::|..|..||.||||||:|||::|.|||..||.|||...:|:..|.|:||:||..|..|
Zfish   129 AIGTKGVQWMQLVKIVSSWFISPLLSGLMSGLLFFVIRYFILSKDDPVPNGLRALPLFYASTIGI 193

  Fly   196 NVISVVLDGPKLLYMDNIPTW-IALTASFGLSLLVALLTQLVVVPLQRRKIAKRLRAENPVKFNF 259
            |..|::..|..||.::.:|.| |||....| :|:.|.|..:.|.|..|||||.||:.|:.:....
Zfish   194 NTFSIMYTGAPLLGLEMLPVWAIALITLAG-ALVCAGLVWIFVCPWMRRKIASRLKKEHALSRIS 257

  Fly   260 EDSVESSP---SGSPKKQRRPLSLVSEGKPLPAIAEIT-ELVSLSDNSPRTFKLAPFGLAAKNNN 320
            ::|::..|   ..:|..:..|.:..|....||...|.| ||.||::..    .:.|.|......|
Zfish   258 DESLDKIPEEEEEAPVFKELPGAKSSNDAVLPMTEESTGELNSLANGG----TVLPNGRVYGRTN 318

  Fly   321 AL-----------------------GEEYKI---DPQLIKKAEDLLGKASLDNTDLTITSLNFID 359
            ::                       |:.|..   |..|.|   |||.|.....          ::
Zfish   319 SMTNGCLKSPVSNGGFSFDGHMRSDGQVYHTVHKDSGLYK---DLLHKIHKGR----------LE 370

  Fly   360 EQQQQQQQQQNGRKLQE-----CFK------------RMQS----PKEEQKSKTNSI---GTDLE 400
            :::...:...|.|.|:.     |:.            |.:|    |::.:|...:::   ...|.
Zfish   371 DERHGSRPDNNYRHLRRNNSYTCYTAAICGMPVQPLLRSESSAPPPEDSEKLVGDTVFYSKKRLR 435

  Fly   401 TGSTKATNN---NLQVVESGGSLDLMISSTLSPNSSKVPLIESKEALNEQEEELKRTTGGGRRTS 462
            ..|..:..|   ..::....|.:|:.:::     ..:.|.:.::..|.:..:|.|
Zfish   436 YDSYSSYCNAVAEAEIEAEEGDVDVNLAA-----DKREPRVPAEGVLEDCVDEDK---------- 485

  Fly   463 GAEETPEISMLFSFLQILTATFGSFAHGGNDVSNAIGPLIALYMIYREGSVMQQAESPIYILIYG 527
            ..::..::.:||.|||||||.||||||||||||||||||:||:|||.:|.|||.|.:|:::|.||
Zfish   486 AEKDNSQVFLLFHFLQILTACFGSFAHGGNDVSNAIGPLVALWMIYDQGGVMQDAATPVWLLFYG 550

  Fly   528 GIGISVGLWLWGRRVIETIGNDLTKITSSTGFTIEVGAAITVLLASKIGLPISTTHCKVGSVVFV 592
            |:||..|||:||||||:|:|.|||.||.|:|||||:.:|:||:|||.||||||||||||||||.|
Zfish   551 GVGICAGLWVWGRRVIQTMGKDLTPITPSSGFTIELASAVTVVLASNIGLPISTTHCKVGSVVAV 615

  Fly   593 GHVSASGRKKKSQPNDQTDKETHNEVAPMDDGSVDWHLFRNIAYAWIVTVPVTALLSAGMM 653
            |.:    |.:|                     :|||.|||||..||.|||||..|.||.:|
Zfish   616 GWI----RSRK---------------------AVDWRLFRNIFLAWFVTVPVAGLFSAAVM 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NaPi-III	NP_001261704.1	PitA	8..>227	CDD:223383	128/219 (58%)
		PHO4	29..>151	CDD:279693	76/121 (63%)
		PitA	<473..659	CDD:223383	111/181 (61%)
		PHO4	<525..648	CDD:279693	68/122 (56%)
slc20a2	XP_005167225.1	PitA	7..>225	CDD:223383	128/218 (59%)
slc20a2	XP_005167225.1	PHO4	<501..647	CDD:307510	104/170 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579001
Domainoid	1	1.000	465	1.000	Domainoid score	I450
eggNOG	1	0.900	-	-		E1_COG0306
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	498	1.000	Inparanoid score	I1339
OMA	1	1.010	-	-		QHG56462
OrthoDB	1	1.010	-	-		D277773at33208
OrthoFinder	1	1.000	-	-		FOG0001121
OrthoInspector	1	1.000	-	-		otm25936
orthoMCL	1	0.900	-	-		OOG6_100354
Panther	1	1.100	-	-	O	PTHR11101
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2227
SonicParanoid	1	1.000	-	-		X962
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800