DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FoxK and FHL1

DIOPT Version :9

Sequence 1:	NP_001261701.1	Gene:	FoxK / 39252	FlyBaseID:	FBgn0036134	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_015429.1	Gene:	FHL1 / 856219	SGDID:	S000006308	Length:	936	Species:	Saccharomyces cerevisiae

Alignment Length:	763	Identity:	153/763 - (20%)
Similarity:	263/763 - (34%)	Gaps:	206/763 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 NSSSTNNSSSNNNNSIASSHNNNNNI-----VTVHTVLNNP--------PTNTAG---GGVADAA 66
            ||:...:.:.:..|:|..:|:::..:     :.:..|  ||        ..|||.   .|:.::.
Yeast   119 NSNELLSHTMDPVNNIDLTHDHSREVSSKEDINIEPV--NPDEDEREKTQDNTAAVKTEGIRNSE 181

  Fly    67 TVAIAKD-------MLQLHHGAAAAATAAL----NNYNNSSNNNNNSADQLTGNSNNSANHPPAT 120
            ..:|.||       ...:|..:....|..|    :..||..:..|||...:....:.....||..
Yeast   182 DTSIQKDEPTADAIYTDVHKLSVNKDTETLPTLVDEKNNMLHMRNNSITPIMFQQHELVGQPPQN 246

  Fly   121 SSTTNSSSSSTTSANTNNPSANAASTLTSSSP---PYGELRFNQEVLPITDAVTVIGRNSSTSLV 182
            :.|.|:|:.:.|:....:...:|:..|.:..|   .|..|.|......:.....:|||.|.....
Yeast   247 TVTENNSTDAETTQRKLSEPIDASLPLPNEQPTIFAYARLDFQSFTFYVQTLHAIIGRRSENDFS 311

  Fly   183 H---FNVAENNLVSRKHFQVLYDVELRAFFVQCLSKNGIFVDD-FLQRRNVDPLRLPQRCYFRFP 243
            |   .|:..:..:||:|.|:.|:.....|.:..:.|||.|||| |:::.|..|||         .
Yeast   312 HKVDVNLGPSKSISRRHAQIFYNFGTGRFELSIIGKNGAFVDDIFVEKGNTVPLR---------N 367

  Fly   244 STEIRIEFESYVPATSSDAIDGHSPSLVVGGGGGVAGGGAHVIITPLPRDELHQQQLHHHQQQPH 308
            .|:|:|               |..|...:                 ||..|
Yeast   368 KTKIQI---------------GQIPFQFI-----------------LPEQE-------------- 386

  Fly   309 LQQQQHPHHPPAHHLPLQQQQQQQQPAHHPLPHTPHHPLHHTALHQQQQRSGSIVVAPPAGAAAH 373
                              :....:.|.:..:..:   .::...|.:.:.:|...:.   .||.
Yeast   387 ------------------RNDDSKSPENADIAES---EINTRNLKKNEPKSKKKIT---TGAK-- 425

  Fly   374 LIAGDGPGIYSPLKISIPKKEQKSPYLSPTGTISAANSCPASPRQGF-IQNQPNNYNNYGNNNTQ 437
                             |||.|..|      .:......|..|::.: ::..|..|..
Yeast   426 -----------------PKKAQTKP------AVKKEKKPPKIPKKVYTLEEIPVEYRT------- 460

  Fly   438 DLFQTPSTASYNHNEKPPYSYAQLIVQAI---SAAPDKQLTLSGIYSFIVKHYPYYRKETNKGWQ 499
                           ||..||:.::...|   |.|  |.::||.||:.|.:.:||| |....|||
Yeast   461 ---------------KPTVSYSAMLTTCIRKYSTA--KGMSLSEIYAGIRELFPYY-KYCPDGWQ 507

  Fly   500 NSIRHNLSLNRYFIKVARSQDEPGKGSFWRIDPDSGAKLIDHSYKKRRQRSSQGFRPPYGMPRSA 564
            :|:|||||||:.|.||::.    |||..|.:|.       ::..::.||:..|. .......::|
Yeast   508 SSVRHNLSLNKSFRKVSKE----GKGWLWGLDE-------EYIAERERQKKKQS-EIAVAKAQAA 560

  Fly   565 PVSPSHMDNSRESSP---LQDIVLQ-SAPGSPGMSLEQRAADPEIIYNSQNAHQQQQQQQQQQQQ 625
            .:......:..:..|   .:|||.| |...:...::.|..|......|.:|.....|:..:..|:
Yeast   561 QLKLEQQQHKLQQVPQRGKKDIVSQRSNVNARKQNISQTLAANRAASNRKNTASDNQRTMKYLQE 625

  Fly   626 QTLSNNSNQYSSGSPYYVTNQSSGVATPQTHVEGSAASGGGGGGGVGALLALKRNH--------- 681
            |.:....::............:..:|.....|..:|.:.|..|..:.||:.....|
Yeast   626 QLVILTRDRKGLSKQVIAAILTQALAMTINQVTQAAKNKGITGNPLTALMDKNPQHLNLILAAAV 690

  Fly   682 ------VMGGGASQ----HTLHQQQAVAQQQHSEIIYEELPTDYSGHI 719
                  |..|...|    .|.......|:.|||:.|.:  |...:.|:
Yeast   691 NAATAKVTKGEVKQLVNPETTAAAALAAKAQHSKPIRQ--PIVQTPHV 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FoxK	NP_001261701.1	FHA	<170..253	CDD:238017	27/86 (31%)
FoxK	NP_001261701.1	Forkhead	453..540	CDD:278670	36/89 (40%)
FHL1	NP_015429.1	COG5025	18..739	CDD:227358	153/763 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I3087
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1668
TreeFam	0	0.000	Not matched by this tool.
	4	3.810