DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NaPi-III and slc20a1a

DIOPT Version :9

Sequence 1:	NP_001261704.1	Gene:	NaPi-III / 39255	FlyBaseID:	FBgn0260795	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_998344.1	Gene:	slc20a1a / 406458	ZFINID:	ZDB-GENE-040426-2217	Length:	652	Species:	Danio rerio

Alignment Length:	696	Identity:	294/696 - (42%)
Similarity:	394/696 - (56%)	Gaps:	118/696 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ELLWMVVIGFLIAFVLAFGIGANDVANSFGTSVGSGVLTIRQACVLATICEISGAVLIGYKVSDT 71
            ::||::::||:|||:|||.:|||||||||||:|||||:|:||||:||||.|..||:|:|.|||:|
Zfish    25 DVLWLLILGFVIAFILAFSVGANDVANSFGTAVGSGVVTLRQACILATIFETVGAMLLGAKVSET 89

  Fly    72 MRKGILEVGLYEGAEEVLMLGCVAALASSAVWLLVATFLKLPISGTHSIVGSTIGFSLVARGVQG 136
            :|.||::|.:|.|:|.|||.|.::|:..||||.|.|:||||||||||.|||:|||||:||||.||
Zfish    90 IRSGIIDVHMYNGSEAVLMAGSISAMFGSAVWQLAASFLKLPISGTHCIVGATIGFSMVARGHQG 154

  Fly   137 LKWSTLGTIVGSWFISPVLSGIVSILLFLAIRRFILRAQEPLKAGFRSLPIFYGVTFFINVISVV 201
            :||..|..||.|||:||:||||:|.:||..:|:|||...:|:..|.|:||:||.||..||:.|::
Zfish   155 VKWLELLRIVASWFLSPLLSGIMSAVLFYFVRKFILNKDDPVPNGLRALPVFYAVTMGINLFSIM 219

  Fly   202 LDGPKLLYMDNIPTWIALTASFGLSLLVALLTQLVVVPLQRRKIAKRLRAENPVKFNFEDSVESS 266
            ..|..:|..|.||.|..|..|.|.::|.||:...:|.|..::|:..:....|....:....||..
Zfish   220 FTGAPMLGFDRIPWWGTLLISLGCAILTALVVWFIVCPRLKKKMQSKCLGPNIADTSGTQLVEKK 284

  Fly   267 PSGSPKKQRRPLSLVSEGKPLPAIAEITELVSLSDNSPRTFKLAPFGLAAKNNNALGEEYKIDPQ 331
            ||.:......|                        ..||.:...|....|.:|       |:...
Zfish   285 PSSNGLMDHHP------------------------GPPRNYSPVPQTPPADSN-------KVAFD 318

  Fly   332 LIKKAEDLLGKASLDNTDLTIT-SLN--------FIDEQQQQQQQQQNG-----------RKLQE 376
            :...||..|.|...|..|...| :||        .:...|.....:.:|           .|:.|
Zfish   319 IGGSAETDLDKKEFDTKDQDCTHALNGSGGIVIPDLSGNQFHTVHKDSGIYKDLLHKLHLAKVGE 383

  Fly   377 CFKRMQSPKEEQKSKTNSIGTDLETGSTKA---TNNNLQVVESGGSLDL----MISSTLSPNSSK 434
            |   :..|.|:...:.||.     |..|.|   .:.:|:..|.|....|    ..|...|.||..
Zfish   384 C---IGEPVEKPIRRNNSY-----TSYTMAIYGIHGSLKDGEGGSRTGLDGEKRRSRYDSYNSYC 440

  Fly   435 VPLIESKEALNE-------QEEELKRTTGGGRRTSGAEE--------TPEISMLFSFLQILTATF 484
            ..:.:.:.||.:       ::|.|        |....||        .||:|.||.|||||||.|
Zfish   441 TAVADGEAALEDAALAVGMEDEAL--------REDVLEEDIDELEIDKPEVSTLFQFLQILTACF 497

  Fly   485 GSFAHGGNDVSNAIGPLIALYMIYREGSVMQQAESPIYILIYGGIGISVGLWLWGRRVIETIGND 549
            |||||||||||||||||:||::||...||...|.:||::|:|||:||..|||:||||||:|:|.|
Zfish   498 GSFAHGGNDVSNAIGPLVALWLIYDSASVAPSAPTPIWLLLYGGVGICTGLWIWGRRVIQTMGKD 562

  Fly   550 LTKITSSTGFTIEVGAAITVLLASKIGLPISTTHCKVGSVVFVGHVSASGRKKKSQPNDQTDKET 614
            ||.||.|:||:||:.:||||::||.||||:|||||||||||.||.:    |.:|
Zfish   563 LTPITPSSGFSIELASAITVVVASNIGLPVSTTHCKVGSVVSVGWL----RSRK----------- 612

  Fly   615 HNEVAPMDDGSVDWHLFRNIAYAWIVTVPVTALLSAGMM----YVL 656
                      :|||||||||..||.||||::.|:||.:|    ||:
Zfish   613 ----------AVDWHLFRNIFIAWFVTVPISGLISAAIMALFYYVI 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NaPi-III	NP_001261704.1	PitA	8..>227	CDD:223383	128/218 (59%)
		PHO4	29..>151	CDD:279693	81/121 (67%)
		PitA	<473..659	CDD:223383	109/188 (58%)
		PHO4	<525..648	CDD:279693	66/122 (54%)
slc20a1a	NP_998344.1	PitA	27..>255	CDD:223383	131/227 (58%)
		PHO4	47..>149	CDD:279693	68/101 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	278..308		8/53 (15%)
		PitA	<479..644	CDD:223383	110/189 (58%)
		PHO4	<538..636	CDD:279693	66/122 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579000
Domainoid	1	1.000	465	1.000	Domainoid score	I450
eggNOG	1	0.900	-	-		E1_COG0306
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H138209
Inparanoid	1	1.050	498	1.000	Inparanoid score	I1339
OMA	1	1.010	-	-		QHG56462
OrthoDB	1	1.010	-	-		D277773at33208
OrthoFinder	1	1.000	-	-		FOG0001121
OrthoInspector	1	1.000	-	-		otm25936
orthoMCL	1	0.900	-	-		OOG6_100354
Panther	1	1.100	-	-	O	PTHR11101
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X962
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770