DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ufd1-like and UFD1

DIOPT Version :9

Sequence 1:	NP_524023.1	Gene:	Ufd1-like / 39254	FlyBaseID:	FBgn0036136	Length:	316	Species:	Drosophila melanogaster
Sequence 2:	NP_005650.2	Gene:	UFD1 / 7353	HGNCID:	12520	Length:	307	Species:	Homo sapiens

Alignment Length:	326	Identity:	185/326 - (56%)
Similarity:	221/326 - (67%)	Gaps:	30/326 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFHFSGFNMMFPE--GRNFHANYKCFSVSMLPG-NERTDVEKGGKIIMPPSALDTLTRLNVEYPM 62
            ||.|:.|:...|.  ...|...|:|||||||.| |:|:||||||||||||||||.|:|||:.|||
Human     1 MFSFNMFDHPIPRVFQNRFSTQYRCFSVSMLAGPNDRSDVEKGGKIIMPPSALDQLSRLNITYPM 65

  Fly    63 LFKLTNVKKSRSSHAGVLEFVADEGKCYLPHWMMENLLLGEGDILNIESVSLPVATFSKFQPHST 127
            ||||||....|.:|.||||||||||.||||||||:||||.||.::.:|||:|.|||:|||||.|.
Human    66 LFKLTNKNSDRMTHCGVLEFVADEGICYLPHWMMQNLLLEEGGLVQVESVNLQVATYSKFQPQSP 130

  Fly   128 DFLDITNPKAVLENALRNFACLTRGDVIAIKYNKKVYELCVLETKPGNAVSIIECDMNVEFEAPV 192
            |||||||||||||||||||||||.||||||.||:|:|||.|:||||..|||||||||||:|:||:
Human   131 DFLDITNPKAVLENALRNFACLTTGDVIAINYNEKIYELRVMETKPDKAVSIIECDMNVDFDAPL 195

  Fly   193 GYKD------HSETQASGSGQQGAAGTVGGEIAGATNAILEEVVETFKGSGVRLDGKKKKESQLE 251
            |||:      |.|:....:...|.||.:|              ...|.|||.|||||||......
Human   196 GYKEPERQVQHEESTEGEADHSGYAGELG--------------FRAFSGSGNRLDGKKKGVEPSP 246

  Fly   252 TPVVKKVLARGVPDYDFQFGLIRFDRNIRPISDRSQEDDAVAGNADASDAESFHGTGFSM-KKTR 315
            :|:....:.||:|:|:|:.|.|.|.||.||:..:.:||:| .|...|     |.|.|.|: ||.|
Human   247 SPIKPGDIKRGIPNYEFKLGKITFIRNSRPLVKKVEEDEA-GGRFVA-----FSGEGQSLRKKGR 305

  Fly   316 K 316
            |
Human   306 K 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ufd1-like	NP_524023.1	UFD1	4..316	CDD:227469	181/321 (56%)
Ufd1-like	NP_524023.1	UFD1	17..190	CDD:281187	132/173 (76%)
UFD1	NP_005650.2	UFD1	19..193	CDD:397321	132/173 (76%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	231..258		11/26 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	288..307		10/24 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140739
Domainoid	1	1.000	276	1.000	Domainoid score	I1754
eggNOG	1	0.900	-	-		E1_COG5140
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H39090
Inparanoid	1	1.050	337	1.000	Inparanoid score	I2399
Isobase	1	0.950	-	0	Normalized mean entropy	S1050
OMA	1	1.010	-	-		QHG53647
OrthoDB	1	1.010	-	-		D1134444at2759
OrthoFinder	1	1.000	-	-		FOG0003822
OrthoInspector	1	1.000	-	-		oto88877
orthoMCL	1	0.900	-	-		OOG6_101567
Panther	1	1.100	-	-	LDO	PTHR12555
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2330
SonicParanoid	1	1.000	-	-		X2666
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750