DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NaPi-III and Slc20a2

DIOPT Version :9

Sequence 1:	NP_001261704.1	Gene:	NaPi-III / 39255	FlyBaseID:	FBgn0260795	Length:	667	Species:	Drosophila melanogaster
Sequence 2:	NP_058919.1	Gene:	Slc20a2 / 29502	RGDID:	3699	Length:	656	Species:	Rattus norvegicus

Alignment Length:	706	Identity:	293/706 - (41%)
Similarity:	407/706 - (57%)	Gaps:	119/706 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LWMVVIGFLIAFVLAFGIGANDVANSFGTSVGSGVLTIRQACVLATICEISGAVLIGYKVSDTMR 73
            ||||::||:|||:|||.:|||||||||||:|||||:|:||||:||:|.|.:|:||:|.||.:|:|
  Rat     7 LWMVILGFIIAFILAFSVGANDVANSFGTAVGSGVVTLRQACILASIFETTGSVLLGAKVGETIR 71

  Fly    74 KGILEVGLYEGAEEVLMLGCVAALASSAVWLLVATFLKLPISGTHSIVGSTIGFSLVARGVQGLK 138
            |||::|.||....|.||.|.|:|:..||||.|:|:||:|||||||.||||||||||||.|.:|::
  Rat    72 KGIIDVNLYNETVETLMAGEVSAMVGSAVWQLIASFLRLPISGTHCIVGSTIGFSLVAIGPKGVQ 136

  Fly   139 WSTLGTIVGSWFISPVLSGIVSILLFLAIRRFILRAQEPLKAGFRSLPIFYGVTFFINVISVVLD 203
            |..|..||.||||||:|||.:|.:||:.||.|||..::|:..|.::||:||..|..|||.|::..
  Rat   137 WMELVKIVASWFISPLLSGFMSGVLFILIRMFILTKEDPVPNGLQALPLFYAATIAINVFSIMYT 201

  Fly   204 GPKLLYMDNIPTWIALTASFGLSLLVALLTQLVVVPLQRRKIAKRLRAENPVKFNFEDSVES-SP 267
            |..:|.: ::|.|.....|||::||.|....|.|.|..:||||.||..|:.:....::|:.. ..
  Rat   202 GAPVLGL-SLPIWAIALISFGVALLFAFFVWLFVCPWMKRKIAGRLEKESALSRASDESLRKVQE 265

  Fly   268 SGSPKKQRRPLSLVSEGKPLPAIAEITELVSLSD-----NSPRTFKLAPFGLA-------AK--- 317
            :.||..:..|.:..|:...:|..:...|....|:     |.||    |.:|.|       ||
  Rat   266 AESPVFKELPGAKASDDSAVPLTSLAGEAAGASEGTSAGNHPR----ASYGRALSMTHGSAKSPI 326

  Fly   318 NNNALGEEYKI------------DPQLIKKAEDLLGKASLDNTDLTITSLNFIDEQQQQQQQQQN 370
            :|...|.|..:            |..|.|   |||.|..:|.            ..:::..|:.|
  Rat   327 SNGTFGFEGHMRNDGHVYHTVHKDSGLYK---DLLHKIHVDK------------GPEEKPAQENN 376

  Fly   371 GRKLQE-----CFKR----MQSPKEEQKSKTNSIGTDLE--TGSTKATNN--------------- 409
            .|.|:.     |:..    |......:.|.|:|...|.|  .|.|.:.:.
  Rat   377 YRLLRRNNSYTCYTAAICGMPVHATFRASDTSSAPEDSEKLVGDTVSYSKKRLRYDSYSSYCNAV 441

  Fly   410 -NLQVVESGGSLDLMISSTLSPNSSKVPLIESKEALNEQEEELKRTTGGGRRTSGAEETPEISML 473
             ..::....|.:::.::|.|:.     |....::...:::||              :::.|:.:|
  Rat   442 AEAEIEAEEGGVEMRLASELTD-----PDQPHEDPAEDEKEE--------------KDSAEVHLL 487

  Fly   474 FSFLQILTATFGSFAHGGNDVSNAIGPLIALYMIYREGSVMQQAESPIYILIYGGIGISVGLWLW 538
            |.|||:|||.||||||||||||||||||:||::||::|.|.|:|.:|:::|.|||:||..|||:|
  Rat   488 FHFLQVLTACFGSFAHGGNDVSNAIGPLVALWLIYKQGGVTQEAATPVWLLFYGGVGICTGLWVW 552

  Fly   539 GRRVIETIGNDLTKITSSTGFTIEVGAAITVLLASKIGLPISTTHCKVGSVVFVGHVSASGRKKK 603
            |||||:|:|.|||.||.|:|||||:.:|.||::||.||||:|||||||||||.||.:    |.:|
  Rat   553 GRRVIQTMGKDLTPITPSSGFTIELASAFTVVIASNIGLPVSTTHCKVGSVVAVGWI----RSRK 613

  Fly   604 SQPNDQTDKETHNEVAPMDDGSVDWHLFRNIAYAWIVTVPVTALLSAGMMYVLCAI 659
                                 :|||.|||||..||.|||||..|.||.:|.:|..|
  Rat   614 ---------------------AVDWRLFRNIFIAWFVTVPVAGLFSAAIMALLMYI 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NaPi-III	NP_001261704.1	PitA	8..>227	CDD:223383	125/217 (58%)
		PHO4	29..>151	CDD:279693	78/121 (64%)
		PitA	<473..659	CDD:223383	107/185 (58%)
		PHO4	<525..648	CDD:279693	66/122 (54%)
Slc20a2	NP_058919.1	PHO4	25..>224	CDD:396107	113/199 (57%)
Slc20a2	NP_058919.1	PHO4	<478..638	CDD:396107	105/198 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339304
Domainoid	1	1.000	442	1.000	Domainoid score	I518
eggNOG	1	0.900	-	-		E1_COG0306
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	475	1.000	Inparanoid score	I1432
OMA	1	1.010	-	-		QHG56462
OrthoDB	1	1.010	-	-		D277773at33208
OrthoFinder	1	1.000	-	-		FOG0001121
OrthoInspector	1	1.000	-	-		otm46098
orthoMCL	1	0.900	-	-		OOG6_100354
Panther	1	1.100	-	-	O	PTHR11101
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X962
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770