DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NaPi-III and slc20a1b

DIOPT Version :9

Sequence 1:	NP_001261704.1	Gene:	NaPi-III / 39255	FlyBaseID:	FBgn0260795	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_997753.1	Gene:	slc20a1b / 321541	ZFINID:	ZDB-GENE-030131-260	Length:	665	Species:	Danio rerio

Alignment Length:	723	Identity:	297/723 - (41%)
Similarity:	405/723 - (56%)	Gaps:	156/723 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ELLWMVVIGFLIAFVLAFGIGANDVANSFGTSVGSGVLTIRQACVLATICEISGAVLIGYKVSDT 71
            :.:|::::||:|||||||.:|||||||||||:|||||:|:||||:||:|.|..|:||:|.|||:|
Zfish    25 DYMWLLIVGFIIAFVLAFSVGANDVANSFGTAVGSGVVTLRQACILASIFETLGSVLLGAKVSET 89

  Fly    72 MRKGILEVGLYEGAEEVLMLGCVAALASSAVWLLVATFLKLPISGTHSIVGSTIGFSLVARGVQG 136
            :||||::|.:|:..|.|||.|.|:|:..||||.|.|:||||||||||.|||:||||||||:|.||
Zfish    90 IRKGIIDVTMYKDIEHVLMAGSVSAMFGSAVWQLAASFLKLPISGTHCIVGATIGFSLVAKGQQG 154

  Fly   137 LKWSTLGTIVGSWFISPVLSGIVSILLFLAIRRFILRAQEPLKAGFRSLPIFYGVTFFINVISVV 201
            :||..|..||.|||:||:|||::|.:||..:|.|||:.::|:..|.|:||.||.||..||:.|::
Zfish   155 VKWLELLRIVASWFLSPLLSGVMSAVLFYFVRMFILQKKDPVPNGLRALPFFYAVTMGINLFSIM 219

  Fly   202 LDGPKLLYMDNIPTWIALTASFGLSLLVALLTQLVVVPLQRRKIAKRLRAENPVKFNFEDSVESS 266
            ..|..:|..|.:|.|..|..|.|..::.||:....|.|..::||      |..||       .||
Zfish   220 FTGAPMLGFDKLPWWGVLLISIGFGIITALIVWFAVCPRLKKKI------ECEVK-------SSS 271

  Fly   267 PSGSPKKQRRPLSLVSEG--KPLPAIAEITELVSLSDNSPRTFKLAP------------------ 311
            ||.||..::|.|......  ||:|..:.:     ||.::|.|..|.|
Zfish   272 PSESPLMEKRELHEAHSPILKPVPEESSV-----LSSSTPTTPPLPPPEERRVTFDIGDSDDADQ 331

  Fly   312 -------FGLAAKN-------------NNALGEEYKI--DPQLIKKAEDLLGKASL--------- 345
                   .|.|.|.             :|...:.:.:  |..|.|   |||.|..|
Zfish   332 KDCKESDLGGAPKTAHVHFTNGPAHIPSNGYSQYHTVHKDSGLYK---DLLHKLHLAKVGDCMGE 393

  Fly   346 -------DNTDLTITSLNFIDEQQQQQQQQQNGRKLQECFKRMQSPKEEQKSKTNSI-------- 395
                   .|...|..::..|......:.::...|..::..|.....:|.::.:.:|.
Zfish   394 GGDRPIRRNNSYTSYTMAIIGMHGDFKPKESEFRASEDGDKEKAGAQERKRIRMDSYTSYCNAVA 458

  Fly   396 --GTDLETGSTKATNNNLQVV-ESGGSLDLMISSTLSPNSSKVPLIESKEALNEQEEELKRTTGG 457
              ||..:.|..:.|   |::| |..||                    |:.:|.|.
Zfish   459 ENGTPEDLGEGEVT---LEMVDEDAGS--------------------SRSSLEED---------- 490

  Fly   458 GRRTSGAEETPEISMLFSFLQILTATFGSFAHGGNDVSNAIGPLIALYMIYREGSVMQQAESPIY 522
              ||..  :.||:||||.|||||||.||||||||||||||||||:||:::|..|||:..|.:||:
Zfish   491 --RTDA--DKPEVSMLFQFLQILTACFGSFAHGGNDVSNAIGPLVALWLVYESGSVISSAPTPIW 551

  Fly   523 ILIYGGIGISVGLWLWGRRVIETIGNDLTKITSSTGFTIEVGAAITVLLASKIGLPISTTHCKVG 587
            :|:|||:||.||||:||||||:|:|.|||.||.|:||:||:.:|:||::||.||||:||||||||
Zfish   552 LLLYGGVGICVGLWVWGRRVIQTMGRDLTPITPSSGFSIELASAVTVVVASNIGLPVSTTHCKVG 616

  Fly   588 SVVFVGHVSASGRKKKSQPNDQTDKETHNEVAPMDDGSVDWHLFRNIAYAWIVTVPVTALLSAGM 652
            |||.||.:    |.:|                     :|||.|||||..||.||||::.|:||.:
Zfish   617 SVVAVGWL----RSRK---------------------AVDWRLFRNIFMAWFVTVPISGLISAAI 656

  Fly   653 M----YVL 656
            |    ||:
Zfish   657 MALFNYVI 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NaPi-III	NP_001261704.1	PitA	8..>227	CDD:223383	126/218 (58%)
		PHO4	29..>151	CDD:279693	81/121 (67%)
		PitA	<473..659	CDD:223383	108/188 (57%)
		PHO4	<525..648	CDD:279693	65/122 (53%)
slc20a1b	NP_997753.1	PitA	27..>252	CDD:223383	128/224 (57%)
		PHO4	47..>149	CDD:279693	69/101 (68%)
		Peptidase_U4	123..>268	CDD:302932	73/150 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	294..345		9/55 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	423..442		2/18 (11%)
		PitA	<495..664	CDD:223383	111/193 (58%)
		PHO4	<554..652	CDD:279693	65/122 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579002
Domainoid	1	1.000	465	1.000	Domainoid score	I450
eggNOG	1	0.900	-	-		E1_COG0306
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	498	1.000	Inparanoid score	I1339
OMA	1	1.010	-	-		QHG56462
OrthoDB	1	1.010	-	-		D277773at33208
OrthoFinder	1	1.000	-	-		FOG0001121
OrthoInspector	1	1.000	-	-		otm25936
orthoMCL	1	0.900	-	-		OOG6_100354
Panther	1	1.100	-	-	LDO	PTHR11101
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2227
SonicParanoid	1	1.000	-	-		X962
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800