DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NaPi-III and slc20a2

DIOPT Version :9

Sequence 1:	NP_001261704.1	Gene:	NaPi-III / 39255	FlyBaseID:	FBgn0260795	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_001016904.1	Gene:	slc20a2 / 549658	XenbaseID:	XB-GENE-1015057	Length:	653	Species:	Xenopus tropicalis

Alignment Length:	700	Identity:	289/700 - (41%)
Similarity:	407/700 - (58%)	Gaps:	109/700 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ELLWMVVIGFLIAFVLAFGIGANDVANSFGTSVGSGVLTIRQACVLATICEISGAVLIGYKVSDT 71
            |.||||::||:|||:|||.:|||||||||||:|||||:|:||||:||:|.|.:|:||:|.||.:|
Frog     5 EYLWMVIVGFIIAFILAFSVGANDVANSFGTAVGSGVVTLRQACILASIFETTGSVLLGAKVGET 69

  Fly    72 MRKGILEVGLYEGAEEVLMLGCVAALASSAVWLLVATFLKLPISGTHSIVGSTIGFSLVARGVQG 136
            :||||::|.||....::||.|.|:|:..||||.|:|:||:|||||||.|||:||||||||.|..|
Frog    70 IRKGIIDVNLYNNTVDLLMAGEVSAMVGSAVWQLIASFLRLPISGTHCIVGATIGFSLVAIGTHG 134

  Fly   137 LKWSTLGTIVGSWFISPVLSGIVSILLFLAIRRFILRAQEPLKAGFRSLPIFYGVTFFINVISVV 201
            ::|..|..||.||||||:|||::|..|||.|:.|||:.::|:..|.::||:||..|..|||.|::
Frog   135 VQWMQLVKIVASWFISPLLSGLMSGALFLMIKFFILKKEDPVPNGLKALPVFYAATIGINVFSIL 199

  Fly   202 LDGPKLLYMDNIPTWIALTASFGLSLLVALLTQLVVVPLQRRKIAKRLRAENPVKFNFEDSVESS 266
            ..|..||.:::.|.|.....|.|::::.||:....|.|..::|||.||:.|..:....|:|::
Frog   200 YTGAPLLGLESFPVWATALLSIGIAIIFALIVWFFVCPWMKKKIASRLKKEGALSRISEESLD-- 262

  Fly   267 PSGSPKKQRRPLSLVSE--------GKPLPAIAEITELVSLSDNSPRTFKLAPFGLAAKNNNA-- 321
                 |.|....|:..|        ...||..:..|:....||:........|:|.||...|.
Frog   263 -----KIQDEETSVFKELPGAKGNDESALPLTSSSTDAAVASDSVSNGNTRVPYGRAASMTNGSI 322

  Fly   322 ----LGEEYKIDPQLIKK--------------AEDLLGKASLD--NTDLTITSLNFIDEQQQQQQ 366
                ....:..|...:|.              .:|||....||  .||......|:      :..
Frog   323 RSPISNGTFNFDGHTVKSDVHVYHTVHKDSGLYKDLLHNIHLDRVKTDRPAPENNY------RVL 381

  Fly   367 QQQN----------GRKLQECFKR--MQSPKEEQKSKTNSIGTDLETGSTKATNNNLQVV----- 414
            ::.|          |..:...||.  :..|::.:|...:::....:.....:.::....|
Frog   382 RRNNSYTCYTAAICGVPVHSTFKSSDVAMPEDSEKLVGDTVSYSKKRVRYDSYSSYCNAVAEAEI 446

  Fly   415 --ESGGSLDLMISSTLS-PNSSKVPLIESKEALNEQEEELKRTTGGGRRTSGAEETPEISMLFSF 476
              |.|| :::.:::.|: ||..:      .::|.|.:||              ::..|:.:||.|
Frog   447 EAEEGG-VEMKLATDLADPNPPQ------DDSLEEDKEE--------------KDKSEVHLLFHF 490

  Fly   477 LQILTATFGSFAHGGNDVSNAIGPLIALYMIYREGSVMQQAESPIYILIYGGIGISVGLWLWGRR 541
            ||||||.||||||||||||||||||:||::||.:|.|||:|.:|:::|:|||:||..|||:||||
Frog   491 LQILTACFGSFAHGGNDVSNAIGPLVALWLIYEQGGVMQEASTPVWLLLYGGVGICAGLWVWGRR 555

  Fly   542 VIETIGNDLTKITSSTGFTIEVGAAITVLLASKIGLPISTTHCKVGSVVFVGHVSASGRKKKSQP 606
            ||:|:|.|||.||.|:|||||:.:|.||::||.||||||||||||||||.||.:    |.:|
Frog   556 VIQTMGKDLTPITPSSGFTIELASAFTVVVASNIGLPISTTHCKVGSVVAVGWI----RSRK--- 613

  Fly   607 NDQTDKETHNEVAPMDDGSVDWHLFRNIAYAWIVTVPVTALLSAGMMYVL 656
                              :|||.|||||..||.|||||..|.|||:|.:|
Frog   614 ------------------AVDWRLFRNIFLAWFVTVPVAGLFSAGVMAIL 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NaPi-III	NP_001261704.1	PitA	8..>227	CDD:223383	123/218 (56%)
		PHO4	29..>151	CDD:279693	76/121 (63%)
		PitA	<473..659	CDD:223383	110/183 (60%)
		PHO4	<525..648	CDD:279693	67/122 (55%)
slc20a2	NP_001016904.1	PHO4	25..>225	CDD:396107	111/199 (56%)
slc20a2	NP_001016904.1	PHO4	<478..638	CDD:396107	108/198 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	448	1.000	Domainoid score	I517
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	487	1.000	Inparanoid score	I1404
OMA	1	1.010	-	-		QHG56462
OrthoDB	1	1.010	-	-		D277773at33208
OrthoFinder	1	1.000	-	-		FOG0001121
OrthoInspector	1	1.000	-	-		otm49183
Panther	1	1.100	-	-	O	PTHR11101
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2227
SonicParanoid	1	1.000	-	-		X962
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.110