DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FoxK and FOXQ1

DIOPT Version :9

Sequence 1:	NP_001261701.1	Gene:	FoxK / 39252	FlyBaseID:	FBgn0036134	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_150285.3	Gene:	FOXQ1 / 94234	HGNCID:	20951	Length:	403	Species:	Homo sapiens

Alignment Length:	269	Identity:	76/269 - (28%)
Similarity:	115/269 - (42%)	Gaps:	67/269 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   365 APPAGAAAHLIAGD-------GPGIYSPLKISIPKKEQKSPYLSPTGTIS-AANSCPASPRQGFI 421
            :|.||..|....||       |||           .|:..|..:....:: .|.:..|.|..|
Human    50 SPAAGGGARDTQGDGEQSAGGGPG-----------AEEAIPAAAAAAVVAEGAEAGAAGPGAG-- 101

  Fly   422 QNQPNNYNNYGNNNTQDLFQTPSTASYNHNEKPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKH 486
                      |..:.:.....|    |....||||||..||..||..:...:|||:.|..:::..
Human   102 ----------GAGSGEGARSKP----YTRRPKPPYSYIALIAMAIRDSAGGRLTLAEINEYLMGK 152

  Fly   487 YPYYRKETNKGWQNSIRHNLSLNRYFIKVARSQDEP-GKGSFWRIDPDSGAKLIDHSYKKRRQRS 550
            :|::| .:..||:||:|||||||..|:||.|....| ||.::|.::|:|.....|..:::||:|.
Human   153 FPFFR-GSYTGWRNSVRHNLSLNDCFVKVLRDPSRPWGKDNYWMLNPNSEYTFADGVFRRRRKRL 216

  Fly   551 SQ-------GFRPPY--GMPRSAPVSPSHMDNSRESSPLQDIVLQSAPGSPGM---SLEQRAADP 603
            |.       |.||..  |:|.:.|.:|                  :||.||.|   :.::..|.|
Human   217 SHRAPVPAPGLRPEEAPGLPAAPPPAP------------------AAPASPRMRSPARQEERASP 263

  Fly   604 EIIYNSQNA 612
            ...::|..|
Human   264 AGKFSSSFA 272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FoxK	NP_001261701.1	FHA	<170..253	CDD:238017
FoxK	NP_001261701.1	Forkhead	453..540	CDD:278670	37/87 (43%)
FOXQ1	NP_150285.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..75		9/35 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	94..116		6/37 (16%)
		FH	119..197	CDD:238016	35/78 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	216..266		15/67 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820