DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FoxK and foxj3

DIOPT Version :9

Sequence 1:	NP_001261701.1	Gene:	FoxK / 39252	FlyBaseID:	FBgn0036134	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_001313317.1	Gene:	foxj3 / 797147	ZFINID:	ZDB-GENE-101005-1	Length:	596	Species:	Danio rerio

Alignment Length:	455	Identity:	115/455 - (25%)
Similarity:	174/455 - (38%)	Gaps:	155/455 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   398 PYLSPTGTISAANS----CPASPRQGFIQNQPNNYNNYGNNNTQDLFQTPSTASYNHNEKPPYSY 458
            |.|:....|..|::    .|..|::..:.:.         |.|.|    ......:.:.||||||
Zfish    16 PQLTMRAAIQKADAQNAHGPGMPKKSALLDP---------NTTLD----QEEVQQHKDGKPPYSY 67

  Fly   459 AQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKETNKGWQNSIRHNLSLNRYFIKVARSQDEPG 523
            |.||..||:::|.|::|||.||.:|..::|||| |...||:||||||||||:.|:||.||:|:||
Zfish    68 ASLITFAINSSPKKKMTLSEIYQWICDNFPYYR-EAGSGWKNSIRHNLSLNKCFLKVPRSKDDPG 131

  Fly   524 KGSFWRIDPDSGAKLIDHSYKKRRQRSSQGFRPPYGMPR---------SAPVSP----------- 568
            |||:|.||.:.....:. :..|:|.||.:....||.:..         |...||
Zfish   132 KGSYWAIDTNPKEDTLP-TRPKKRPRSGERASTPYSLESDNLGMDCIISGSASPTLAINTVTNKV 195

  Fly   569 --------------SHMDNSRESSPLQDIVLQSAPG--------------SPGMSLEQRA----- 600
                          |.::||.....|..:.|.|...              |..|||:|..
Zfish   196 ALYNPDQDGSDSPRSSLNNSLSDQSLASVNLNSVGSVHSYTPVTSHPESVSQSMSLQQAPQAQYS 260

  Fly   601 ---ADPEIIYNS------------QNAHQQQQQQQ------QQQQQQTLS-------------NN 631
               .|.:::::.            :...:|...||      .:..|||.:             ||
Zfish   261 IPDRDKQLLFSEFEDLSASFRSLYKTVFEQSYNQQSLMGLPSESSQQTHTSCSYQHSPSSHPHNN 325

  Fly   632 SNQYSSGSPYYVTNQSSGVATPQTHVEGSAASGGGGGGGVGALLALKRNHVMGGGA--------- 687
            .|..::..|..:.|..|.|  |.:|...||.:...|            .|:...|.
Zfish   326 QNSITNSHPNNIPNNGSQV--PLSHPPHSAHNSPHG------------QHLSQHGPHSQHPHTAH 376

  Fly   688 ------------SQHTLHQQQA-------VAQQQHSEIIYEE-------LPTDYSGHIEASEEEC 726
                        |||:.|..||       ..||||..:.:::       |.:|:..:::|.:|.|
Zfish   377 SQHPQHSQHPQHSQHSQHGHQAHGQHTAQQQQQQHQNLSHQQQMQCNTGLLSDWYPNLDALKESC 441

Fly 727 726
Zfish 442 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FoxK	NP_001261701.1	FHA	<170..253	CDD:238017
FoxK	NP_001261701.1	Forkhead	453..540	CDD:278670	50/86 (58%)
foxj3	NP_001313317.1	Forkhead	62..139	CDD:278670	48/77 (62%)
foxj3	NP_001313317.1	SelP_N	<327..394	CDD:282453	15/80 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820