DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FoxK and FKH2

DIOPT Version :9

Sequence 1:	NP_001261701.1	Gene:	FoxK / 39252	FlyBaseID:	FBgn0036134	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_014331.3	Gene:	FKH2 / 855656	SGDID:	S000005012	Length:	862	Species:	Saccharomyces cerevisiae

Alignment Length:	642	Identity:	158/642 - (24%)
Similarity:	257/642 - (40%)	Gaps:	155/642 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 SNNNNNSADQLT------GNSNNSANHPPAT-----SSTTNSSSSSTTSANTNNPSANAASTLTS 149
            |::|.|..::|.      |::..:|.|....     ||.|.....:|.|...:| ..|.|:.:.:
Yeast     2 SSSNFNEMNELNMTQTNYGSTKYTAQHHQGVINAIISSLTAPDQPTTVSLQYSN-DKNMATEIQA 65

  Fly   150 SSPPYGELRFNQEVLPITDAVTVIGRNS---------------STSLVHFNVAENNLVSRKHFQV 199
                |.:|........:.|....||||:               ::..|:.::....:|||||..:
Yeast    66 ----YAKLSGPNWTYYVKDLEVSIGRNTDPLNSALQENSDGVKNSYRVNIDLGPAKVVSRKHAII 126

  Fly   200 LYDVELRAFFVQCLSKNGIFVDDFLQRR----NVDPLRLPQRCYFRFPSTEIRIEFESYVPATSS 260
            .|::.:..:.:..|.:||..|:  .||.    |..|:||..........|::........|..:.
Yeast   127 KYNMNIGGWELHILGRNGAKVN--FQRTHNGPNNPPIRLSSGTLLDIGGTQMMFILPDSDPVVAP 189

  Fly   261 DAIDGHSPSLVVGGGGGVAGGGAHVIITPLPRDELHQQQLHHHQQQPHLQQQQHPHHPPAHHLPL 325
            ..|:...|:|:  ...|:.|..     .||.||.:        :|..:.:|:|
Yeast   190 ICIEHLMPNLI--NMFGLEGNN-----NPLLRDII--------KQSNYAKQRQ------------ 227

  Fly   326 QQQQQQQQPAHHPLPHTPHHPLHHTALHQQQQRSGSIVVA----PPAGAAAHLIAGDGP---GIY 383
                                      |...||..|..:..    .|.|:.|:|    ||   ||:
Yeast   228 --------------------------LTSNQQIKGFKLYGSGGNAPFGSGANL----GPSEQGIF 262

  Fly   384 SPLKISIPKKEQKSPY---LSPTGTISAANSCPASPRQGFIQNQPN-----NY-NNYGNNNT--Q 437
            :    :....:.|:.|   ::|..|.|...|...:|:....|..||     |: ::|.::|.  |
Yeast   263 N----NNNNSKNKNGYFTSINPNYTASTTTSNTINPQAASPQGPPNTIIAANFVDSYKSSNAYPQ 323

  Fly   438 DL-FQTPSTASYNHNEKPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKETNKGWQNS 501
            .| |.:..:...|.|.|||:|||.:|.|||.::|:..::|:.||.:|..:|.||| ....|||||
Yeast   324 ALDFTSDLSHDENRNVKPPHSYATMITQAILSSPEGVISLADIYKYISSNYAYYR-FAKSGWQNS 387

  Fly   502 IRHNLSLNRYFIKVARSQDEPGKGSFWRIDPDSGAKLIDH----SYKKRRQRSSQGFRPPYGMPR 562
            ||||||||:.|.||.|..:|||||..|||......:.::.    ...|.|:.||...:....|.:
Yeast   388 IRHNLSLNKAFEKVPRRPNEPGKGMKWRISESYQQEFLNKWNTGKVGKIRRGSSVARQLQLHMAK 452

  Fly   563 --SAPVSPSHMDNSRESSP----LQ----------DIV---LQSAPGSPGMSLEQRAADPEIIYN 608
              |.|:...:..:...:.|    ||          :|:   :|..|....:...|::..|   .:
Yeast   453 FNSLPMEMDYRLSLNMAQPPKRQLQSHNVLEPSNNNIIEGFVQHVPSKGNLPASQQSQPP---VS 514

  Fly   609 SQNAHQQQQQQQQQQQ-QQTLSNNSNQ-YSSGSPYYVTNQSSGVATPQTHVEGSAAS 663
            .||..||...|:|:|: |.|.::..|: .:...|         :.|||.....|.|:
Yeast   515 HQNQSQQPPPQEQRQEIQFTFADTQNRNIALARP---------IKTPQLQAPNSNAN 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FoxK	NP_001261701.1	FHA	<170..253	CDD:238017	22/101 (22%)
FoxK	NP_001261701.1	Forkhead	453..540	CDD:278670	44/86 (51%)
FKH2	NP_014331.3	COG5025	1..610	CDD:227358	158/642 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	97	1.000	Domainoid score	I1615
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	105	1.000	Inparanoid score	I1420
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	1	1.000	-	-		otm46522
orthoMCL	1	0.900	-	-		OOG6_104629
Panther	1	1.100	-	-	LDO	PTHR45881
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2114
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.890